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18 条记录 (耗时 0.026 秒)

    6-11 Bicyclic ketolide derivatives
    1.
    发明申请
    6-11 Bicyclic ketolide derivatives 有权
    6-11双环酮内酯衍生物

    公开(公告)号：US20050282758A1

    公开(公告)日：2005-12-22

    申请号：US11154260

    申请日：2005-06-16

    申请人： Deqiang Niu ,  Guoqiang Wang ,  Yat Or ,  Ly Phan

    发明人： Deqiang Niu ,  Guoqiang Wang ,  Yat Or ,  Ly Phan

    IPC分类号： A61K31/7052 ,  A61K45/06 ,  C07H17/08

    CPC分类号： C07H17/08 ,  A61K31/7052 ,  A61K45/06 ,  Y02A50/401 ,  Y02A50/478 ,  A61K2300/00

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    6-11 Bicyclic erythromycin derivatives
    2.
    发明申请
    6-11 Bicyclic erythromycin derivatives 失效
    6-11双环红霉素衍生物

    公开(公告)号：US20050187169A1

    公开(公告)日：2005-08-25

    申请号：US11029640

    申请日：2005-01-05

    申请人： Nha Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Phan ,  Zhe Wang ,  Yat Or

    发明人： Nha Vo ,  Guoqiang Wang ,  Guoyou Xu ,  Ying Hou ,  Ying Sun ,  Ly Phan ,  Zhe Wang ,  Yat Or

    IPC分类号： A61K31/70 ,  A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulaes I, II, III, or IV, or a racemate, enantiomer, regioisomer, salt, ester or prodrug thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I，II，III或IV的化合物或其外消旋体，对映异构体，区域异构体，盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9A,11-2C-bicyclic 9a-azalide derivatives
    4.
    发明申请
    9A,11-2C-bicyclic 9a-azalide derivatives 有权
    9A，11-2C-双环9a-氮杂环戊二烯衍生物

    公开(公告)号：US20060154881A1

    公开(公告)日：2006-07-13

    申请号：US11324502

    申请日：2006-01-03

    申请人： Yat Or ,  Ly Phan ,  Guoqiang Wang ,  Yanchun Wang ,  Yulin Peng

    发明人： Yat Or ,  Ly Phan ,  Guoqiang Wang ,  Yanchun Wang ,  Yulin Peng

    IPC分类号： A61K31/7052 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    9a,11-3C-bicyclic 9a-azalide derivatives
    6.
    发明申请
    9a,11-3C-bicyclic 9a-azalide derivatives 有权
    9a，11-3C-双环9a-氮杂衍生物

    公开(公告)号：US20050090460A1

    公开(公告)日：2005-04-28

    申请号：US10946339

    申请日：2004-09-21

    申请人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Phan ,  Yat Or

    发明人： Guoqiang Wang ,  Yulin Peng ,  Yanchun Wang ,  Ly Phan ,  Yat Or

    IPC分类号： A61K31/7052 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    3,6-BRIDGED TYLOSIN DERIVATIVES
    7.
    发明申请
    3,6-BRIDGED TYLOSIN DERIVATIVES 审中-公开
    3,6-桥状酪氨酸衍生物

    公开(公告)号：US20080039406A1

    公开(公告)日：2008-02-14

    申请号：US11828473

    申请日：2007-07-26

    申请人： Yao-Ling Qiu ,  Tongzhu Liu ,  Yat Or ,  Ly Phan

    发明人： Yao-Ling Qiu ,  Tongzhu Liu ,  Yat Or ,  Ly Phan

    IPC分类号： A61K31/7048 ,  A61P25/00 ,  A61P31/04 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formula I, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其表现出抗菌性质。 本发明还涉及包含上述化合物的药物组合物，用于给予需要抗生素治疗的受试者。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的细菌感染的方法。 本发明还包括制备本发明化合物的方法。

    Novel bicyclic 9a-azalide derivatives
    8.
    发明申请
    Novel bicyclic 9a-azalide derivatives 失效
    新型双环9a-氮杂衍生物

    公开(公告)号：US20060069048A1

    公开(公告)日：2006-03-30

    申请号：US11236043

    申请日：2005-09-27

    申请人： Yat Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

    发明人： Yat Or ,  Yao-Ling Qiu ,  Guoqiang Wang ,  Deqiang Niu ,  Ly Phan

    IPC分类号： C07H17/08 ,  A61K31/7052

    CPC分类号： C07H17/08

    摘要： The present invention discloses compounds of formulae I and II, or pharmaceutically acceptable salts, esters, or prodrugs thereof: which exhibit antibacterial properties. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject in need of antibiotic treatment. The invention also relates to methods of treating a bacterial infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The invention further includes process by which to make the compounds of the present invention.

    摘要翻译： 本发明公开了式I和II的化合物或其药学上可接受的盐，酯或前药：

    Antibacterial compounds with improved pharmacokinetic profiles
    10.
    发明申请
    Antibacterial compounds with improved pharmacokinetic profiles 审中-公开
    具有改善药代动力学特征的抗菌化合物

    公开(公告)号：US20050267054A1

    公开(公告)日：2005-12-01

    申请号：US11167493

    申请日：2005-06-27

    申请人： Richard Clark ,  Stevan Djuric ,  Zhenkun Ma ,  Ly Phan ,  Michael Rupp

    发明人： Richard Clark ,  Stevan Djuric ,  Zhenkun Ma ,  Ly Phan ,  Michael Rupp

    IPC分类号： A61K31/7048 ,  C07H17/08

    CPC分类号： C07H17/08

    摘要： Antibacterial compounds with improved pharmacokinetic profiles having formula (I) and salts, prodrugs, and salts of prodrugs thereof, processes for making the compounds and intermediates used in the processes, compositions containing the compounds, and methods for prophylaxis and treatment of bacterial infections using the compounds are disclosed.

    摘要翻译： 具有式（I）的具有改善的具有式（I）的药代动力学特征的抗菌化合物及其前体药物的盐，前药和盐，用于制备该方法中使用的化合物和中间体的方法，含有该化合物的组合物，以及使用该方法预防和治疗细菌感染的方法 公开了化合物。