公开(公告)号：US20120238948A1

公开(公告)日：2012-09-20

申请号：US13446253

申请日：2012-04-13

Applicant: Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC: A61M5/00

CPC classification number: A61M1/3679 ,  A61B5/6861 ,  A61F2/82 ,  A61F2002/068 ,  A61F2250/0096 ,  A61M37/00 ,  A61M2205/04 ,  A61M2230/20

Abstract: Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices and systems are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen.

Abstract translation: 本文描述了用于控制脊椎动物受试者的血液流体和/或淋巴液中的一种或多种靶细胞类型的水平的装置，系统和方法。 提供了设备和系统，其包括限定被配置用于流体流动的至少一个内腔的主体; 至少一个可控流阻挡至所述至少一个内腔; 一个或多个传感器被配置为检测脊椎动物对象的血液流体或淋巴液中的一种或多种靶细胞类型; 设置在所述至少一个内腔内的至少一个治疗区域; 设置在所述至少一个处理区域中的至少一个反应性组分; 以及与所述一个或多个传感器通信并与所述至少一个可控流动屏障连通至少一个内腔的至少一个控制器。

公开(公告)号：US20120238945A1

公开(公告)日：2012-09-20

申请号：US13446183

申请日：2012-04-13

Applicant: Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC: A61M37/00 ,  A61M5/168

CPC classification number: A61M1/3679 ,  A61B5/6861 ,  A61F2/82 ,  A61F2002/068 ,  A61F2250/0096 ,  A61M37/00 ,  A61M2205/04 ,  A61M2230/20

Abstract: Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices, systems, and methods are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen.

公开(公告)号：US20120238944A1

公开(公告)日：2012-09-20

申请号：US13446130

申请日：2012-04-13

Applicant: Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

Inventor： Roderick A. Hyde ,  Muriel Y. Ishikawa ,  Edward K.Y. Jung ,  Robert Langer ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, JR.

IPC: A61M37/00 ,  A61M5/168

CPC classification number: A61M1/3679 ,  A61B5/6861 ,  A61F2/82 ,  A61F2002/068 ,  A61F2250/0096 ,  A61M37/00 ,  A61M2205/04 ,  A61M2230/20

Abstract: Devices, systems, and methods are described herein for controlling the level of one or more target cell types in the blood fluid and/or lymph fluid of a vertebrate subject. Devices, systems, and methods are provided that include a body defining at least one lumen configured for fluid flow; at least one controllable flow barrier to the at least one lumen; one or more sensor configured to detect one or more target cell types in blood fluid or lymph fluid of a vertebrate subject; at least one treatment region disposed within the at least one lumen; at least one reactive component disposed in the at least one treatment region; and at least one controller in communication with the one or more sensor and in communication with the at least one controllable flow barrier to the at least one lumen.

Abstract translation: 本文描述了用于控制脊椎动物受试者的血液流体和/或淋巴液中的一种或多种靶细胞类型的水平的装置，系统和方法。 提供了设备，系统和方法，其包括限定被配置用于流体流动的至少一个内腔的主体; 至少一个可控流阻挡至所述至少一个内腔; 一个或多个传感器被配置为检测脊椎动物对象的血液流体或淋巴液中的一种或多种靶细胞类型; 设置在所述至少一个内腔内的至少一个治疗区域; 设置在所述至少一个处理区域中的至少一个反应性组分; 以及与所述一个或多个传感器通信并与所述至少一个可控流动屏障连通至少一个内腔的至少一个控制器。

公开(公告)号：US20120238837A1

公开(公告)日：2012-09-20

申请号：US13065267

申请日：2011-03-16

Applicant: Roderick A. Hyde ,  Sharon L. Wolda ,  Lowell L. Wood,, JR.

Inventor： Roderick A. Hyde ,  Sharon L. Wolda ,  Lowell L. Wood,, JR.

IPC: A61B5/1455 ,  A61B5/00

Abstract: Systems, devices, methods, and compositions are described for providing real-time monitoring of cerebrospinal fluid for markers of progressive conditions.

公开(公告)号：US08265945B2

公开(公告)日：2012-09-11

申请号：US12655250

申请日：2009-12-23

Applicant: Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

Inventor： Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

IPC: G06Q10/00

CPC classification number: G06Q10/10 ,  G06F19/00 ,  G06Q50/24

Abstract: A computationally implemented method includes, but is not limited to: determining whether a plurality of end users deviated from compliantly executing a template designed to facilitate the plurality of end users in achieving one or more target outcomes when one or more emulatable aspects included in the template are emulated by the plurality of end users, the one or more emulatable aspects being based on one or more relevant reported aspects of one or more source users that were deemed to have been relevant to achieving the one or more target outcomes; and modifying the template based, at least in part, on determining that the plurality of end users deviated from compliantly executing the template In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

公开(公告)号：US08265944B2

公开(公告)日：2012-09-11

申请号：US12655075

申请日：2009-12-21

Applicant: Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K.Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

Inventor： Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K.Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

IPC: G06Q10/00

CPC classification number: G06Q10/10 ,  G06Q50/01

Abstract: A computationally implemented method includes, but is not limited to: detecting deviation from a compliant execution of a template by an end user, the template designed to facilitate the end user to achieve one or more target outcomes when one or more emulatable aspects included in the template are emulated, the one or more emulatable aspects being based on one or more relevant reported aspects of one or more source users that are relevant to achieving the one or more target outcomes; and executing one or more actions in response to the detecting of the deviation In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

Abstract translation: 计算实现的方法包括但不限于：检测最终用户对模板的顺从执行的偏差，该模板被设计为当最终用户在包含在一个或多个可模仿方面中的一个或多个可塑化方面时实现一个或多个目标结果 仿真模板，一个或多个可锻炼的方面基于与实现一个或多个目标结果相关的一个或多个源用户的一个或多个相关报告的方面; 并且响应于偏差的检测而执行一个或多个动作除了上述之外，在构成本公开的一部分的权利要求，附图和文本中描述了其它方法方面。

公开(公告)号：US08265943B2

公开(公告)日：2012-09-11

申请号：US12584489

申请日：2009-09-03

Applicant: Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

Inventor： Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

IPC: G06Q10/00

CPC classification number: G06Q10/10

Abstract: A computationally implemented method includes, but is not limited to: receiving a request for a personalized plan designed to facilitate an end user to achieve one or more target outcomes when one or more emulatable aspects indicated by the personalized plan are emulated, the request identifying at least a source user; acquiring source user data indicating a plurality of reported aspects associated with at least the source user in response to receiving the request; and developing the personalized plan by at least determining which of the plurality of reported aspects associated with the source user are relevant to the achievement of the one or more target outcomes. In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

Abstract translation: 计算实现的方法包括但不限于：接收针对个性化计划的请求，该个性化计划被设计为当模拟由个性化计划指示的一个或多个可仿效方面时最终用户实现一个或多个目标结果，该请求标识在 至少一个源用户; 响应于接收到所述请求，获取指示与至少所述源用户相关联的多个报告方面的源用户数据; 以及通过至少确定与所述源用户相关联的所述多个报告的方面中的哪一个与所述一个或多个目标结果的实现相关来开发所述个性化计划。 除了上述之外，在权利要求，附图和形成本公开的一部分的文本中描述了其它方法方面。

公开(公告)号：US08260625B2

公开(公告)日：2012-09-04

申请号：US12653386

申请日：2009-12-11

Applicant: Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

Inventor： Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

IPC: G06Q10/00

CPC classification number: G06Q99/00 ,  G06Q10/10

Abstract: A computationally implemented method includes, but is not limited to: receiving one or more requests indicating at least one or more target outcomes of one or more particular templates, the one or more particular templates designed to facilitate one or more end users to achieve the one or more target outcomes when one or more emulatable aspects included in the one or more particular templates are emulated; and providing from a plurality of templates the one or more particular templates, the providing being based at least on the one or more particular templates' association with the one or more target outcomes, the one or more particular templates developed based on one or more reported aspects of one or more source users In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

公开(公告)号：US08256233B2

公开(公告)日：2012-09-04

申请号：US12590029

申请日：2009-10-30

Applicant: Edward S. Boyden ,  Daniel B. Cook ,  Roderick A. Hyde ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

Inventor： Edward S. Boyden ,  Daniel B. Cook ,  Roderick A. Hyde ,  Eric C. Leuthardt ,  Nathan P. Myhrvold ,  Elizabeth A. Sweeney ,  Lowell L. Wood, Jr.

IPC: F25C1/00

CPC classification number: G06F19/00 ,  A61K9/0019 ,  A61K9/0021 ,  A61K9/007 ,  A61K9/08 ,  A61K9/1611 ,  A61K9/1617 ,  A61K9/1641 ,  A61K9/1664 ,  A61K9/1688 ,  A61K9/19 ,  A61K31/00 ,  A61K31/337 ,  A61K31/70 ,  A61K31/7008 ,  A61K31/7088 ,  A61K33/00 ,  A61K38/38 ,  A61K38/4833 ,  A61K38/4886 ,  A61K39/00 ,  A61K41/0004 ,  A61K45/06 ,  A61K51/1244 ,  B33Y80/00 ,  A61K2300/00

Abstract: Certain embodiments disclosed herein relate to compositions, methods, devices, systems, and products regarding frozen particles. In certain embodiments, the frozen particles include materials at low temperatures. In certain embodiments, the frozen particles provide vehicles for delivery of particular agents. In certain embodiments, the frozen particles are administered to at least one substrate.

Abstract translation: 本文公开的某些实施方案涉及关于冷冻颗粒的组合物，方法，装置，系统和产品。 在某些实施方案中，冷冻颗粒包括低温下的材料。 在某些实施方案中，冷冻颗粒提供用于递送特定试剂的载体。 在某些实施方案中，将冷冻颗粒施用于至少一种底物。

公开(公告)号：US08234123B2

公开(公告)日：2012-07-31

申请号：US12590600

申请日：2009-11-10

Applicant: Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

Inventor： Shawn P. Firminger ,  Jason Garms ,  Roderick A. Hyde ,  Edward K. Y. Jung ,  Chris D. Karkanias ,  Eric C. Leuthardt ,  Royce A. Levien ,  Richard T. Lord ,  Robert W. Lord ,  Mark A. Malamud ,  John D. Rinaldo, Jr. ,  Clarence T. Tegreene ,  Kristin M. Tolle ,  Lowell L. Wood, Jr.

IPC: G06Q10/00

CPC classification number: G06Q10/06 ,  G06Q50/01

Abstract: A computationally implemented method includes, but is not limited to: identifying one or more relevant reported aspects associated with one or more source users that are relevant to achieving one or more target outcomes, the identifying of the one or more relevant reported aspects being based, at least in part, on the one or more relevant reported aspects' relevancy with respect to the one or more target outcomes; and developing one or more personalized plans designed to facilitate an end user to achieve the one or more target outcomes when one or more emulatable aspects indicated by the one or more personalized plans are emulated, the development of the one or more personalized plans being based, at least in part, on the identifying. In addition to the foregoing, other method aspects are described in the claims, drawings, and text forming a part of the present disclosure.

Abstract translation: 计算实现的方法包括但不限于：识别与实现一个或多个目标结果相关的一个或多个源用户相关联的一个或多个相关报告方面，基于所述一个或多个相关报告方面的识别， 至少部分地关于一个或多个相关报告方面对于一个或多个目标结果的相关性; 以及开发一个或多个个性化计划，所述个性化计划被设计成在仿真由所述一个或多个个性化计划指示的一个或多个可塑化方面时促成最终用户实现所述一个或多个目标结果，基于所述一个或多个个性化计划的开发， 至少部分是鉴定。 除了上述之外，在权利要求，附图和形成本公开的一部分的文本中描述了其它方法方面。