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    IMPLANTABLE ENDOLUMINAL PROSTHESIS
    2.
    发明申请
    IMPLANTABLE ENDOLUMINAL PROSTHESIS 审中-公开

    公开(公告)号：US20180325708A1

    公开(公告)日：2018-11-15

    申请号：US15775332

    申请日：2016-11-10

    申请人： Noureddine FRID ,  Cardiatis S.A.

    发明人： Noureddine Frid

    IPC分类号： A61F2/90

    CPC分类号： A61F2/90 ,  A61F2002/068 ,  A61F2002/823 ,  A61F2210/0014 ,  A61F2210/0076 ,  A61F2230/0069

    摘要： The present invention refers to an implantable endoluminal prosthesis for use in the treatment of aneurysm involving branches having a multilayer configuration, comprising at least one self-expandable braided framework extending along an axis able to expand from a radially compressed state in a delivery configuration to a radially expanded state; the self-expandable braided framework being formed with at most 196 wires having a given wire diameter (Ø21); this self-expandable braided framework devoid of any impermeable cover layer, comprising a plurality of layers of wires made of biocompatible material; and forming a wall of the endoluminal prosthesis; each layer forming a mesh; the meshes forming a lattice with a plurality of wires of said layers; the meshes being interlocked, the wires being integrated in the mesh of at least one of the adjacent layers; the self-expandable braided framework comprising a lumen in a cylindrical form with a circular cross-section and a constant diameter; characterized in that, in radially expanded state, a ratio (T1/Ø21) of thickness (T1) of a wall of the implantable endoluminal prosthesis in radially expanded state to the diameter (Ø21) of wire (21) being greater than 3.0; and the surface coverage ratio (SCR) of said braided framework is at least 30% and at most 50%.

    BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME
    3.
    发明申请
    BIOMIMETIC VASCULAR NETWORK AND DEVICES USING THE SAME 审中-公开

    公开(公告)号：US20180256312A1

    公开(公告)日：2018-09-13

    申请号：US15800687

    申请日：2017-11-01

    申请人： The General Hospital Corporation ,  The Charles Stark Draper Laboratory

    发明人： David M. Hoganson ,  Howard I. Pryor ,  Ira Spool ,  Joseph P. Vacanti ,  Jeffrey T. Borenstein

    IPC分类号： A61F2/06 ,  A61F2/04 ,  A61F2/02 ,  G01N33/50

    CPC分类号： A61F2/062 ,  A61F2/022 ,  A61F2/04 ,  A61F2/06 ,  A61F2002/068 ,  G01N33/5008

    摘要： The invention provides method of fabricating a scaffold comprising a fluidic network, including the steps of: (a) generating an initial vascular layer for enclosing the chamber and providing fluid to the cells, the initial vascular layer having a network of channels for fluid; (b) translating the initial vascular layer into a model for fluid dynamics analysis; (c) analyzing the initial vascular layer based on desired parameters selected from the group consisting of a characteristic of a specific fluid, an input pressure, an output pressure, an overall flow rate and combinations thereof to determine sheer stress and velocity within the network of channels; (d) measuring the sheer stress and the velocity and comparing the obtained values to predetermined values; (e) determining if either of the shear stress or the velocity are greater than or less than the predetermined values, and (f) optionally modifying the initial vascular layer and repeating steps (b)-(e). The invention also provides compositions comprising a vascular layer for use in tissue lamina as well as a medical devices having a vascular layer and kits.