公开(公告)号：US20150297626A1

公开(公告)日：2015-10-22

申请号：US14440826

申请日：2013-11-06

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Rick Jan van Haastert ,  Petronella Innocentia van Noort ,  Grégoire Pierre André Prevost ,  Willemijn Maria Gommans ,  Roeland Quirinus Jozef Schaapveld ,  Matheus Maria De Gunst ,  Iman Johannes Schultz ,  Eugene Berezikov

IPC: A61K31/713 ,  A61K31/519 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506

CPC classification number: A61K31/713 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  A61K2300/00

Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的组合的治疗用途。

公开(公告)号：US20140005251A1

公开(公告)日：2014-01-02

申请号：US13933526

申请日：2013-07-02

Applicant: InteRNA Technologies B.V.

Inventor： Sanne WEIJZEN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Meriem BOURAJJAJ ,  Rick Jan VAN HAASTERT ,  Arjan Willem GRIFFIOEN ,  Judith Rosina VAN BEIJNUM ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Andreas Alphons Franciscus Ludovicus VAN PUIJENBROEK ,  Willemijn Maria GOMMANS ,  Negar BABAE ,  Petronella Innocentia VAN NOORT

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US20230136088A1

公开(公告)日：2023-05-04

申请号：US17904864

申请日：2021-02-26

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanaz YAHYANEJAD ,  Bryony TELFORD ,  Marion VAN DEN BOSCH ,  Mir Farshid ALEMDEHY ,  Matheus Maria DE GUNST ,  Laurens Adrianus Hendricus VAN PINXTEREN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Michel JANICOT

IPC: C12N15/113 ,  A61K31/7105 ,  A61P35/00

Abstract: The invention relates to the use of miRNA-193a for regulating gene expression, particularly it relates to the use of miRNA-193a as a CRT agonist, promoting the cell surface expression of CRT. This allows the advantageous treatment of cancers without or with low surface expression of CRT. The invention further relates to compositions comprising the miRNA for use in such treatment.

公开(公告)号：US20210315917A9

公开(公告)日：2021-10-14

申请号：US16760396

申请日：2018-11-02

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Eljo Y. VAN BATTUM ,  Vamshi R. VANGOOR ,  Alwin A.H.A. DERIJCK ,  Roeland Quirinus Jozef SCHAAPVELD ,  R. Jeroen PASTERKAMP

IPC: A61K31/713 ,  C12N15/113

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a neuronal deficiency or a disease and condition associated with neuronal deficiency.

公开(公告)号：US10174314B2

公开(公告)日：2019-01-08

申请号：US14367837

申请日：2012-12-20

Applicant: INTERNA TECHNOLOGIES B.V. ,  Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg

Inventor： Rudolf Henrikus Brakenhoff ,  Marlon Van Der Plas ,  Sanne Rosaly De Kemp ,  Willemijn Maria Gommans ,  Grégoire Pierre André Prevost ,  Roeland Quirinus Jozef Schaapveld ,  Francesco Cerisoli

IPC: C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.

公开(公告)号：US20170304348A1

公开(公告)日：2017-10-26

申请号：US15625945

申请日：2017-06-16

Applicant: INTERNA TECHNOLOGIES B.V. ,  KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemijn Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F.L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Pierre Andre Prevost

IPC: A61K31/7088 ,  C12N15/11 ,  C12Q1/68 ,  C12N15/113

CPC classification number: A61K31/7088 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US09161947B2

公开(公告)日：2015-10-20

申请号：US13603300

申请日：2012-09-04

Applicant: Roeland Quirinus Jozef Schaapveld ,  Gerardus Wihelmus Christiaan Theodoor Verhaegh ,  Jacobus Antonius Schalken ,  Andreas Alphons van Puijenbroek ,  Willemjin Maria Gommans ,  Sanne Weijzen

Inventor： Roeland Quirinus Jozef Schaapveld ,  Gerardus Wihelmus Christiaan Theodoor Verhaegh ,  Jacobus Antonius Schalken ,  Andreas Alphons van Puijenbroek ,  Willemjin Maria Gommans ,  Sanne Weijzen

IPC: C12N15/11 ,  C12Q1/68 ,  A61K31/7088 ,  A61K31/7105 ,  C12N15/113

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).

Abstract translation: 本发明涉及miRNA分子或其等同物的诊断和治疗用途，其中所述miRNA分子或其等同物的来源包含至少80个核苷酸，并且包含与SEQ ID NO所代表的基序具有至少98％同一性的基序 ：1或其与EMT（上皮至间质转化）相关的疾病和病症的来源。

公开(公告)号：US20150152499A1

公开(公告)日：2015-06-04

申请号：US14409947

申请日：2013-07-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Anton Jan Van Zonneveld ,  Jacques Duijs ,  Johan Kuiper ,  Thijs Jan Zweers ,  Johan Wouter Jukema ,  Eugene Berezikov

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules, complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.

Abstract translation: 由分离的核酸分子，其补体和/或其片段组成或由其组成的诊断组合，所述核酸分子，补体，等同物和/或片段由包含具有至少80％的序列同一性的序列组成或由其组成的序列表示 具有SEQ ID NO：1-92或49-140或其衍生物（即组a），b），c），d），e），f），g），h），i）或j）或亚组 ）及其用途。

公开(公告)号：US20130072545A1

公开(公告)日：2013-03-21

申请号：US13603300

申请日：2012-09-04

Applicant: Roeland Quirinus Jozef Schaapveld ,  Gerardus Wilhelmus Christiaan Theodoor Verhaegh ,  Jacobus Antonius Schalken ,  Andreas Alphons Franciscus Ludovicus Van Puijenbroek ,  Willemjin Maria Gommans ,  Sanne Weijzen

Inventor： Roeland Quirinus Jozef Schaapveld ,  Gerardus Wilhelmus Christiaan Theodoor Verhaegh ,  Jacobus Antonius Schalken ,  Andreas Alphons Franciscus Ludovicus Van Puijenbroek ,  Willemjin Maria Gommans ,  Sanne Weijzen

IPC: A61K31/7088 ,  C12Q1/68

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).

Abstract translation: 本发明涉及miRNA分子或其等同物的诊断和治疗用途，其中所述miRNA分子或其等同物的来源包含至少80个核苷酸，并且包含与SEQ ID NO所代表的基序具有至少98％同一性的基序 ：1或其与EMT（上皮至间质转化）相关的疾病和病症的来源。

公开(公告)号：US10023868B2

公开(公告)日：2018-07-17

申请号：US15227832

申请日：2016-08-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanne Weijzen ,  Roeland Quirinus Jozef Schaapveld ,  Meriem Bourajjaj ,  Rick Jan Van Haastert ,  Arjan Willem Griffioen ,  Judith Rosina Van Beijnum ,  Edwin Pieter Johan Gerard Cuppen ,  Eugene Berezikov ,  Andreas Alphons Franciscus Ludovicus Van Puijenbroek ,  Willemijn Maria Gommans ,  Negar Babae ,  Petronella Innocentia Van Noort

IPC: C12N15/113 ,  C12Q1/68 ,  A61P35/00 ,  C12Q1/6883 ,  C12N7/00 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.