公开(公告)号：US4209319A

公开(公告)日：1980-06-24

申请号：US692066

申请日：1976-06-02

Applicant: Georg Pissiotas ,  Dieter Duerr ,  Otto Rohr

Inventor： Georg Pissiotas ,  Dieter Duerr ,  Otto Rohr

IPC: A01N37/52 ,  C07C123/00 ,  A01N9/20

CPC classification number: A01N37/52

Abstract: New phenylformamidine compounds are disclosed, which have the structure ##STR1## in which R is an unsaturated, halogenated radical, particularly a propenyl, butenyl or benzyl radical, mono- or disubstituted by fluorine chlorine or bromine. These compounds and their acid addition salts possess herbicidal properties.

Abstract translation: 公开了新的苯基甲脒化合物，其具有其中R是不饱和卤化基团，特别是丙烯基，丁烯基或苄基的结构，其被氟氯或溴单取代或二取代。 这些化合物及其酸加成盐具有除草性。

公开(公告)号：US4206142A

公开(公告)日：1980-06-03

申请号：US949332

申请日：1978-10-06

Applicant: William L. Matier ,  William T. Comer

Inventor： William L. Matier ,  William T. Comer

IPC: C07D285/18 ,  C07C123/00

CPC classification number: C07D285/18

Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics, and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

Abstract translation: 通过用碱处理苯乙烯基磺酰脒制备苯乙烯基脒。 苯乙烯胺可有效预防血小板聚集和镇痛作用。 本发明的化合物还可用作抗惊厥药，利尿剂和抗高血压药。 用作苯乙烯基脒基前体的本发明的苯乙烯基磺酰脒也具有镇痛特性。 本发明的苯乙烯基脒的实例是4-氨基-N-（4-氨基苯乙烯基）苄脒和N-（3,4-二氯苯乙烯基）乙脒。 苯乙烯基磺酰脒的实例是N-（苯乙烯基磺酰基）乙脒。

公开(公告)号：US4096183A

公开(公告)日：1978-06-20

申请号：US825996

申请日：1977-08-19

Applicant: William L. Matier ,  William T. Comer

Inventor： William L. Matier ,  William T. Comer

IPC: A61K31/155 ,  A61K31/245 ,  A61K31/255 ,  A61P7/02 ,  A61P9/12 ,  A61P25/04 ,  C07C67/00 ,  C07C239/00 ,  C07C257/10 ,  C07C301/00 ,  C07C303/40 ,  C07C311/46 ,  C07C313/00 ,  C07C315/04 ,  C07C317/32 ,  C07C143/38 ,  C07C123/00 ,  C07C143/40

CPC classification number: A61K31/155

Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

Abstract translation: 通过用碱处理苯乙烯基磺酰脒制备苯乙烯基脒。 苯乙烯胺可有效预防血小板聚集和镇痛作用。 本发明的化合物还可用作抗惊厥药，利尿剂和抗高血压药。 用作苯乙烯基脒基前体的本发明的苯乙烯基磺酰脒也具有镇痛特性。 本发明的苯乙烯基脒的实例是4-氨基-N-（4-氨基苯乙烯基）苄脒和N-（3,4-二氯苯乙烯基）乙脒。 苯乙烯基磺酰脒的实例是N-（苯乙烯基磺酰基）乙脒。

公开(公告)号：US4052455A

公开(公告)日：1977-10-04

申请号：US601563

申请日：1975-08-04

Applicant: William L. Matier ,  William T. Comer

Inventor： William L. Matier ,  William T. Comer

IPC: A61K31/155 ,  C07C123/00

CPC classification number: A61K31/155 ,  Y10S514/822

Abstract: Styrylamidines are prepared by treating styrylsulfonylamidines with base. The styrylamidines are effective in the prevention of aggregation of blood platelets and as analgesics. Compounds of the invention are also useful as anticonvulsants, diuretics and antihypertensive agents. The styrylsulfonylamidines of the invention which serve as precursors to the styrylamidines also have analgesic properties. Illustrative of the styrylamidines of the present invention are 4-amino-N-(4-aminostyryl)benzamidine and N-(3,4-dichlorostyryl)acetamidine. An example of a styrylsulfonylamidine is N-(styrylsulfonyl)acetamidine.

公开(公告)号：US3933912A

公开(公告)日：1976-01-20

申请号：US486705

申请日：1974-07-08

Applicant: Earl R. Bockstahler

Inventor： Earl R. Bockstahler

IPC: C07C259/14 ,  C07C123/00

CPC classification number: C07C259/14

Abstract: Substituted phenylthioamidine compounds such as 2-(4-chlorophenylthio)acetamidine; 2-(4-chlorophenylthio)-acetamidoxime; and their pharmaceutically acceptable salts are prepared by the reaction of a substituted phenylthioacetonitrile with hydroxylamine hydrochloride or with methanol followed by ammonium chloride. The compounds have antimicrobial activity and also inhibit ADP-induced aggregation of blood platelets.

Abstract translation: 取代的苯基硫代脒化合物如2-（4-氯苯硫基）乙脒; 2-（4-氯苯硫基） - 乙酰胺肟; 其药学上可接受的盐通过取代的苯基硫代乙腈与羟胺盐酸盐或甲醇反应，随后用氯化铵反应来制备。 该化合物具有抗微生物活性，也抑制ADP诱导的血小板聚集。

公开(公告)号：US3929884A

公开(公告)日：1975-12-30

申请号：US45601774

申请日：1974-03-29

Applicant: SANDOZ AG

Inventor： SIMPSON WILLIAM R J

IPC: C07D243/08 ,  C07D401/04 ,  C07C123/00

CPC classification number: C07D401/04 ,  C07D243/08 ,  Y10S514/866 ,  Y10S514/909

Abstract: Compounds of the formula

WHEREIN R is alkyl of 1 to 6 carbon atoms, EACH X is independently alkyl of 1 to 4 carbon atoms, alkoxy of 1 to 4 carbon atoms or halo, and M IS 0, 1 OR 2, AND PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALTS THEREOF, ARE USEFUL AS ANTI-OBESITY AND ANTI-DIABETIC AGENTS. They are synthesized by reacting a 2-alkyl-5-arylisoxazolium salt with ethylene diamine to obtain a compound of the formula

or a tautomer thereof, wherein R, X and m are as defined above, which is then cyclized with a strong acid.

Abstract translation: 式WHEREIN R的化合物是具有1至6个碳原子的烷基，每个X独立地是1至4个碳原子的烷基，1至4个碳原子的烷氧基或卤素，M IS 0，1 OR 2和药物可接受的酸 其添加量为有用的抗生素和抗糖尿病药物。 它们通过2-烷基-5-芳基异恶唑鎓盐与乙二胺反应得到式OH化合物：H 2 N-CH 2 CH 2 -NH-C-CH = C PARALLEL N 2，R或其互变异构体，其中R， X和m如上所定义，然后用强酸环化。

公开(公告)号：US3929883A

公开(公告)日：1975-12-30

申请号：US34446173

申请日：1973-03-23

Applicant: CIBA GEIGY CORP

Inventor： DURR DIETER ,  PISSIOTAS GEORG

IPC: A01N47/10 ,  A01N20060101 ,  A01N37/52 ,  A01N57/00 ,  A01P7/02 ,  C07D20060101 ,  C08G20060101 ,  C07C123/00

Abstract: Compounds of the formula

WHEREIN R1 represents alkyl having 1 to 4 carbon atoms, alkenyl having 3 to 5 carbon atoms, or alkynyl having 3 to 6 carbon atoms, R2 represents hydrogen, alkyl having 1 to 4 carbon atoms, alkenyl having 3 to 5 carbon atoms, or alkynyl having 3 to 6 carbon atoms, R3 represents alkyl having 1 to 4 carbon atoms, R4 represents alkyl having 1 to 4 carbon atoms, and R5 represents hydrogen, or alkyl having 1 to 4 carbon atoms, and X represents an inorganic or organic acid radical and their acid addition salts, process for the manufacture of these compounds, compositions containing these compounds as active ingredients and use of these compounds for the control of parasitic pests on domestic and productive animals.

Abstract translation: 式WHEREIN R1的化合物表示具有1至4个碳原子的烷基，具有3至5个碳原子的烯基或具有3至6个碳原子的炔基，R 2表示氢，具有1至4个碳原子的烷基，具有3至5个碳原子的烯基 原子或具有3至6个碳原子的炔基，R 3表示具有1至4个碳原子的烷基，R 4表示具有1至4个碳原子的烷基，R 5表示氢或具有1至4个碳原子的烷基，X表示无机 或有机酸基及其酸加成盐，制备这些化合物的方法，含有这些化合物作为活性成分的组合物和这些化合物用于控制家畜和生产动物的寄生虫害的方法。

公开(公告)号：US3906044A

公开(公告)日：1975-09-16

申请号：US51542974

申请日：1974-10-16

Applicant: KAO CORP

Inventor： AIGAMI KOJI ,  INAMOTO YOSHIAKI

IPC: C07C257/14 ,  C07C67/00 ,  C07C239/00 ,  C07C257/16 ,  C07C123/00

CPC classification number: C07D207/16

Abstract: Adamantyl amidines having the following formula (I) and their acid addition salts:

wherein Ad is adamantyl or bridgehead carbon atom-substituted alkyladamantyl, n is 0 or 1, and the amidino or amidinomethyl group is attached to a bridgehead carbon atom of the adamantane ring. The compounds are prepared by (1) reacting said nitrile compounds in the anhydrous state with an alcohol and an acid and then reacting the product with ammonia, or (2) reacting the corresponding nitrile compounds with a metal amide. The compounds are useful as anti-viral agents and as intermediates of adamantyl-substituted heterocyclic compounds.

Abstract translation: 具有下式（I）的金刚烷基脒及其酸加成盐：NH Ad（CH 2）n C ANGLE（I）NH 2其中Ad是金刚烷基或桥头堡碳原子取代的烷基金刚烷基，n是0或1，脒基或脒基甲基 附着在金刚烷环的桥头碳原子上。

公开(公告)号：US3887619A

公开(公告)日：1975-06-03

申请号：US36699973

申请日：1973-06-01

Applicant: UPJOHN CO

Inventor： RIZZO VICTOR L

IPC: A01N37/52 ,  C07C67/00 ,  C07C239/00 ,  C07C257/12 ,  C07C313/00 ,  C07C313/34 ,  C07C123/00

CPC classification number: A01N37/52

Abstract: Novel pesticidal N-hydrocarbylsulfenyl derivatives of N-alkylN''-aryl formamidines are disclosed with novel compositions thereof and methods of their use in controlling invertebrate pests, particularly insects and acarina. Certain of the novel compounds are particularly effective miticides.

Abstract translation: 公开了N-烷基-N'-芳基甲酰胺的新型农药N-烃基亚磺酰基衍生物及其用于控制​​无脊椎动物害虫，特别是昆虫和螨类的新型组合物及其方法。 某些新化合物是特别有效的杀螨剂。

公开(公告)号：US3879459A

公开(公告)日：1975-04-22

申请号：US46458474

申请日：1974-04-26

Applicant: UNIVERSAL OIL PROD CO

Inventor： GATTUSO MARION J

IPC: C08K5/44 ,  C07C123/00

CPC classification number: C08K5/44 ,  C08K5/43 ,  C08L21/00

Abstract: Novel compounds comprising substituted thioformamidines as exemplified by N,N''-diphenyl-N-cyclohexylthioformamidine are utilized to inhibit the premature vulcanization of vulcanizable rubber formulations.

Abstract translation: 用N，N'-二苯基-N-环己基硫代甲脒所例举的包含取代的硫代甲酰胺的新型化合物用于抑制硫化橡胶制剂的过早硫化。