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    Pathogenic microorganism sample collection and preservation device with protection function
    2.
    发明授权
    Pathogenic microorganism sample collection and preservation device with protection function 有权

    公开(公告)号：US11970727B1

    公开(公告)日：2024-04-30

    申请号：US18148562

    申请日：2022-12-30

    申请人： Yanhua Xie ,  Yansen Xie ,  Mitchell Brown

    发明人： Yanhua Xie ,  Yansen Xie ,  Mitchell Brown

    IPC分类号： C12Q1/02 ,  B01L3/00

    CPC分类号： C12Q1/02 ,  B01L3/50 ,  B01L3/565 ,  B01L2300/024 ,  B01L2300/0609 ,  B01L2300/0848 ,  B01L2300/0861

    摘要： The present disclosure discloses a pathogenic microorganism sample collection and preservation device with a protection function, including a sampler and a preservation container; the sampler and the preservation container are both packaged by independent aseptic packaging bags. The sampler includes a sample collection mechanism, a holding mechanism, and a protection mechanism arranged between the sample collection mechanism and the holding mechanism. Before sample collection, the preservation container is sealed by an assorted sealing cover. The sample collection and preservation device of the present disclosure is convenient for holding and flexible adjustment of a sample collection angle. The protection mechanism between the holding mechanism and the sample collection mechanism plays a role of shielding, thus avoiding the problem of cross contamination. In addition, the sampler and the preservation container are matched ingeniously, so that a reliable sealing effect is achieved, which avoids spilling or contamination during sample preservation and transferring.

    Vitrification Device with Textured Surface for Sealing
    3.
    发明公开
    Vitrification Device with Textured Surface for Sealing 审中-公开

    公开(公告)号：US20240123442A1

    公开(公告)日：2024-04-18

    申请号：US18485495

    申请日：2023-10-12

    申请人： Cook Medical Technologies LLC

    发明人： Jorge L. Jimenez-Rios ,  Victor Havill ,  Donald R. Sandmore

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50 ,  B01L2200/0689

    摘要： A sealable container for preservation of a biological sample is provided. The sealable container includes a cap and an elongate body. The cap has a proximal open end and a distal end with a lumen extending from the proximal open end to the distal end. The elongate body extends from a handle portion to a specimen portion, where the specimen portion is configured to receive a biological sample thereon. The elongate body further includes a closure portion disposed between the handle portion and the specimen portion, where the closure portion is configured to make surface to surface contact with the cap when the specimen portion of the elongate body is fully inserted within the lumen of the cap. At least one of an inner surface of the cap and an outer surface of the elongate body includes a textured area with a textured surface finish.

    Methods, compositions, and devices involving pseudoknot formation
    5.
    发明授权
    Methods, compositions, and devices involving pseudoknot formation 有权

    公开(公告)号：US11892381B2

    公开(公告)日：2024-02-06

    申请号：US16619756

    申请日：2018-06-05

    申请人： Maumita Mandal

    发明人： Maumita Mandal

    IPC分类号： G01N1/22 ,  B01L3/00 ,  C12N15/113 ,  C12N15/115

    CPC分类号： G01N1/2226 ,  B01L3/50 ,  C12N15/113 ,  C12N15/115 ,  B01L2300/025 ,  B01L2300/0663 ,  C12N2310/531

    摘要： Naturally occurring RNA pseudoknots fold into many topologies, yet their formation is poorly understood. Herein, by using high-resolution single-molecule force spectroscopy, the folding pathways of the H-type pseudoknot found in the preQ1-riboswitch in B. subtilis were investigated By holding a single riboswitch RNA molecule in the optical-trap, the structural rearrangements as the end-to-end distance change along the pulling direction, x at a force, F were followed. The data reveal a multistate folding, wherein the intermediate hairpin undergoes a unidirectional conformational switching in the presence of ligand to form the pseudoknot receptor. Specifically-designed mutant RNAs resisted the switching mechanism and resulted in a significantly reduced pseudoknot population (4.5%) compared to the wild-type (100%). The free-energy landscape highlighted two kinetic barriers (ΔG±) that interrupt the folding pathway. By coupling the exothermic ligand-binding reaction (ΔGbinding=−16 kT) to the folding events, the nascent transcript ensures successful barrier crossing, thus favoring the pseudoknot conformation.

    Automatic Analyzer
    6.
    发明公开
    Automatic Analyzer 审中-公开

    公开(公告)号：US20230251279A1

    公开(公告)日：2023-08-10

    申请号：US18011971

    申请日：2021-03-11

    申请人： Hitachi High-Tech Corporation

    发明人： Takahiro KUMAGAI ,  Yoichiro SUZUKI ,  Syotaro SAGAWA ,  Takushi MIYAKAWA

    IPC分类号： G01N35/00 ,  B01L3/00 ,  G01N35/10

    CPC分类号： G01N35/00613 ,  B01L3/50 ,  G01N35/10

    摘要： An object of the present invention is to provide an automatic analyzer that can decrease the frequency of cleaning as compared to the past by suppressing breeding of bacteria and the like in a buffer tank as compared to the past and can reduce maintenance work time of an operator. Provided is an automatic analyzer comprising: an analysis module 20 that analyzes a specimen; and a supply system that supplies a liquid to the analysis module 20, wherein the supply system includes: a buffer tank 3 that temporarily stores pure water supplied from a pure water production device 50 outside of the analyzer; a supply channel 7 through which the pure water in the buffer tank 3 is sent to the analysis module 20; a circulation water pump 4 that feeds the pure water in the buffer tank 3; a circulation channel 8 through which the pure water discharged from the circulation water pump 4 is returned to the buffer tank 3; a sterilization mechanism 5 that sterilizes the pure water in the supply system; and a control unit 30 that controls an operation of each device in the supply system.

    BIOPSY CONTAINER ASSEMBLY
    7.
    发明公开
    BIOPSY CONTAINER ASSEMBLY 审中-公开

    公开(公告)号：US20230226537A1

    公开(公告)日：2023-07-20

    申请号：US18001755

    申请日：2021-06-15

    申请人： CANOS SOCIETA' A RESPONSABILITA' LIMITATA SEMPLIFICATA

    发明人： Giorgio GUERCIO

    IPC分类号： B01L3/00

    CPC分类号： B01L3/50 ,  B01L3/523 ,  B01L2300/047 ,  B01L2300/0672 ,  B01L2300/0832

    摘要： A biopsy container assembly having a container with a lower chamber suitable for containing a buffer liquid, and a cap coupled with the container. The cap being provided with a chamber that contains a biopsy liquid sealed by a membrane, and a crown with a toothing-suitable for tearing off the membrane of the cap. The crown is also suitable for being disposed in the container in an initial position, wherein the toothing is directed downwards in order not to interfere with the membrane of the cap when the cap is closed on the container, and in an operating position, wherein the toothing is directed upwards in order to tear off the membrane of the cap when the cap is closed on the container.

    IMPROVED URINE TEST CONTAINER FOR URINE SEPARATION AND INFECTION CONTROL
    9.
    发明申请
    IMPROVED URINE TEST CONTAINER FOR URINE SEPARATION AND INFECTION CONTROL 审中-公开

    公开(公告)号：US20180317891A1

    公开(公告)日：2018-11-08

    申请号：US15774002

    申请日：2016-11-07

    申请人： THE CATHOLIC UNIVERSITY OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION

    发明人： CHANG UK KIM

    IPC分类号： A61B10/00 ,  B01L3/00

    CPC分类号： A61B10/007 ,  B01L3/50 ,  B65D25/04 ,  G01N33/493

    摘要： The present invention relates to a urine test container, Specifically, the present invention relates to a container capable of readily separating first urine while receiving whole urine in order to remove the inconvenience of discarding the first urine and putting the remaining urine in a container in a medical institution such as a hospital and a health care institution, because the quality of a test is decreased due to a plurality of epithelial cells included in the first urine in a urine test. A container for collecting the urine of a subject, which is one aspect of the present invention, comprises: a container for collecting urine; and a barrier film located within the container so as to divide the inside of the container, thereby separating a predetermined amount of the first urine, which is first collected from the urine, and the second urine differing from the first urine, wherein only the second urine is used in the urine test of the subject and the first urine and the second urine can be separated using the barrier film.