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公开(公告)号:US08450519B2
公开(公告)日:2013-05-28
申请号:US13422144
申请日:2012-03-16
申请人: Milan Soukup , Karl Reuter , Florian Stolz , Viktor Meier , Jofzsef Balint , Mark Kantor
发明人: Milan Soukup , Karl Reuter , Florian Stolz , Viktor Meier , Jofzsef Balint , Mark Kantor
CPC分类号: C07C235/34 , C07B2200/07 , C07C51/377 , C07C57/13 , C07C57/66 , C07C59/64 , C07C59/90
摘要: The invention relates to a process for preparing chiral octenoic acid derivatives, which constitute important intermediates in the preparation of medicament active ingredients, and also to novel intermediates which are used in the process for preparing the octenoic acid derivatives mentioned.
摘要翻译: 本发明涉及制备手性辛烯酸衍生物的方法,其在制备药物活性成分中构成重要的中间体,还涉及用于制备所述辛烯酸衍生物的方法中的新型中间体。
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公开(公告)号:US20070004938A1
公开(公告)日:2007-01-04
申请号:US11171966
申请日:2005-06-30
申请人: Miguel Guerra
发明人: Miguel Guerra
CPC分类号: C07C303/22 , C07C41/24 , C07C309/82 , C07C43/17
摘要: The present application provides a process to produce fluorinated vinyl ether by reacting a 2-alkoxypropionyl fluoride with a metal carbonate under anhydrous conditions in a stirred bed reactor at a temperature above the decarboxylation temperature of an intermediate carboxylate to produce a fluorinated vinyl ether. The process is carried out in the absence of solvent. With the process described, fluorinated vinyl ether of a high purity can be obtained in a high throughput manner.
摘要翻译: 本申请提供了一种在无水条件下在搅拌床反应器中在高于中间体羧酸酯的脱羧温度的温度下使2-烷氧基丙酰氟与金属碳酸盐反应生产氟化乙烯基醚的方法,以产生氟化乙烯基醚。 该方法在没有溶剂的情况下进行。 通过所述方法,可以高通量的方式获得高纯度的氟化乙烯基醚。
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公开(公告)号:US5041649A
公开(公告)日:1991-08-20
申请号:US68013
申请日:1987-06-29
申请人: Kaspar Bott
发明人: Kaspar Bott
IPC分类号: B01J27/125 , B01J27/00 , C07B61/00 , C07C51/00 , C07C51/58 , C07C53/38 , C07C57/64 , C07C61/13 , C07C67/00
CPC分类号: C07C51/58
摘要: Carbonyl halides I ##STR1## where R.sup.1 is H, alkyl, cycloalkyl, haloalkyl or halocycloalkyl,R.sup.2 and R.sup.3 are each alkyl, cycloalkyl, haloalkyl or halocycloalkyl and may furthermore be bonded to one another to form a 5-membered to 7-membered ring andis halogen,are prepared by reacting an alkyl halide II ##STR2## with carbon monoxide under superatmospheric pressure in the presence of a catalytic amount ofa) aluminum bromide and in the presence or absence of a solvent orb) aluminum chloride or bromide and in the presence of a halohydrocarbon and a carbonyl halide of the formula IIIR.sup.4 --CH.sub.2 --CO--Hal (III) where R.sup.4 is hydrogen or C.sub.1 -C.sub.4 -alkyl and Hal is halogen.
摘要翻译: 羰基卤化物I,其中R 1是H,烷基,环烷基,卤代烷基或卤代环烷基,R 2和R 3各自是烷基,环烷基,卤代烷基或卤代环烷基,并且还可以彼此键合形成5元至7元 环和卤素通过烷基卤化物II II与一氧化碳在超大气压下在催化量的溴化铝存在下和在存在或不存在溶剂的情况下反应制备,或b)氯化铝或 在卤代烃和式III的卤化碳R4-CH2-CO-Hal(Ⅲ)的存在下,其中R4是氢或C1-C4-烷基,Hal是卤素。
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公开(公告)号:US20070083064A1
公开(公告)日:2007-04-12
申请号:US11611183
申请日:2006-12-15
申请人: Kazuya OHARU , Takashi Okazoe , Eisuke Murotani , Kunio Watanabe , Masahiro Ito
发明人: Kazuya OHARU , Takashi Okazoe , Eisuke Murotani , Kunio Watanabe , Masahiro Ito
IPC分类号: C07C57/64
CPC分类号: C07C61/15 , C07C51/58 , C07C2603/74
摘要: A compound represented by the formula AF(—COF)n, provided that AF and n have the following meanings. AF: a fluorinated adamantane residue which is an n-valent group having an n number of hydrogen atoms removed from adamantane (provided that when n is at least 2, the removed hydrogen atoms are hydrogen atoms bonded to different carbon atoms), wherein at least one of the remaining hydrogen atoms is substituted by a fluorine atom, and the remaining hydrogen atoms may be substituted by a C1-6 alkyl group or fluoroalkyl group, and n: an integer of from 1 to 4, provided the when n is 1, AF has at least one hydrogen atom.
摘要翻译: 由式A -F( - COF)n N表示的化合物,条件是A和N具有下列含义。 氟化金刚烷残基,其是从金刚烷中除去n个氢原子的n价基团(条件是当n至少为2时,除去的氢原子是与氢原子键合的氢原子 不同的碳原子),其中剩余的氢原子中的至少一个被氟原子取代,剩余的氢原子可以被C 1-6烷基或氟代烷基取代,n :1〜4的整数,n为1时,A为至少1个氢原子。
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公开(公告)号:US06894187B2
公开(公告)日:2005-05-17
申请号:US10340634
申请日:2003-01-13
申请人: Takashi Okazoe , Kunio Watanabe , Shin Tatematsu , Masahiro Ito , Daisuke Shirakawa , Masao Iwaya , Hidekazu Okamoto
发明人: Takashi Okazoe , Kunio Watanabe , Shin Tatematsu , Masahiro Ito , Daisuke Shirakawa , Masao Iwaya , Hidekazu Okamoto
IPC分类号: C07C51/58 , C07C55/40 , C07C59/135 , C07C67/307 , C07C69/63 , C07C69/708 , C07C69/66 , C07C57/64
CPC分类号: C07C69/708 , C07C51/58 , C07C55/40 , C07C59/135 , C07C67/307 , C07C69/63
摘要: The present invention provides a method for obtaining a compound useful as a raw material for various fluororesins in high yield by a short process by using a starting material which is inexpensive and readily available.
摘要翻译: 本发明提供一种通过使用廉价且易于获得的起始材料,通过短时间获得用作各种氟树脂的原料的化合物的方法。
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公开(公告)号:US20050080291A1
公开(公告)日:2005-04-14
申请号:US11002463
申请日:2004-12-03
申请人: Marco Galimberti , Walter navarrini
发明人: Marco Galimberti , Walter navarrini
CPC分类号: C07C51/58 , C07C53/50 , C07C59/135
摘要: A process for preparing acylfluorides by reaction of carbonyl fluoride COF2 with compounds having general formula: T=CR1R2 (I) wherein: T is O or CF2 R1 and R2, equal or different, are F or a R(O)t radical, wherein R=linear or branched C1-C7 (per)fluoroalkyl, optionally containing one or more oxygen atoms, t is an integer equal to zero or 1; wherein a catalyst supported on porous compound is used, the catalyst being selected from: CsF, RbF, KF, AgF, each optionally in admixture with one or more of the others.
摘要翻译: 通过羰基氟化物COF 2与通式为T = CR 1 R 2(I)的化合物反应来制备酰氟的方法其中:T为O或CF 2 R 1和R 2等同或不同,为F或R(O)t基团,其中 R =任选含有一个或多个氧原子的直链或支链C 1 -C 7(全)氟代烷基,t是等于0或1的整数; 其中使用负载在多孔化合物上的催化剂,所述催化剂选自:CsF,RbF,KF,AgF,各自任选地与一种或多种其它物质混合。
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公开(公告)号:US3962326A
公开(公告)日:1976-06-08
申请号:US463826
申请日:1974-04-24
申请人: Gunther Semler , Georg Schaeffer , Karl Waldmann
发明人: Gunther Semler , Georg Schaeffer , Karl Waldmann
IPC分类号: C07C53/38 , C07B61/00 , C07C51/00 , C07C51/60 , C07C55/36 , C07C57/64 , C07C63/00 , C07C67/00 , C07C51/58
CPC分类号: C07C51/60
摘要: Process for preparing carboxylic acid chlorides by reaction of carboxylic acids or carboxylic anhydrides with phosgene at temperatures of from 0.degree. to 180.degree.C in the presence of a catalyst, wherein 0.01 to 10 weight percent, calculated on the carboxylic acid or the carboxylic anhydride, of trisubstituted phosphine oxides or trisubstituted phosphine sulfides or reaction products of these compounds with phosgene and/or acids or acid anhydrides or mixtures of these compounds are used as catalyst.
摘要翻译: 通过羧酸或羧酸酐与光气在0℃至180℃的温度下在催化剂存在下反应制备羧酸氯化物的方法,其中0.01至10%(重量)按羧酸或羧酸酐计算, 三取代膦氧化物或三取代膦硫化物或这些化合物与光气和/或酸或酸酐或这些化合物的混合物的反应产物用作催化剂。
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