公开(公告)号：US20220023337A1

公开(公告)日：2022-01-27

申请号：US17224009

申请日：2021-04-06

申请人： NUTRITION 21, LLC

发明人： Vijaya Juturu ,  James R. Komorowski

IPC分类号： A61K33/24 ,  A61K31/415 ,  A61K31/4172 ,  A61K31/555

摘要： Provided herein are methods for treating, preventing, and improving conditions associated with cardiometabolic syndrome, by identifying a subject in need of treatment, prevention, or improvement of a condition associated with cardiometabolic syndrome, and providing a therapeutically effective amount of a composition comprising chromium and histidine, chromium histidinate complexes, or combinations thereof, to the individual.

公开(公告)号：US20190216821A1

公开(公告)日：2019-07-18

申请号：US16366936

申请日：2019-03-27

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A61K31/555 ,  A23L33/125 ,  A23L33/17 ,  A23L33/165 ,  A61K33/24 ,  A61K31/718 ,  A61K31/198 ,  A61K38/01 ,  A23L33/16 ,  A61K9/08 ,  A61K9/14 ,  A61K45/06 ,  A61K31/732 ,  A61K36/899

CPC分类号： A61K31/555 ,  A23L33/125 ,  A23L33/16 ,  A23L33/165 ,  A23L33/17 ,  A23V2002/00 ,  A61K9/08 ,  A61K9/14 ,  A61K31/198 ,  A61K31/718 ,  A61K31/732 ,  A61K33/24 ,  A61K36/899 ,  A61K38/018 ,  A61K45/06 ,  A61K2300/00

摘要： Administration of certain chromium complexes in combination with a starch provide unexpected benefits regarding increasing amino acid absorption, protein synthesis, exercise tolerance, lean muscle mass, skeletal muscle hypertrophy, muscle power, muscle endurance, muscle strength, FSR, and decreasing delayed onset muscle soreness, muscle protein breakdown, and fat mass.

公开(公告)号：US11865121B2

公开(公告)日：2024-01-09

申请号：US15427471

申请日：2017-02-08

申请人： Nutrition 21, LLC

发明人： James R. Komorowski

IPC分类号： A61K31/555 ,  A61K31/718 ,  A61K33/24 ,  A23L33/165 ,  A23L33/17 ,  A23L33/125 ,  A23L33/16 ,  A61K9/08 ,  A61K9/14 ,  A61K31/198 ,  A61K31/732 ,  A61K36/899 ,  A61K38/01 ,  A61K45/06

CPC分类号： A61K31/555 ,  A23L33/125 ,  A23L33/16 ,  A23L33/165 ,  A23L33/17 ,  A61K9/08 ,  A61K9/14 ,  A61K31/198 ,  A61K31/718 ,  A61K31/732 ,  A61K33/24 ,  A61K36/899 ,  A61K38/018 ,  A61K45/06 ,  A23V2002/00 ,  A61K31/718 ,  A61K2300/00 ,  A61K31/555 ,  A61K2300/00

摘要： Administration of certain chromium complexes in combination with a starch provide unexpected benefits regarding increasing amino acid absorption, protein synthesis, exercise tolerance, lean muscle mass, skeletal muscle hypertrophy, muscle power, muscle endurance, muscle strength, FSR, and decreasing delayed onset muscle soreness, muscle protein breakdown, and fat mass.

公开(公告)号：US20220265704A1

公开(公告)日：2022-08-25

申请号：US17672592

申请日：2022-02-15

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A61K33/06 ,  G01N33/50

摘要： The present application relates to the treatment of autism and autism spectrum disorders using biotin compositions.

公开(公告)号：US11938117B2

公开(公告)日：2024-03-26

申请号：US15693223

申请日：2017-08-31

申请人： NUTRITION 21, LLC

发明人： Deanna J. Nelson ,  James R. Komorowski

IPC分类号： A61K31/4188 ,  A61G3/00 ,  A61K8/19 ,  A61K8/67 ,  A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q7/00

CPC分类号： A61K31/4188 ,  A61K8/19 ,  A61K8/673 ,  A61K9/0053 ,  A61K9/2086 ,  A61K9/28 ,  A61K9/2806 ,  A61Q3/00 ,  A61Q5/002 ,  A61Q7/00 ,  A61K2800/58

摘要： The present application relates to magnesium biotinate compositions and methods of use. The methods and compositions disclosed herein are particularly useful for providing bioavailable biotin to mammals and treating or preventing symptoms of biotin deficiency.

公开(公告)号：US11931342B2

公开(公告)日：2024-03-19

申请号：US16855966

申请日：2020-04-22

申请人： NUTRITION 21, LLC

发明人： Deanna J. Nelson ,  James R. Komorowski

IPC分类号： A61K31/4188 ,  A61G3/00 ,  A61K8/19 ,  A61K8/67 ,  A61K9/00 ,  A61K9/20 ,  A61K9/28 ,  A61Q3/00 ,  A61Q5/00 ,  A61Q7/00

CPC分类号： A61K31/4188 ,  A61K8/19 ,  A61K8/673 ,  A61K9/0053 ,  A61K9/2086 ,  A61K9/28 ,  A61K9/2806 ,  A61Q3/00 ,  A61Q5/002 ,  A61Q7/00 ,  A61K2800/58

摘要： The present application relates to magnesium biotinate compositions and methods of use. The methods and compositions disclosed herein are particularly useful for providing bioavailable biotin to mammals and treating or preventing symptoms of biotin deficiency.

公开(公告)号：US11471435B2

公开(公告)日：2022-10-18

申请号：US17202011

申请日：2021-03-15

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A61K31/198 ,  A61P25/00 ,  A61K31/045

摘要： The present disclosure relates to the use of inositol-stabilized arginine silicate complexes (“ASI”) with the addition of free inositol (“I”) to form a composition ASI+I for improving cognitive functioning in humans, particularly video game players.

公开(公告)号：US11191735B2

公开(公告)日：2021-12-07

申请号：US15068350

申请日：2016-03-11

申请人： NUTRITION 21, LLC

发明人： James R Komorowski ,  Kazim Sahin

IPC分类号： A61K31/695 ,  A61K31/047 ,  A61K9/00 ,  A61K33/00 ,  A61K31/198

摘要： Methods for treating and/or preventing periodontal disease with arginine silicate are disclosed. Methods may include the steps of identifying an individual in need of treatment for, or in need of prevention of, periodontal disease and administering an effective amount of an arginine-silicate complex to said individual. Arginine silicate may also be used to ameliorate one or more symptoms of periodontal disease. In some aspects, arginine silicate may be used to restore gum health and/or stop or reverse recession of the gums and/or the loss of gum tissue in the oral cavity.

公开(公告)号：US11850219B2

公开(公告)日：2023-12-26

申请号：US17373731

申请日：2021-07-12

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A61K31/155 ,  A61K31/7004 ,  A61K33/00

CPC分类号： A61K31/155 ,  A61K31/7004 ,  A61K33/00

摘要： The present invention generally relates to compositions and methods for topical or transdermal delivery, for promoting wound healing, reducing scarring, and/or promoting hair growth. Specifically, the present disclosure is directed to a topical arginine silicate formulation that demonstrates surprising improvements in promoting hair growth.

公开(公告)号：US11622571B2

公开(公告)日：2023-04-11

申请号：US17390723

申请日：2021-07-30

申请人： NUTRITION 21, LLC

发明人： James R. Komorowski

IPC分类号： A23L33/175 ,  C07C279/14 ,  A23L2/52 ,  A23L3/46 ,  C07C277/08

摘要： Methods of manufacturing inositol-stabilized arginine-silicate (“ASI”) complexes with reduced or eliminated clumping and with increased solubility.