公开(公告)号：US20230100089A1

公开(公告)日：2023-03-30

申请号：US17731348

申请日：2022-04-28

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Duncan Mwangi ,  Joseph M. Bricker ,  Dennis L. Foss ,  Sharath K. Rai ,  Suman Mahan

IPC分类号： A61K39/39 ,  A61K31/704 ,  A61K45/06 ,  A61K31/14 ,  A61K31/575 ,  A61K31/7028

摘要： The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.

公开(公告)号：US20180021424A1

公开(公告)日：2018-01-25

申请号：US15213627

申请日：2016-07-19

申请人： Zoetis Services LLC

发明人： Paul Joseph Dominowski ,  Duncan Mwangi ,  Sharath K. Rai ,  Dennis L. Foss ,  Traci K. Godbee ,  Laurel Mary Sly ,  Suman Mahan ,  Shaunak Vora

IPC分类号： A61K39/12 ,  A61K39/39 ,  A61K39/145 ,  C12N7/00 ,  A61K39/002 ,  C12N15/117 ,  A61K39/265

CPC分类号： A61K39/12 ,  A61K39/012 ,  A61K39/39 ,  A61K2039/5252 ,  A61K2039/552 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/70 ,  C12N7/00 ,  C12N2710/16734 ,  C12N2710/16771 ,  C12N2760/16134 ,  C12N2760/16171 ,  C12N2770/24034 ,  C12N2770/24334 ,  C12N2770/24371

摘要： The invention provides a liposomal adjuvant composition comprising an external membrane and an internal compartment, the external membrane comprising: a quaternary ammonium compound; a sterol; a phospholipid; and a glycolipid. Vaccine compositions comprising the liposomal adjuvant of the instant invention are also provided.

公开(公告)号：US20180008701A1

公开(公告)日：2018-01-11

申请号：US15039733

申请日：2014-11-21

申请人： ZOETIS SERVICES LLC

发明人： Paul Joseph Dominowski ,  Duncan Mwangi ,  Joseph Bricker ,  Dennis Foss ,  Sharath K. Rai ,  Suman Mahan

IPC分类号： A61K39/39 ,  A61K39/00

CPC分类号： A61K39/39 ,  A61K31/14 ,  A61K31/575 ,  A61K31/7028 ,  A61K31/704 ,  A61K45/06 ,  A61K2039/545 ,  A61K2039/55511 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2300/00

摘要： The invention provides a substantially antigen-free composition for induction of innate immune response in a bird or a mammal, the composition comprising a saponin, a sterol, a quaternary amine, and a polyacrylic polymer to the mammal or bird. Methods of using the composition are also provided.