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11.发明授权公开(公告)号：US07468254B2
公开(公告)日：2008-12-23
申请号：US10949846
申请日：2004-09-24
IPC分类号： G01N33/53 , G01N33/574 , C07K16/00
CPC分类号： G01N33/57492 , A61K47/6851 , A61K51/1045 , A61K51/1051 , A61K51/1096 , A61K2039/505 , C07K14/4748 , C07K16/00 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/3046 , C07K16/3053 , C07K16/3069 , C07K2317/34 , C12N9/1051 , G01N33/56966 , G01N33/5743 , G01N33/57484
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMABs of the instant invention.
摘要翻译： 本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用任选与一种或多种化学治疗剂组合的癌性疾病修饰抗体（CDMAB）作为起始细胞毒性应答的手段。 本发明还涉及利用本发明的CDMABs的结合测定法。
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公开(公告)号：US07456258B2
公开(公告)日：2008-11-25
申请号：US11496392
申请日：2006-07-31
IPC分类号： C07K16/00 , C12P21/08 , A61K39/00 , G01N33/53 , A61K39/395
CPC分类号： G01N33/57492 , A61K2039/505 , C07K16/30 , C07K16/3069 , C07K2317/73
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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公开(公告)号：US20080213267A1
公开(公告)日：2008-09-04
申请号：US11975896
申请日：2007-10-22
IPC分类号： A61K39/395 , G01N33/53 , C07K16/00
CPC分类号： G01N33/574 , A61K31/7068 , A61K39/39558 , A61K2039/505 , A61K2039/545 , C07K16/30 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/734 , C07K2317/92 , A61K2300/00
摘要： This invention relates to the staging, diagnosis and treatment of cancerous diseases (both primary tumors and tumor metastases), particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB), optionally in combination with one or more CDMAB/chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays, which utilize the CDMAB of the instant invention. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
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公开(公告)号：US07399835B2
公开(公告)日：2008-07-15
申请号：US11067366
申请日：2005-02-25
IPC分类号： C07K16/00 , C12P21/08 , A61K39/00 , G01N33/53 , A61K39/395
CPC分类号： C07K16/3069 , A61K2039/505 , C07K16/30 , C07K16/3046
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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公开(公告)号：US07348413B2
公开(公告)日：2008-03-25
申请号：US11067390
申请日：2005-02-25
IPC分类号： C07K16/00 , C12P21/08 , A61K39/00 , G01N33/53 , A61K39/395
CPC分类号： C07K16/30 , A61K2039/505
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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公开(公告)号：US20070202113A1
公开(公告)日：2007-08-30
申请号：US11709676
申请日：2007-02-22
申请人： David Young , Helen Findlay , Susan Hahn , Luis DaCruz , Alison Ferry
发明人： David Young , Helen Findlay , Susan Hahn , Luis DaCruz , Alison Ferry
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06 , C07K16/30
CPC分类号： C07K16/30 , A61K47/6851 , A61K51/1045 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , G01N33/57484
摘要： The present invention relates to a method for producing cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, cytokines, interferons, target or reporter moieties and hematogenous cells.
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公开(公告)号：US07195764B2
公开(公告)日：2007-03-27
申请号：US10944664
申请日：2004-09-15
IPC分类号： A61K39/395 , C12P21/04 , C12P21/08 , C07K16/00
CPC分类号： A61K51/1063 , A61K51/1051 , A61K51/1072 , A61K2039/505 , C07K16/00 , C07K16/30 , C07K16/3046
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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18.发明申请公开(公告)号：US20070053836A1
公开(公告)日：2007-03-08
申请号：US11592516
申请日：2006-11-03
申请人： David Young , Susan Hahn , Helen Findlay
发明人： David Young , Susan Hahn , Helen Findlay
IPC分类号： A61K51/00 , A61K39/395
CPC分类号： G01N33/566 , A61K39/39558 , A61K45/06 , A61K47/6849 , A61K49/0058 , A61K51/1027 , A61K2039/505 , B82Y5/00 , C07K16/00 , C07K16/2884 , C07K16/30 , C07K16/3015 , C07K2317/73 , G01N33/5011 , G01N33/5014 , G01N33/5082 , G01N33/56972 , G01N33/574 , G01N33/57415 , G01N33/57419 , G01N33/57423 , G01N33/57449 , G01N33/57484 , A61K2300/00
摘要： This invention relates to the diagnosis and treatment of cancerous diseases, particularly to the mediation of cytotoxicity of tumor cells; and most particularly to the use of cancerous disease modifying antibodies (CDMAB) or derivatives thereof, optionally in combination with one or more chemotherapeutic agents, as a means for initiating the cytotoxic response. The invention further relates to binding assays which utilize the CDMABs of the instant invention.
摘要翻译： 本发明涉及癌症的诊断和治疗，特别涉及肿瘤细胞的细胞毒性的介导; 并且最特别地涉及使用癌变疾病修饰抗体（CDMAB）或其衍生物，任选地与一种或多种化学治疗剂组合，作为起始细胞毒性应答的手段。 本发明还涉及利用本发明的CDMABs的结合测定法。
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公开(公告)号：US07175846B2
公开(公告)日：2007-02-13
申请号：US11462092
申请日：2006-08-03
IPC分类号： A61K39/395 , G01N33/574 , C12P21/04 , C12P21/08 , C07K16/00
CPC分类号： C07K16/3015 , A61K2039/505 , C07K16/2896 , C07K16/3069
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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公开(公告)号：US07009040B2
公开(公告)日：2006-03-07
申请号：US10348231
申请日：2003-01-21
IPC分类号： C07K16/00 , A61K39/395 , G01N33/53
CPC分类号： C07K16/3046 , A61K51/1045 , A61K51/1051 , A61K51/1096 , A61K2039/505 , C07K16/00 , C07K16/30 , C07K16/3015 , C07K16/3023 , C07K16/3069 , G01N33/574 , G01N33/57484
摘要： The present invention relates to a method for producing patient cancerous disease modifying antibodies using a novel paradigm of screening. By segregating the anti-cancer antibodies using cancer cell cytotoxicity as an end point, the process makes possible the production of anti-cancer antibodies for therapeutic and diagnostic purposes. The antibodies can be used in aid of staging and diagnosis of a cancer, and can be used to treat primary tumors and tumor metastases. The anti-cancer antibodies can be conjugated to toxins, enzymes, radioactive compounds, and hematogenous cells.
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