公开(公告)号：US09078851B2

公开(公告)日：2015-07-14

申请号：US13390892

申请日：2010-08-17

申请人： Young Sook Son ,  Mei Hua Jiang

发明人： Young Sook Son ,  Mei Hua Jiang

IPC分类号： A01N37/18 ,  A61K38/00 ,  A61K38/10

CPC分类号： A61K38/10

摘要： The present invention relates to a novel use of substance P. The substance P of the present invention exhibits effects of decreasing microglia activity, decreasing proinflammatory cytokines, inhibiting apoptosis, etc. The substance P of the present invention effectively treats degenerative central nervous system diseases or disorders such as a spinal cord injury caused by a traumatic injury (flexion injury, vertical compression injury, hyperextension injury, flexion-rotation injury) and by a non-traumatic injury (vascular dysfunction, arthritis, or degenerative arthritis), Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, depressive disorder, epilepsy, etc.

摘要翻译： 本发明涉及物质P的新用途。本发明的物质P具有降低小胶质细胞活性，降低促炎细胞因子，抑制凋亡等作用。本发明的物质P有效治疗退行性中枢神经系统疾病或 由创伤性损伤（屈曲损伤，垂直压迫性损伤，过度伸张损伤，屈曲旋转损伤）和非创伤性损伤（血管功能障碍，关节炎或退行性关节炎）引起的脊髓损伤，帕金森氏病，阿尔茨海默病 疾病，肌萎缩性侧索硬化，亨廷顿病，抑郁障碍，癫痫等。

公开(公告)号：US20120225821A1

公开(公告)日：2012-09-06

申请号：US13390892

申请日：2010-08-17

申请人： Young Sook Son ,  Mei Hua Jiang

发明人： Young Sook Son ,  Mei Hua Jiang

IPC分类号： A61K38/08 ,  A61P25/28 ,  C07K7/06 ,  A61P25/14 ,  A61P25/24 ,  A61P25/08 ,  A61P25/16 ,  A61P25/00

CPC分类号： A61K38/10

摘要： The present invention relates to a novel use of substance P. The substance P of the present invention exhibits effects of decreasing microglia activity, decreasing proinflammatory cytokines, inhibiting apoptosis, etc. The substance P of the present invention effectively treats degenerative central nervous system diseases or disorders such as a spinal cord injury caused by a traumatic injury (flexion injury, vertical compression injury, hyperextension injury, flexion-rotation injury) and by a non-traumatic injury (vascular dysfunction, arthritis, or degenerative arthritis), Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, Huntington's disease, depressive disorder, epilepsy, etc.

摘要翻译： 本发明涉及物质P的新用途。本发明的物质P具有降低小胶质细胞活性，降低促炎细胞因子，抑制凋亡等作用。本发明的物质P有效治疗退行性中枢神经系统疾病或 由创伤性损伤（屈曲损伤，垂直压迫性损伤，过度伸张损伤，屈曲旋转损伤）和非创伤性损伤（血管功能障碍，关节炎或退行性关节炎）引起的脊髓损伤，帕金森氏病，阿尔茨海默病 疾病，肌萎缩性侧索硬化，亨廷顿病，抑郁障碍，癫痫等。

公开(公告)号：US20130078291A1

公开(公告)日：2013-03-28

申请号：US13702852

申请日：2011-11-10

申请人： Young Sook Son ,  Eun Ah Lee ,  Seung Woo Nam

发明人： Young Sook Son ,  Eun Ah Lee ,  Seung Woo Nam

IPC分类号： A61L24/00

CPC分类号： A61L24/00 ,  A61L24/02 ,  A61L27/32 ,  A61L2400/18

摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.

摘要翻译： 本发明涉及包含表面改性羟基磷灰石的生物粘合剂及其用途。 更具体地，本发明涉及用于骨与骨，骨和组织，骨和软骨或骨和腱之间的粘附的生物粘合剂，或用于在骨骼或人造关节之间粘合屏蔽物 包括表面改性的羟基磷灰石作为活性成分，其中表面改性的羟基磷灰石的特征在于某些连接体化合物与羟基磷灰石的表面共价键合; 使用表面改性羟基磷灰石涂覆金属假体的表面的方法; 以及通过所述方法获得的涂覆有表面改性羟基磷灰石的金属假体。

公开(公告)号：US09107976B2

公开(公告)日：2015-08-18

申请号：US13702852

申请日：2011-11-10

申请人： Young Sook Son ,  Eun Ah Lee ,  Seung Woo Nam

发明人： Young Sook Son ,  Eun Ah Lee ,  Seung Woo Nam

IPC分类号： A61L24/00 ,  A61L24/02 ,  A61L27/32

CPC分类号： A61L24/00 ,  A61L24/02 ,  A61L27/32 ,  A61L2400/18

摘要： The present invention relates to a bio-adhesive agent comprising a surface-modified hydroxyapatite and its use. More specifically, the present invention relates to a bio-adhesive agent for the adhesion between bone and bone, bone and tissue, bone and cartilage, or bone and tendon, or for the adhesion of a shield between bones or of an artificial joint, which comprises a surface-modified hydroxyapatite as an active ingredient, wherein the surface-modified hydroxyapatite is characterized in that a certain linker compound is covalently bonded to the surface of the hydroxyapatite; a method for coating the surface of a metal prosthesis using the surface-modified hydroxyapatite; and a metal prosthesis coated with the surface-modified hydroxyapatite obtained by said method.

摘要翻译： 本发明涉及一种包含表面改性羟基磷灰石的生物粘合剂及其用途。 更具体地，本发明涉及用于骨与骨，骨和组织，骨和软骨或骨和腱之间的粘附的生物粘合剂，或用于在骨骼或人造关节之间粘合屏蔽物 包括表面改性的羟基磷灰石作为活性成分，其中表面改性的羟基磷灰石的特征在于某些接头化合物共价键合到羟基磷灰石的表面上; 使用表面改性羟基磷灰石涂覆金属假体的表面的方法; 以及通过所述方法获得的涂覆有表面改性羟基磷灰石的金属假体。