公开(公告)号：US11497762B2

公开(公告)日：2022-11-15

申请号：US16760396

申请日：2018-11-02

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Eljo Y. Van Battum ,  Vamshi R. Vangoor ,  Alwin A. H. A. Derijck ,  Roeland Quirinus Jozef Schaapveld ,  R. Jeroen Pasterkamp

IPC: A61K31/713 ,  C12N15/113 ,  C12Q1/68

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a neuronal deficiency or a disease and condition associated with neuronal deficiency.

公开(公告)号：US09682095B2

公开(公告)日：2017-06-20

申请号：US13734414

申请日：2013-01-04

Applicant: InteRNA Technologies B.V. ,  Koninlijke Nederlandse Akademie van Wetenschappen

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemijn Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F. L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Pierre Andre Prevost

IPC: C12N15/11 ,  C12Q1/68 ,  A61K31/7088 ,  C12N15/113

CPC classification number: A61K31/7088 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US09441222B2

公开(公告)日：2016-09-13

申请号：US13933526

申请日：2013-07-02

Applicant: InteRNA Technologies B.V.

Inventor： Sanne Weijzen ,  Roeland Quirinus Jozef Schaapveld ,  Meriem Bourajjaj ,  Rick Jan Van Haastert ,  Arjan Willem Griffioen ,  Judith Rosina Van Biejnum ,  Edwin Pieter Johan Gerard Cuppen ,  Eugene Berezikov ,  Andreas Alphons Franciscus Ludovicus Van Piujenbroek ,  Willemijn Maria Gommans ,  Negar Babae ,  Petronella Innocentia Van Noort

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US10583149B2

公开(公告)日：2020-03-10

申请号：US15625945

申请日：2017-06-16

Applicant: INTERNA TECHNOLOGIES B.V. ,  KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemijn Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F. L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Pierre Andre Prevost

IPC: C12N15/11 ,  A61K31/7088 ,  C12N15/113 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US10201556B2

公开(公告)日：2019-02-12

申请号：US14440826

申请日：2013-11-06

Applicant: InteRNA Technologies B.V.

Inventor： Rick Jan van Haastert ,  Petronella Innocentia van Noort ,  Grégoire Pierre André Prevost ,  Willemijn Maria Gommans ,  Roeland Quirinus Jozef Schaapveld ,  Matheus Maria De Gunst ,  Iman Johannes Schultz ,  Eugene Berezikov

IPC: C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  C12N15/113

Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US20150297626A1

公开(公告)日：2015-10-22

申请号：US14440826

申请日：2013-11-06

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Rick Jan van Haastert ,  Petronella Innocentia van Noort ,  Grégoire Pierre André Prevost ,  Willemijn Maria Gommans ,  Roeland Quirinus Jozef Schaapveld ,  Matheus Maria De Gunst ,  Iman Johannes Schultz ,  Eugene Berezikov

IPC: A61K31/713 ,  A61K31/519 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506

CPC classification number: A61K31/713 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  A61K2300/00

Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的组合的治疗用途。

公开(公告)号：US10023868B2

公开(公告)日：2018-07-17

申请号：US15227832

申请日：2016-08-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanne Weijzen ,  Roeland Quirinus Jozef Schaapveld ,  Meriem Bourajjaj ,  Rick Jan Van Haastert ,  Arjan Willem Griffioen ,  Judith Rosina Van Beijnum ,  Edwin Pieter Johan Gerard Cuppen ,  Eugene Berezikov ,  Andreas Alphons Franciscus Ludovicus Van Puijenbroek ,  Willemijn Maria Gommans ,  Negar Babae ,  Petronella Innocentia Van Noort

IPC: C12N15/113 ,  C12Q1/68 ,  A61P35/00 ,  C12Q1/6883 ,  C12N7/00 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

公开(公告)号：US09944932B2

公开(公告)日：2018-04-17

申请号：US14849777

申请日：2015-09-10

Applicant: InteRNA Technologies B.V.

Inventor： Roeland Quirinus Jozef Schaapveld ,  Gerardus Wilhelmus Christiaan Theodoor Verhaegh ,  Jacobus Antonius Schalken ,  Andreas Alphons Franciscus Ludovicus van Puijenbroek ,  Willemijn Maria Gommans ,  Sanne Weijzen

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/7105 ,  A61K31/7088 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).

公开(公告)号：US20130109741A1

公开(公告)日：2013-05-02

申请号：US13734414

申请日：2013-01-04

Applicant: InteRNA Technologies B.V. ,  Koninklijke Nederlandse Akademie van Wetensch

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemjin Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F. L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Piere Andre Prevost

IPC: A61K31/7088 ,  C12Q1/68

CPC classification number: A61K31/7088 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US10174314B2

公开(公告)日：2019-01-08

申请号：US14367837

申请日：2012-12-20

Applicant: INTERNA TECHNOLOGIES B.V. ,  Vereniging Voor Christelijk Hoger Onderwijs, Wetenschappelijk Onderzoek En Patientenzorg

Inventor： Rudolf Henrikus Brakenhoff ,  Marlon Van Der Plas ,  Sanne Rosaly De Kemp ,  Willemijn Maria Gommans ,  Grégoire Pierre André Prevost ,  Roeland Quirinus Jozef Schaapveld ,  Francesco Cerisoli

IPC: C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA-323, miRNA-342, miRNA-326, miRNA-371, miRNA-3157 and/or miRNA-345 molecule, an equivalent or a source thereof in a disease and condition associated with a squamous cell carcinoma such as head and neck cancer or a preneoplastic mucosal change.