公开(公告)号：US20170304348A1

公开(公告)日：2017-10-26

申请号：US15625945

申请日：2017-06-16

Applicant: INTERNA TECHNOLOGIES B.V. ,  KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemijn Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F.L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Pierre Andre Prevost

IPC: A61K31/7088 ,  C12N15/11 ,  C12Q1/68 ,  C12N15/113

CPC classification number: A61K31/7088 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US20150152499A1

公开(公告)日：2015-06-04

申请号：US14409947

申请日：2013-07-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Anton Jan Van Zonneveld ,  Jacques Duijs ,  Johan Kuiper ,  Thijs Jan Zweers ,  Johan Wouter Jukema ,  Eugene Berezikov

IPC: C12Q1/68

CPC classification number: C12Q1/6883 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/178

Abstract: A diagnostic portfolio comprising or consisting of isolated nucleic acid molecules, their complement and/or fragments thereof, said nucleic acid molecules, complements, equivalents and/or fragments thereof being represented by sequences comprising or consisting of sequences having at least 80% of sequence identity with SEQ ID NO:1-92, or 49-140 or derived thereof (i.e. groups a), b), c), d), e), f), g), h), i) or j) or subgroups thereof) and their uses.

Abstract translation: 由分离的核酸分子，其补体和/或其片段组成或由其组成的诊断组合，所述核酸分子，补体，等同物和/或片段由包含具有至少80％的序列同一性的序列组成或由其组成的序列表示 具有SEQ ID NO：1-92或49-140或其衍生物（即组a），b），c），d），e），f），g），h），i）或j）或亚组 ）及其用途。

公开(公告)号：US10583149B2

公开(公告)日：2020-03-10

申请号：US15625945

申请日：2017-06-16

Applicant: INTERNA TECHNOLOGIES B.V. ,  KONINKLIJKE NEDERLANDSE AKADEMIE VAN WETENSCHAPPEN

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemijn Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F. L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Pierre Andre Prevost

IPC: C12N15/11 ,  A61K31/7088 ,  C12N15/113 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US10201556B2

公开(公告)日：2019-02-12

申请号：US14440826

申请日：2013-11-06

Applicant: InteRNA Technologies B.V.

Inventor： Rick Jan van Haastert ,  Petronella Innocentia van Noort ,  Grégoire Pierre André Prevost ,  Willemijn Maria Gommans ,  Roeland Quirinus Jozef Schaapveld ,  Matheus Maria De Gunst ,  Iman Johannes Schultz ,  Eugene Berezikov

IPC: C12N15/11 ,  A61K48/00 ,  C07H21/02 ,  C07H21/04 ,  A61K31/713 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  C12N15/113

Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US20150297626A1

公开(公告)日：2015-10-22

申请号：US14440826

申请日：2013-11-06

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Rick Jan van Haastert ,  Petronella Innocentia van Noort ,  Grégoire Pierre André Prevost ,  Willemijn Maria Gommans ,  Roeland Quirinus Jozef Schaapveld ,  Matheus Maria De Gunst ,  Iman Johannes Schultz ,  Eugene Berezikov

IPC: A61K31/713 ,  A61K31/519 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506

CPC classification number: A61K31/713 ,  A61K31/4184 ,  A61K31/437 ,  A61K31/506 ,  A61K31/519 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  A61K2300/00

Abstract: The invention relates to the therapeutic use of a combination in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的组合的治疗用途。

公开(公告)号：US10023868B2

公开(公告)日：2018-07-17

申请号：US15227832

申请日：2016-08-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanne Weijzen ,  Roeland Quirinus Jozef Schaapveld ,  Meriem Bourajjaj ,  Rick Jan Van Haastert ,  Arjan Willem Griffioen ,  Judith Rosina Van Beijnum ,  Edwin Pieter Johan Gerard Cuppen ,  Eugene Berezikov ,  Andreas Alphons Franciscus Ludovicus Van Puijenbroek ,  Willemijn Maria Gommans ,  Negar Babae ,  Petronella Innocentia Van Noort

IPC: C12N15/113 ,  C12Q1/68 ,  A61P35/00 ,  C12Q1/6883 ,  C12N7/00 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

公开(公告)号：US20130109741A1

公开(公告)日：2013-05-02

申请号：US13734414

申请日：2013-01-04

Applicant: InteRNA Technologies B.V. ,  Koninklijke Nederlandse Akademie van Wetensch

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemjin Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F. L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Piere Andre Prevost

IPC: A61K31/7088 ,  C12Q1/68

CPC classification number: A61K31/7088 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

Abstract translation: 本发明涉及在与黑素瘤或与活化的BRAF途径相关的疾病或病症相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US09682095B2

公开(公告)日：2017-06-20

申请号：US13734414

申请日：2013-01-04

Applicant: InteRNA Technologies B.V. ,  Koninlijke Nederlandse Akademie van Wetenschappen

Inventor： Eugene Berezikov ,  Jos Bernard Poell ,  Willemijn Maria Gommans ,  Rick Jan van Haastert ,  Andreas Alphons F. L. van Puijenbroek ,  Roeland Quirinus Jozef Schaapveld ,  Gregoire Pierre Andre Prevost

IPC: C12N15/11 ,  C12Q1/68 ,  A61K31/7088 ,  C12N15/113

CPC classification number: A61K31/7088 ,  C12N15/111 ,  C12N15/113 ,  C12N15/1135 ,  C12N2310/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/31 ,  C12N2330/10 ,  C12Q1/6809

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with melanoma or a disease or a condition associated with activated BRAF pathway.

公开(公告)号：US09441222B2

公开(公告)日：2016-09-13

申请号：US13933526

申请日：2013-07-02

Applicant: InteRNA Technologies B.V.

Inventor： Sanne Weijzen ,  Roeland Quirinus Jozef Schaapveld ,  Meriem Bourajjaj ,  Rick Jan Van Haastert ,  Arjan Willem Griffioen ,  Judith Rosina Van Biejnum ,  Edwin Pieter Johan Gerard Cuppen ,  Eugene Berezikov ,  Andreas Alphons Franciscus Ludovicus Van Piujenbroek ,  Willemijn Maria Gommans ,  Negar Babae ,  Petronella Innocentia Van Noort

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。