公开(公告)号：US20210023141A1

公开(公告)日：2021-01-28

申请号：US17042763

申请日：2019-04-03

申请人： SYDDANSK UNIVERSITET ,  REGION SYDDANMARK

发明人： Søren Paludan SHEIKH ,  Ditte Caroline ANDERSEN ,  Charlotte Harken JENSEN

IPC分类号： A61K35/28 ,  A61P15/10 ,  G01N33/569 ,  A61P35/00 ,  A61P1/00

摘要： The present invention relates to an isolated CD31+ cell derived from adipose-derived regenerative cells (ADRC's), for use as a medicament. The invention also relates to compositions comprising such cells. In addition, the invention relates to methods for screening for the regenerative capacity of a population of adipose-derived regenerative cells (ADRC's).

公开(公告)号：US20210015779A1

公开(公告)日：2021-01-21

申请号：US16985072

申请日：2020-08-04

申请人： INNOVUS PHARMACEUTICALS, INC.

发明人： Bassam Damaj

IPC分类号： A61K31/198 ,  A61K9/48 ,  A61K33/00 ,  A61P15/10 ,  A61K31/4415 ,  A61K31/443 ,  A61K47/02 ,  A61K47/38

摘要： The invention provides compositions and unit dosage forms that are effective to improve sexual performance. Such compositions and unit dosage forms are useful to increase duration of sexual intercourse, satisfaction with sexual intercourse, and improve erectile function in men.

公开(公告)号：US20200345768A1

公开(公告)日：2020-11-05

申请号：US16865263

申请日：2020-05-01

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski ,  Sara Perez Ojalvo ,  Sarah Sylla

IPC分类号： A61K33/30 ,  A61K33/06 ,  A61K33/04 ,  A61K31/4402 ,  A61K31/198 ,  A61P15/10 ,  A61P19/08

摘要： The present application relates to zinc picolinate, magnesium picolinate and selenium methionine compositions and methods of use. The methods and compositions disclosed herein are particularly useful for optimizing antioxidant and hormone levels and improving bone mineral density.

公开(公告)号：US20200230143A1

公开(公告)日：2020-07-23

申请号：US16581058

申请日：2019-09-24

申请人： INNOVUS PHARMACEUTICALS, INC.

发明人： Bassam Damaj

IPC分类号： A61K31/519 ,  A61K45/06 ,  A61K36/67 ,  A61K9/00 ,  A61P15/10 ,  A61K31/4525 ,  A61K47/38 ,  A61K47/02 ,  A61K47/12

摘要： The invention provides compositions and methods that are effective to improve NO production in vivo and/or to increase NO levels in blood. Such compositions and methods may be useful to improve the effects of PDE5 inhibitors, for example, on erectile dysfunction or pulmonary hypertension.

公开(公告)号：US20200179457A1

公开(公告)日：2020-06-11

申请号：US16215982

申请日：2018-12-11

申请人： Joy Kong

发明人： Joy Kong

IPC分类号： A61K35/28 ,  A61P15/10 ,  A61P15/08 ,  A61B17/22 ,  A61B17/225 ,  A61H23/00

摘要： A method for enhancing male sexual wellness with shockwave therapy and stem cells promotes tissue repair and regeneration in or near the male penis, through the combinative effects of shockwave therapy and needle-free injection of a stem cell specimen on the penile surface of the penis. The method includes: preparing the male patient, both mentally and physically to receive stem cell therapy; applying shockwave therapy to the penis; developing a platelet-rich plasma preparation from the patient; introducing a stem cell specimen into a vial having a needle-free injector; introducing the platelet-rich plasma preparation into the vial; injecting, through the needle-free injector, the stem cell specimen and platelet-rich plasma preparation directly on penile surface from multiple positions, multiple depths, and multiple angles; reapplying shockwave therapy to the penis after a duration; and monitoring the patient for a post-procedure duration after administration of the stem cell specimen to the penis.

公开(公告)号：US20200155632A1

公开(公告)日：2020-05-21

申请号：US16635364

申请日：2018-08-02

申请人： KOLINPHARMA S.P.A.

发明人： Emanuele LUSENTI ,  Rita Paola PETRELLI ,  Arianna DI LORENZO ,  Valeria CURTI ,  Francesco CAPPITELLI

IPC分类号： A61K36/31 ,  A61K9/00 ,  A61K33/30 ,  A61K31/198 ,  A61K31/381 ,  A61K31/205 ,  A61K31/145 ,  A61P15/10 ,  A23L33/105 ,  A23L33/16 ,  A23L33/175

摘要： A pharmaceutical composition or food supplement is disclosed that is effective in the treatment and the prevention of male sexual disorders such as erectile dysfunction and the decrease in sexual desire, comprising the synergic combination of zinc, citrulline, lipoic acid and/or N-acetyl-L-carnitine, and possible further active ingredients.

公开(公告)号：US20200131200A1

公开(公告)日：2020-04-30

申请号：US16739363

申请日：2020-01-10

申请人： BRISTOL-MYERS SQUIBB COMPANY

发明人： Leon M. Smith, II ,  Vladimir Ladziata ,  Indawati De Lucca ,  Donald J.P. Pinto ,  Michael J. Orwat ,  Andrew K. Dilger ,  Kumar Balashnmuga Pabbisetty ,  Wu Yang ,  Scott A. Shaw ,  Peter W. Glunz ,  Manoranjan Panda

IPC分类号： C07D513/04 ,  A61P9/10 ,  A61P15/10 ,  C07D213/64 ,  C07D231/12 ,  C07D401/14 ,  C07D231/54 ,  C07D401/12 ,  C07D413/12 ,  C07D471/12 ,  C07D471/04 ,  C07D231/18

摘要： The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

公开(公告)号：US20200038415A1

公开(公告)日：2020-02-06

申请号：US16530138

申请日：2019-08-02

申请人： Enterin, Inc.

发明人： Denise Barbut ,  Michael Zasloft

IPC分类号： A61K31/575 ,  A61K9/00 ,  A61P15/10

摘要： The present application relates generally to compositions and methods for treating, preventing, and/or slowing the onset or progression of erectile dysfunction (ED) and a variety of symptoms related thereto with amino sterols or pharmaceutically acceptable salts or derivatives thereof.

公开(公告)号：US20190282610A1

公开(公告)日：2019-09-19

申请号：US15925198

申请日：2018-03-19

申请人： Glanotech Limited

发明人： Gioacchino Di Leo ,  Luciano Caglioti ,  Alberto Boffi ,  Luciana Mosca ,  Robert Giovanni Nisticò

IPC分类号： A61K33/00 ,  A61P15/10

摘要： A composition for releasing nitric oxide which provides a rapid release of nitrogen monoxide, and also allows formation of S-nitrosothiol compounds which provide a slower extended release of nitrogen monoxide. A composition kit includes two components that are mixed together to initiate nitric oxide release. The kit includes: a liquid phase comprising a solvent and at least one reducing agent; and a solid phase comprising a nitrate and/or nitrite salt, copper ions and at least one thiol. A method of treating sexual dysfunction involves topically applying the composition to an area of the subject to be treated.

公开(公告)号：US10335453B2

公开(公告)日：2019-07-02

申请号：US15446406

申请日：2017-03-01

申请人： Nymox Corporation

发明人： Paul Averback

IPC分类号： A61K38/10 ,  A61K45/06 ,  A61K9/00 ,  G09B7/10 ,  A61K38/17 ,  A61P15/10

摘要： The embodiments include methods of improving sexual function in a male with benign prostatic hyperplasia (BPH), using compositions containing compounds based on small peptides and a pharmaceutically acceptable carrier. The method includes, but is not limited to, administering the compounds intramuscularly, orally, intravenously, intraprostatically, intrathecally, intratumorally, intranasally, topically, transdermally, etc., either alone or conjugated to a carrier to a male in need thereof.