公开(公告)号：US20130211071A1

公开(公告)日：2013-08-15

申请号：US13825799

申请日：2011-09-23

Applicant: William Rusty Sutterlin ,  Mark G. Tegen ,  William W. Berry

Inventor： William Rusty Sutterlin ,  Mark G. Tegen ,  William W. Berry

IPC: C07D223/10 ,  C07D223/12

CPC classification number: C07D223/10 ,  C07D201/08 ,  C07D223/12

Abstract: The present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol under Super Critical Fluid conditions. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-ε-caprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

Abstract translation: 本发明可以涉及一种合成α-氨基-ε-己内酰胺的方法。 该方法可以包括在超临界流体条件下在包含醇的溶剂中加热L-赖氨酸的盐。 该方法可以包括在包含醇的溶剂中加热L-赖氨酸的盐并使反应产物脱氨。 在各种实施方案中，本发明可以包括将生物质转化成尼龙6的方法。该方法可以包括在包含醇的溶剂中加热L-赖氨酸以产生α-氨基 - ε-己内酰胺，脱氨以产生ε-己内酰胺并聚合成尼龙 6，其中L-赖氨酸衍生自生物质。 在其它实施方案中，本发明可以包括制备尼龙6的方法。该方法可以包括合成ε-己内酰胺然后聚合，其中ε-己内酰胺衍生自L-赖氨酸。

公开(公告)号：US20130030146A1

公开(公告)日：2013-01-31

申请号：US13518647

申请日：2010-12-22

Applicant: Rudolf Philippus Maria Guit ,  Thomas Van Der Does ,  Lourina Madeleine Raamsdonk

Inventor： Rudolf Philippus Maria Guit ,  Thomas Van Der Does ,  Lourina Madeleine Raamsdonk

IPC: C07D223/10 ,  C08G69/04

CPC classification number: C07D201/08 ,  C07D201/16 ,  C07D223/10 ,  C08G69/16

Abstract: The invention relates to a method for preparing caprolactam comprising recovering a mixture containing 6-aminocaproic acid, from a culture medium comprising biomass, and thereafter cyclising the 6-aminocaproic acid in the presence of superheated steam, thereby forming caprolactam, wherein the weight to weight ratio carbohydrate to 6-aminocaproic acid in said mixture is 0.03 or less.

Abstract translation: 本发明涉及一种制备己内酰胺的方法，包括从含有生物质的培养基中回收含有6-氨基己酸的混合物，然后在过热蒸汽存在下环化6-氨基己酸，从而形成己内酰胺，其中重量 所述混合物中碳水化合物与6-氨基己酸的比例为0.03以下。

公开(公告)号：US08283466B2

公开(公告)日：2012-10-09

申请号：US12527848

申请日：2008-02-20

Applicant: John W. Frost

Inventor： John W. Frost

IPC: C07D201/02 ,  C07D201/08

CPC classification number: C07D201/00 ,  C07D201/02 ,  C07D201/08 ,  Y02P20/52

Abstract: Catalytic processes for preparing caprolactam, pipecolinic acid, and their derivatives, from lysine or alpha-amino-epsilon-caprolactam starting materials, and products produced thereby. A process for preparing caprolactam or a derivative thereof, the process comprising contacting a reactant comprising lysine or alpha aminocaprolactam with a catalyst and a gas comprising hydrogen gas, in the presence of a solvent. The catalyst may be provided on a support material, such as a transition metal.

Abstract translation: 从赖氨酸或α-氨基-ε-己内酰胺起始原料制备己内酰胺，哌可啶酸及其衍生物的催化方法，以及由此产生的产物。 一种制备己内酰胺或其衍生物的方法，该方法包括在溶剂存在下使包含赖氨酸或α-氨基己内酰胺的反应物与催化剂和包含氢气的气体接触。 催化剂可以设置在载体材料如过渡金属上。

公开(公告)号：US20120142886A1

公开(公告)日：2012-06-07

申请号：US13175450

申请日：2011-07-01

Applicant: John W. Frost

Inventor： John W. Frost

IPC: C08G69/16 ,  C07D223/10 ,  C07D223/12

CPC classification number: C07D223/12 ,  C07D201/08

Abstract: In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-εcaprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

Abstract translation: 在各种实施方案中，本发明可以涉及α-氨基 - 己内酰胺的合成方法。 该方法可以包括在包含醇的溶剂中加热L-赖氨酸的盐。 在其它实施方案中，本发明可涉及合成ε-己内酰胺的方法。 该方法可以包括在包含醇的溶剂中加热L-赖氨酸的盐并使反应产物脱氨。 在各种实施方案中，本发明可以包括将生物质转化成尼龙6的方法。该方法可以包括在包含醇的溶剂中加热L-赖氨酸以产生α-氨基 - 己内酰胺，脱氨以产生ε-己内酰胺并聚合 进入尼龙6，其中L-赖氨酸衍生自生物质。 在其它实施方案中，本发明可以包括制备尼龙6的方法。该方法可包括合成ε-己内酰胺然后聚合，其中ε-己内酰胺衍生自L-赖氨酸。

公开(公告)号：US20110257358A1

公开(公告)日：2011-10-20

申请号：US13123571

申请日：2009-10-09

Applicant: Daniel Mink ,  Rudolf Philippus Maria Guit ,  Monika Muller ,  Petronella Catharina Raemakers-Franken

Inventor： Daniel Mink ,  Rudolf Philippus Maria Guit ,  Monika Muller ,  Petronella Catharina Raemakers-Franken

IPC: C08G69/16 ,  C12P17/10 ,  C12N1/00 ,  C07D201/08

CPC classification number: C07D201/08 ,  C07D223/10 ,  C12P17/10

Abstract: The invention relates to a method for preparing ε-caprolactam comprising deacylating N-acyl-6-aminocaproic acid and forming ε-caprolactam. The deacylation may be carried out chemically or biocatalytically. The invention further relates to a host cell, comprising a recombinant vector comprising a nucleic acid sequence encoding an enzyme capable of catalysing the formation of 6-aminocaproic acid from N-acyl-6-aminocaproic acid.

Abstract translation: 本发明涉及一种制备ε-己内酰胺的方法，其包括使N-酰基-6-氨基己酸脱酰并形成ε-己内酰胺。 脱酰基化可以化学或生物催化进行。 本发明还涉及宿主细胞，其包含重组载体，其包含编码能够从N-酰基-6-氨基己酸催化形成6-氨基己酸的酶的核酸序列。

公开(公告)号：US20110171699A1

公开(公告)日：2011-07-14

申请号：US12921733

申请日：2009-03-11

Applicant: Petronella Catharina Raemakers-Franken ,  Martin Schurmann ,  Axel Christoph Trefzer ,  Stefaan Marie Andre De Wildeman

Inventor： Petronella Catharina Raemakers-Franken ,  Martin Schurmann ,  Axel Christoph Trefzer ,  Stefaan Marie Andre De Wildeman

IPC: C12P13/00 ,  C07D201/08 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C07H21/00 ,  C12N1/00

CPC classification number: C12P13/001 ,  C07C227/06 ,  C07D201/08 ,  C07D223/10 ,  C12P13/005 ,  C12P13/02 ,  C07C229/08

Abstract: The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.

Abstract translation: 本发明涉及使用生物催化剂制备6-氨基己酸（以下也称为“6-ACA”）的方法。 本发明还涉及通过环化这种6-ACA制备ε-己内酰胺（以下称为“己内酰胺”）的方法。 本发明还涉及可用于制备6-ACA或己内酰胺的宿主细胞，微生物或多核苷酸。

公开(公告)号：US07491859B2

公开(公告)日：2009-02-17

申请号：US11299101

申请日：2005-12-09

Applicant: Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

Inventor： Eit Drent ,  Michael Rolf Eberhard ,  Paul Gerald Pringle ,  Renata Helena van der Made

IPC: B01J31/18 ,  B01J31/22 ,  C07C2/32 ,  C07C2/36

CPC classification number: B01J31/248 ,  B01J23/44 ,  B01J31/1895 ,  B01J31/24 ,  B01J2231/20 ,  B01J2531/80 ,  B01J2531/824 ,  C07C2/36 ,  C07C2/406 ,  C07C41/06 ,  C07C253/30 ,  C07C2531/24 ,  C07C2531/28 ,  C07D201/08 ,  C07F9/5027 ,  C07F9/65683 ,  C07C255/19 ,  C07C11/12 ,  C07C43/15

Abstract: Process for the telomerization of a conjugated diene,wherein the conjugated diene is reacted with a compound containing an active hydrogen atom and having a formula R′—H in the presence of a telomerization catalyst based on:(a) a source of group VIII metal,(b) a bidentate ligandwherein the bidentate ligand has the general formula I R1R2M1-R-M2R3R4  (I) wherein M1 and M2 are independently P, As or Sb; R1, R2, R3 and R4 independently represent a monovalent aliphatic group; or R1, R2 and M1 together and/or R3, R4 and M2 together independently represent an optionally substituted aliphatic cyclic group with at least 5 ring atoms, of which one is the M1 or M2 atom, respectively; R represents a bivalent organic bridging group; and novel bidentate diphosphines which can be used in this process.

Abstract translation: 共轭二烯的调聚方法，其中在调聚催化剂的存在下，共轭二烯与含有活性氢原子的化合物反应并具有式R'-H，其基于：（a）VIII族金属源 ，（b）双齿配体，其中二齿配体具有通式I <βin-line-formula description =“In-line Formulas”end =“lead”→> R1R2M1-R-M2R3R4（I） line-formula description =“In-line Formulas”end =“tail”？>其中M1和M2独立地为P，As或Sb; R1，R2，R3和R4独立地表示一价脂族基团; 或R 1，R 2和M 1一起和/或R 3，R 4和M 2一起独立地表示任选取代的具有至少5个环原子的脂族环基，其中一个是分别为M1或M2原子; R表示二价有机桥基; 和可用于该方法的新型二齿二膦。

公开(公告)号：US20090005532A1

公开(公告)日：2009-01-01

申请号：US12147256

申请日：2008-06-26

Applicant: John W. Frost

Inventor： John W. Frost

IPC: C08G69/16

CPC classification number: C07D223/12 ,  C07D201/08

Abstract: In various embodiments, the present invention can involve a method of synthesizing α-amino-ε-caprolactam. The method can comprise heating a salt of L-lysine in a solvent comprising an alcohol. In other embodiments, the present invention can involve methods for synthesizing ε-caprolactam. The methods can comprise heating a salt of L-lysine in a solvent comprising an alcohol and deaminating the reaction product. In various embodiments, the invention can include methods of converting biomass into nylon 6. The methods can comprise heating L-lysine in a solvent comprising an alcohol to produce α-amino-ε-caprolactam, deaminating to produce ε-caprolactam and polymerizing into nylon 6, wherein the L-lysine is derived from the biomass. In other embodiments, the present invention can include methods of making nylon 6. The methods can comprise synthesizing ε-caprolactam and then polymerizing, wherein the ε-caprolactam is derived from L-lysine.

Abstract translation: 在各种实施方案中，本发明可涉及合成α-氨基-ε-己内酰胺的方法。 该方法可以包括在包含醇的溶剂中加热L-赖氨酸的盐。 在其它实施方案中，本发明可涉及合成ε-己内酰胺的方法。 该方法可以包括在包含醇的溶剂中加热L-赖氨酸的盐并使反应产物脱氨。 在各种实施方案中，本发明可以包括将生物质转化成尼龙6的方法。该方法可以包括在包含醇的溶剂中加热L-赖氨酸以产生α-氨基 - ε-己内酰胺，脱氨以产生ε-己内酰胺并聚合成尼龙 6，其中所述L-赖氨酸衍生自所述生物质。 在其它实施方案中，本发明可以包括制备尼龙6的方法。该方法可以包括合成ε-己内酰胺然后聚合，其中ε-己内酰胺衍生自L-赖氨酸。

公开(公告)号：US07384518B2

公开(公告)日：2008-06-10

申请号：US10296512

申请日：2001-05-28

Applicant: Daniel Amoros ,  Philippe Leconte ,  Pierre Coqueret

Inventor： Daniel Amoros ,  Philippe Leconte ,  Pierre Coqueret

IPC: B01D3/34 ,  C07D201/08 ,  C07D201/16

CPC classification number: C07D201/16 ,  C07D201/08 ,  Y10S203/90

Abstract: A method and a plant are disclosed for purifying lactams, particularly lactams obtained by cyclizing hydrolysis of aminonitrile. The purification of ε-caprolactam obtained by cyclizing hydrolysis of aminocapronitrile is described which includes eliminating the ammonia from the reaction medium of the hydrolysis, then recovering the lactam from said medium in purified form. The recovery is carried out by performing at least a distillation of the lactam in the presence of a base producing optionally a fronts fraction comprising compounds more volatile than the lactam, a fraction comprising the lactam to be recovered to the degree of desired purity and a distillation tails comprising the lactam and compounds less volatile than the lactam. The distillation tails are treated by various processes such as evaporation in thin layers to recover the major part of the caprolactam and recycling the latter in the purification process. The method and plant enables a high rate of recovery of the caprolactam contained in the hydrolysis medium, while observing required criteria of purity.

Abstract translation: 公开了一种用于纯化内酰胺，特别是通过环化氨基腈水解获得的内酰胺的方法和设备。 描述了通过环化氨基己腈水解获得的ε-己内酰胺的纯化，其包括从水解反应介质中除去氨，然后以纯化形式从所述介质中回收内酰胺。 回收是通过在碱的存在下至少进行内消旋而进行的，所述碱生产任选地含有比内酰胺更易挥发的化合物的前列馏分，包含待回收的内酰胺至所需纯度的馏分和蒸馏 尾部包含内酰胺和化合物比内酰胺更不易挥发。 蒸馏尾部通过各种方法处理，例如在薄层中蒸发以回收大部分己内酰胺并在纯化过程中回收己内酰胺。 该方法和设备能够在观察所需的纯度标准的同时使包含在水解介质中的己内酰胺的回收率高。

公开(公告)号：US07238804B2

公开(公告)日：2007-07-03

申请号：US11314586

申请日：2005-12-21

Applicant: Martyn Poliakoff ,  Paul Hamley ,  Chong Yan ,  Eduardo Garcia-Verdugo Cepeda ,  Graham Robert Aird ,  Alexander Stuart Coote ,  Ian Pearson ,  William Barry Thomas

Inventor： Martyn Poliakoff ,  Paul Hamley ,  Chong Yan ,  Eduardo Garcia-Verdugo Cepeda ,  Graham Robert Aird ,  Alexander Stuart Coote ,  Ian Pearson ,  William Barry Thomas

IPC: C07D201/08

CPC classification number: C07D201/08

Abstract: A process for the manufacture of a lactam from an amino alkane nitrile and/or its hydrolysis derivatives, comprising reacting a solution comprising at least about 5% by weight amino alkane nitrile in water at a temperature of greater than or equal to about 350° C. and at a pressure of greater than about 250 bar. Optionally, a dilute acid may be added as a catalyst.

Abstract translation: 一种用于从氨基烷腈和/或其水解衍生物制备内酰胺的方法，包括使包含至少约5重量％氨基烷腈的溶液在大约或等于约350℃的温度下在水中反应 并且在大于约250巴的压力下。 任选地，可以加入稀酸作为催化剂。