公开(公告)号：US11860157B2

公开(公告)日：2024-01-02

申请号：US17526513

申请日：2021-11-15

Applicant: Creatv MicroTech, Inc.

Inventor： Olga Makarova ,  Cha-Mei Tang ,  Peixuan Zhu ,  Shuhong Li ,  Daniel Adams ,  Platte T. Amstutz

IPC: G01N33/50 ,  G01N1/40 ,  B01L3/00 ,  B01D39/16 ,  B01D29/00 ,  B01L9/00 ,  B01D71/46

CPC classification number: G01N33/5005 ,  B01D29/00 ,  B01D39/16 ,  B01D39/1692 ,  B01D71/46 ,  B01L3/50 ,  B01L3/5635 ,  B01L9/00 ,  G01N1/4005 ,  G01N1/4077 ,  B01D2239/0421 ,  B01L3/502 ,  B01L2300/0681 ,  G01N2001/4088 ,  Y10T29/49826 ,  Y10T29/49963

Abstract: A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

公开(公告)号：US20220074922A1

公开(公告)日：2022-03-10

申请号：US17526513

申请日：2021-11-15

Applicant: Creatv MicroTech, Inc.

Inventor： Olga Makarova ,  Cha-Mei Tang ,  Peixuan Zhu ,  Shuhong Li ,  Daniel Adams ,  Platte T. Amstutz

IPC: G01N33/50 ,  G01N1/40 ,  B01L3/00 ,  B01D39/16 ,  B01D29/00 ,  B01L9/00 ,  B01D71/46

Abstract: A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

公开(公告)号：US20190383794A1

公开(公告)日：2019-12-19

申请号：US16454937

申请日：2019-06-27

Applicant: Creatv MicroTech, Inc.

Inventor： Olga Makarova ,  Cha-Mei Tang ,  Peixuan Zhu ,  Shuhong Li ,  Daniel Adams ,  Platte T. Amstutz

IPC: G01N33/50 ,  G01N1/40 ,  B01L3/00 ,  B01D39/16 ,  B01D29/00 ,  B01L9/00

Abstract: A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

公开(公告)号：US10368541B2

公开(公告)日：2019-08-06

申请号：US14776194

申请日：2014-03-13

Applicant: Creatv MicroTech, Inc.

Inventor： Peixuan Zhu ,  Daniel Adams ,  Cha-Mei Tang

IPC: A01N1/02 ,  G01N33/493 ,  G01N33/574

Abstract: A preservative reagent for urine is disclosed that increases the stability of cells, such as tumor cells, in urine for a period of several weeks. The preservative reagent comprises polyethylene glycol (PEG), ethanol, paraformaldehyde (PFA), and ethylenediaminetetraacetic acid (EDTA), and optionally pH stabilizing reagents.

公开(公告)号：US20140315295A1

公开(公告)日：2014-10-23

申请号：US14213183

申请日：2014-03-14

Applicant: Creatv MicroTech, Inc.

Inventor： Olga Makarova ,  Cha-Mei Tang ,  Peixuan Zhu ,  Shuhong Li ,  Daniel Adams ,  Platte T. Amstutz

IPC: G01N1/34 ,  B01D39/16

CPC classification number: G01N1/34 ,  B01D39/1692 ,  B01D2239/0421 ,  G01N33/50

Abstract: A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

Abstract translation: 公开了一种具有亲水表面并且适合于基于尺寸的捕获和分析来自全血和其它人体液体的细胞例如循环癌细胞的微过滤器。 过滤材料是可光限定的，允许通过UV光刻形成精密孔。 示例性实施方案提供了一种将微型过滤器与模拟3D体内环境的3D纳米形成相结合的装置，以更好地促进捕获的细胞的生长。

公开(公告)号：US11175279B2

公开(公告)日：2021-11-16

申请号：US16454937

申请日：2019-06-27

Applicant: Creatv MicroTech, Inc.

Inventor： Olga Makarova ,  Cha-Mei Tang ,  Peixuan Zhu ,  Shuhong Li ,  Daniel Adams ,  Platte T. Amstutz

IPC: G01N33/50 ,  B01D71/46 ,  G01N1/40 ,  B01L3/00 ,  B01D39/16 ,  B01D29/00 ,  B01L9/00

Abstract: A microfilter having a hydrophilic surface and suited for size-based capture and analysis of cells, such as circulating cancer cells, from whole blood and other human fluids is disclosed. The filter material is photo-definable, allowing the formation of precision pores by UV lithography. Exemplary embodiments provide a device that combines a microfilter with 3D nanotopography in culture scaffolds that mimic the 3D in vivo environment to better facilitate growth of captured cells.

公开(公告)号：US20150168381A1

公开(公告)日：2015-06-18

申请号：US14404403

申请日：2013-05-31

Applicant: CREATV MICROTECH, INC.

Inventor： Daniel Adams ,  Cha-Mei Tang ,  Olga Makarova ,  Peixuan Zhu ,  Shuhong Li ,  Platte Amstutz

IPC: G01N33/50

CPC classification number: G01N33/5091 ,  G01N33/57488 ,  G01N2800/52

Abstract: A new sensitive cell biomarker of solid tumors is identified in blood. This biomarker can be used to determine presence of carcinomas, rapid determination of treatment response, early detection of cancer, early detection of cancer recurrence, and may be used to determine therapy.

Abstract translation: 在血液中鉴定出实体瘤的新敏感细胞生物标志物。 该生物标志物可用于确定癌的存在，快速测定治疗反应，早期检测癌症，早期检测癌症复发，并可用于确定治疗。