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公开(公告)号：US20210318397A1
公开(公告)日：2021-10-14
申请号：US17021773
申请日：2020-09-15
发明人： Peter G. Piferi
摘要： A cannula for transferring a substance to and/or from a patient includes a rigid, tubular support sleeve, an inner sleeve, a transfer tube, and a conformal polymeric sleeve. The support sleeve defines a support sleeve lumen extending from a first opening at a proximal end of the support sleeve to a second opening at a distal end of the support sleeve. The support sleeve includes a rigid, MRI-compatible material. The inner sleeve is disposed in the support sleeve lumen and extends beyond the distal end of the support sleeve to a distal end of the inner sleeve. The inner sleeve defines an inner sleeve lumen. The transfer tube is disposed in the inner sleeve lumen and extends to or beyond the distal end of the inner sleeve to a distal end of the transfer tube. The transfer tube defines a transfer tube lumen terminating at an opening at the distal end of the transfer tube. The conformal polymeric sleeve surrounds at least a portion of the support sleeve and at least a portion of the inner sleeve. The conformal polymeric sleeve includes a transitional section extending from the distal end of the support sleeve and over the inner sleeve in a direction toward the distal end of the inner sleeve. The transitional section tapers inwardly in the direction toward the distal end of the inner sleeve.
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12.发明申请公开(公告)号：US20210282866A1
公开(公告)日：2021-09-16
申请号：US17185060
申请日：2021-02-25
发明人： Kamal Vij , Peter G. Piferi , Maxwell Jerad Daly
摘要： Surgical systems and methods for an MRI suite include a housing residing in an MRI scanner room of the MRI suite. The housing comprises a plurality of motors coupled to at least one motor driver (in the same or a different housing); and a plurality of elongate cables, one coupled to one of the plurality of motors residing in the same housing or a different housing. The elongate cables comprise MRI compatible material and having a length in a range of about 24 inches and 60 inches. One of the cables couples to one of the motors at a first end portion and a corresponding one actuator of the actuators of a trajectory guide at a second end portion.
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公开(公告)号：US20240261537A1
公开(公告)日：2024-08-08
申请号：US18430073
申请日：2024-02-01
发明人： Nathan Williams , Ernesto Salegio
CPC分类号： A61M25/0023 , A61M25/0662 , A61M2025/0024 , A61M2025/0681
摘要： A cannula and catheter system includes a cannula or catheter formed of an elongated body having a central lumen. The catheter has an outer sheath of rigid material. An inner tube is co-axially positioned within the outer sheath wherein the inner tube is made of a material that is less stiff than the outer sheath or wherein the outer sheath is more stiff or rigid than one or more sheaths, tubes or cannulas slidably nested within the outer sheath.
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14.发明公开公开(公告)号：US20240065662A1
公开(公告)日：2024-02-29
申请号：US17894589
申请日：2022-08-24
发明人： Lyubomir Zagorchev , Damon Hyde , Chen Li
CPC分类号： A61B6/541 , A61B34/20 , A61B2034/2051
摘要： Systems and methods provide automated systems for accurately estimating infusion coverage within a target brain region in real-time (or approximately real-time) during surgical procedures. Such accurate and real-time infusion coverage estimation enables intraoperative monitoring and adjustment of infusion parameters (e.g., cannula tip location, infusate delivery flow rate, etc.) for achieving optimal/improved infusion coverage for a given drug therapy. Accordingly, examples of the presently disclosed technology can improve the efficacy and safety of drug therapies delivered to the brain.
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15.发明公开公开(公告)号：US20230310799A1
公开(公告)日：2023-10-05
申请号：US18175638
申请日：2023-02-28
发明人： Peter G. Piferi
IPC分类号： A61M25/00
CPC分类号： A61M25/0068 , A61M25/0054 , A61M25/0023
摘要： Surgical catheters with sufficient flexibility to deflect in response to brain shift in vivo while remaining in a target trajectory to a target in the brain have an elongate body and an exposed internal distal tip. The elongate bodies can be 0.5-10 feet long and the exposed distal tip can be provided as a tip end of a fused silica transfer tube that extends through the elongate body. The surgical catheters can be affixed to a skull using a bolt with a through channel and a bolt nut with a through channel. A distal end of the surgical catheters can extend through a guide sheath coupled to the bolt to reach the target.
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公开(公告)号：US20230302255A1
公开(公告)日：2023-09-28
申请号：US18175635
申请日：2023-02-28
发明人： Peter G. Piferi
IPC分类号： A61M25/01
CPC分类号： A61M25/01 , A61M2025/0681
摘要： Systems for treatment include a sheath assembly with a guide sheath and a shoulder, a stylet releasably couplable to the guide sheath and extending a distance out of a distal end thereof for rigidity to facilitate proper positioning, a bolt configured to hold a seal member, a bolt nut coupleable to the bolt member to clamp the sheath assembly and the seal member in the bolt. A therapy device such as a flexible catheter is releasably interchangeably held in the guide sheath in lieu of the stylet. A portion of the flexible catheter can remain in the guide sheath in a brain of a patient with the guide sheath held by the bolt and bolt nut with another external portion residing outside these devices to allow the portion of the flexible catheter to move with the brain of the patient during treatment.
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17.发明授权公开(公告)号：US11707569B2
公开(公告)日：2023-07-25
申请号：US17032140
申请日：2020-09-25
CPC分类号： A61M5/1452 , A61K35/28 , A61M5/31513 , A61M5/31528 , A61M25/0102 , A61M39/10 , A61M2005/1403 , A61M2025/0166 , A61M2202/09 , A61M2205/0266 , A61M2210/0693
摘要： Devices for transferring fluid to or from a subject include a plunger assembly coupled to or coupleable to a cannula assembly to allow target fluid to be “front-loaded” into a distal end of the cannula assembly while the stylet is withdrawn a distance to create a vacuum and define a flow channel.
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18.发明申请公开(公告)号：US20230000561A1
公开(公告)日：2023-01-05
申请号：US17725077
申请日：2022-04-20
摘要： Methods and systems that provide quantitative assessments of in vivo thermal treatments, such as ablations, during image-guided surgeries using a high-resolution pre-operative MRI image segmented with a shape constrained and deformable mesh representations of brain structures and generating 3-D visualizations of thermally treated volumes during the thermal treatment that can provide near real time visual and quantitative feedback to a clinician.
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公开(公告)号：US20210100977A1
公开(公告)日：2021-04-08
申请号：US16887161
申请日：2020-05-29
发明人： Peter G. Piferi
摘要： Devices for transferring fluid to or from a subject include an extension tube assembly with an axially extending inner tube configured to couple to an elongate tubular cannula having opposing proximal and distal ends with an axially extending lumen and an axially extending inner tube. The inner tube extending through the tubular cannula defines an exposed needle tip and is in fluid communication with the inner tube of the extension tube assembly. The needle tip extends out of a distal end of the tubular cannula a suitable distance.
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公开(公告)号：US10905497B2
公开(公告)日：2021-02-02
申请号：US15934165
申请日：2018-03-23
摘要： A trajectory frame/guide assembly for use with surgical navigation systems includes a base having a patient access aperture formed therein. A yoke is mounted to the base and is rotatable about a roll axis. A platform is mounted to the yoke and is rotatable about a pitch axis and interchangeably holds a single lumen or multi-lumen guide array and a device guide. No x-y actuators are required and a virtual guide array may also or alternatively be used to identify a desired open channel in the device guide for the preferred trajectory path.
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