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    Use of circulating tumor cell mitotic index in cancer stratification and diagnostics
    13.
    发明授权
    Use of circulating tumor cell mitotic index in cancer stratification and diagnostics 有权

    公开(公告)号：US11150245B2

    公开(公告)日：2021-10-19

    申请号：US15576472

    申请日：2016-05-26

    Applicant: CREATV MICROTECH INC.

    Inventor： Daniel Adams ,  Cha-Mei Tang

    IPC: G01N33/574 ,  G01N33/50

    Abstract: Circulating tumor cells (CTCs) are associated with metastasis of malignant solid tumors in a patient. Presented here is evidence that CTCs exhibit cell cycle phase variability and that there is a strong correlation between the number of CTCs in a mitotic cell cycle phase and the prospects for long term survival of the subject from which the cells were obtained. Also presented herein are methods of determining the mitotic cell cycle phase of CTCs from a patient having cancer and using the information in grading malignant solid tumors and predicting the likelihood of survival of the patient.

    Anti-scatter grid and collimator designs, and their motion, fabrication and assembly
    14.
    发明授权
    Anti-scatter grid and collimator designs, and their motion, fabrication and assembly 有权
    防散射网格和准直器设计，以及它们的运动，制造和组装

    公开(公告)号：US07922923B2

    公开(公告)日：2011-04-12

    申请号：US11984634

    申请日：2007-11-20

    Applicant: Cha-Mei Tang ,  Olga V. Makarova ,  Platte T. Amstutz, III ,  Guohua Yang

    Inventor： Cha-Mei Tang ,  Olga V. Makarova ,  Platte T. Amstutz, III ,  Guohua Yang

    IPC: B44C1/22 ,  C03C15/00 ,  C03C25/68

    CPC classification number: G21K1/025

    Abstract: Grids and collimators, for use with electromagnetic energy emitting devices, include at least a metal layer that is formed, for example, by electroplating/electroforming or casting. The metal layer includes top and bottom surfaces, and a plurality of solid integrated walls. Each of the solid integrated walls extends from the top to bottom surface and has a plurality of side surfaces. The side surfaces of the solid integrated walls are arranged to define a plurality of openings extending entirely through the layer. At least some of the walls also can include projections extending into the respective openings formed by the walls. The projections can be of various shapes and sizes, and are arranged so that a total amount of wall material intersected by a line propagating in a direction along an edge of the grid is substantially the same as another total amount of wall material intersected by another line propagating in another direction substantially parallel to the edge of the grid at any distance from the edge. Methods to fabricate these grids using copper, lead, nickel, gold, any other electroplating/electroforming materials, metal composites or low melting temperature metals are described.

    Abstract translation: 用于电磁能发射装置的网格和准直器至少包括通过例如电镀/电铸或铸造形成的金属层。 金属层包括顶表面和底表面，以及多个固体整​​体壁。 每个固体一体化壁从顶部到底部表面延伸并且具有多个侧表面。 固体一体化壁的侧表面布置成限定完全延伸穿过该层的多个开口。 至少一些壁还可以包括延伸到由壁形成的相应开口中的突起。 突起可以是各种形状和尺寸，并且被布置成使得沿着沿着栅格的边缘的方向传播的线相交的壁材的总量基本上与另一个与另一条线相交的壁材料的总量相同 在距离边缘任何距离处基本上平行于栅格的边缘的另一方向上传播。 描述了使用铜，铅，镍，金，任何其它电镀/电铸材料，金属复合材料或低熔点金属制造这些栅极的方法。

    Sensitive emission light gathering and detection system
    15.
    发明授权
    Sensitive emission light gathering and detection system 有权
    敏感发射光采集和检测系统

    公开(公告)号：US07801394B2

    公开(公告)日：2010-09-21

    申请号：US11541785

    申请日：2006-10-03

    Applicant: Cha-Mei Tang ,  Platte T. Amstutz, III

    Inventor： Cha-Mei Tang ,  Platte T. Amstutz, III

    IPC: G02B6/32 ,  G02B6/42 ,  G02B6/00

    CPC classification number: G01N21/0303 ,  G01N21/255 ,  G01N21/645

    Abstract: A luminometer is provided comprising a waveguide sample holder and one or more detectors. The waveguide sample holder may include a hollow region to hold the sample. The waveguide sample holder can be made of material that guides emission light to a bottom end of the waveguide sample holder. One or more detectors may be provided which detect the emission light coming out of the bottom of the waveguide sample holder. A fluorometer/photometer is also provided that comprises a waveguide sample holder, one or more excitation light sources, and one or more optical detectors. The waveguide sample holder has a hollow region to hold the sample. The excitation light is introduced at an angle or perpendicular to one surface of the waveguide sample holder. The waveguide sample holder is made of material that can guide emission light to the bottom end of the waveguide sample holder. There are one or more detectors that detect the emission light coming out of the bottom of the waveguide sample holder.

    Abstract translation: 提供了一种发光计，其包括波导样本保持器和一个或多个检测器。 波导样品保持器可以包括用于保持样品的中空区域。 波导样品保持器可以由将发射光引导到波导样品保持器的底端的材料制成。 可以提供一个或多个检测器，其检测从波导样品保持器的底部出来的发射光。 还提供了一种荧光计/光度计，其包括波导样品保持器，一个或多个激发光源和一个或多个光学检测器。 波导样品保持器具有用于保持样品的中空区域。 激发光以与波导样品保持器的一个表面成一定角度或垂直的方向引入。 波导样品架由能够将发射光引导到波导样品架的底端的材料制成。 存在一个或多个检测器，其检测从波导样品保持器的底部出来的发射光。

    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES
    20.
    发明申请
    POLYMER MICROFILTRATION DEVICES, METHODS OF MANUFACTURING THE SAME AND THE USES OF THE MICROFILTRATION DEVICES 审中-公开
    聚合物微滤装置，其制造方法和微滤装置的用途

    公开(公告)号：US20140322743A1

    公开(公告)日：2014-10-30

    申请号：US14359467

    申请日：2012-11-21

    Applicant: Creatv Microtech, Inc.

    Inventor： Cha-Mei Tang ,  Yunqi Zhang

    IPC: G01N33/50 ,  B01D39/16 ,  B01L3/00 ,  B01L9/00

    CPC classification number: G01N33/5005 ,  B01D29/00 ,  B01D39/16 ,  B01D39/1692 ,  B01L3/50 ,  B01L3/502 ,  B01L3/5635 ,  B01L9/00 ,  B01L2300/0681 ,  G01N1/4005 ,  G01N1/4077 ,  G01N2001/4088 ,  Y10T29/49826 ,  Y10T29/49963

    Abstract: A microfilter comprising a polymer layer formed from epoxy-based photo-definable dry film, and a plurality of apertures each extending through the polymer layer. A microfilter comprising two or more polymer layers formed from epoxy-based photo-definable dry film, and a plurality of apertures or open areas each extending through the polymer layer. A method of forming a microfilter is also disclosed. The method includes providing a first layer of epoxy-based photo-definable dry film disposed on a substrate, exposing the first layer to energy through a mask to form a pattern, defined by the mask, in the first layer of dry film, forming, from the exposed first layer of dry film, a polymer layer having a plurality of apertures extending therethrough, the plurality of apertures having a distribution defined by the pattern, and removing the polymer layer from the substrate. Unique filter holder designs and methods appropriate to hold microfilters to collect the rare cells and allow performing assays in the filter holder are provided. The invention also describes the use of the microfilter and filter holder to collect rare cells from body fluids and perform assays. Rare cells collected on the microfilter in accordance with embodiments of the present invention can be used for medical and biological research applications.

    Abstract translation: 一种包含由环氧基可光定影干膜形成的聚合物层的微过滤器，以及遍及聚合物层的多个孔。 一种包含由环氧基可光限制的干膜形成的两个或更多个聚合物层的微过滤器，以及各自延伸穿过聚合物层的多个孔或开口区域。 还公开了一种形成微过滤器的方法。 该方法包括提供设置在基底上的第一层环氧基光可定义干膜，将第一层暴露于能量通过掩模，以在第一层干膜中形成由掩模限定的图案， 从曝光的第一层干膜，具有延伸穿过其中的多个孔的聚合物层，所述多个孔具有由图案限定的分布，以及从基底去除聚合物层。 提供了独特的过滤器支架设计和适用于容纳微过滤器以收集稀有细胞并允许在过滤器保持器中进行测定的方法。 本发明还描述了微过滤器和过滤器保持器从体液中收集稀有细胞并进行测定的用途。 根据本发明的实施方案收集在微过滤器上的稀有细胞可用于医学和生物研究应用。

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