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1.发明申请PREPARATION OF EPSILON-CAPROLACTAM FROM (Z)-6,7-DIHYDRO-1H-AZEPIN-2(5H)-ONE 审中-公开（Z）-6,7-二氢-1H-亚苄基-2（5H） - 酮的EPSILON-CAPROLACTAM的制备公开(公告)号：US20110183386A1
公开(公告)日：2011-07-28
申请号：US12991605
申请日：2009-05-20
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
CPC分类号： C12P17/10
摘要： The invention relates to a method for preparing ε-caprolactam comprising reducing the carbon-carbon double bond of (Z)-6,7-dihydro-1H-azepin-2(5H)-one, wherein the reduction is catalysed by a biocatalyst. The invention further relates to a novel host cell comprising a biocatalyst capable of catalysing said reduction and to a novel polynucleotide encoding a biocatalyst capable of catalysing said reduction.
摘要翻译： 本发明涉及一种制备ε-己内酰胺的方法，包括还原（Z）-6,7-二氢-1H-吖庚因-2（5H） - 酮的碳 - 碳双键，其中还原是由生物催化剂 。 本发明还涉及包含能够催化所述还原的生物催化剂的新型宿主细胞和编码能够催化所述还原的生物催化剂的新型多核苷酸。
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公开(公告)号：US20110091944A1
公开(公告)日：2011-04-21
申请号：US12921547
申请日：2009-03-11
申请人： Liang Wu , Stefaan Marie Andre De Wildeman , Marco Alexander Van Den Berg , Axel Christoph Trefzer
发明人： Liang Wu , Stefaan Marie Andre De Wildeman , Marco Alexander Van Den Berg , Axel Christoph Trefzer
摘要： The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.
摘要翻译： 本发明涉及一种制备己二酸酯或硫酯的方法。 本发明还涉及从所述酯或硫酯制备己二酸的方法。 此外，本发明提供了许多用于制备所述酯或硫酯的中间体的方法。 本发明还涉及制备6-氨基己酸（6-ACA）的方法，5-甲酰戊酸（5-FVA）的制备方法和己内酰胺的制备方法。 此外，本发明涉及用于根据本发明的方法的宿主细胞。
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3.发明申请ALPHA-SUBSTITUTED A,B-UNSATURATED E- OR Z-ALDEHYDES, USE THEREOF, AND PROCESSES FOR THEIR PREPARATION A,B 失效ALPHA取代的A，B-不饱和的E-或Z-醛，其用途及其制备方法A，B公开(公告)号：US20100234630A1
公开(公告)日：2010-09-16
申请号：US12668236
申请日：2008-07-11
申请人： Gerhard Steinbauer , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Andreas Hendrikus Maria De Vries
发明人： Gerhard Steinbauer , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Andreas Hendrikus Maria De Vries
IPC分类号： C07C47/277 , C07F7/02 , C07C309/01 , C07C45/00 , C07C47/27
CPC分类号： C07C47/277 , C07C37/002 , C07C37/62 , C07C41/22 , C07C41/26 , C07C45/516 , C07C45/562 , C07C45/62 , C07C45/63 , C07C45/72 , C07C45/74 , C07C47/27 , C07C69/78 , C07C309/66 , C07C309/73 , C12P7/24 , C07C43/23 , C07C43/225 , C07C39/373 , C07C39/24
摘要： This invention relates to novel alpha-substituted α,β-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.
摘要翻译： 本发明涉及式（I）的新型α-取代的α，β-不饱和的E-或Z-醛或其异构体混合物，其中R 1和R 2可以相同或不同并且各自为H或烃， 其中烃可以具有一个或多个杂原子，并且R 3和R 4可以相同或不同，并且各自为烃，其中烃可以具有一个或多个杂原子，R 5可以相同或不同，为H或烃， 其中烃可以具有一个或多个杂原子，其用途及其制备方法。 本发明还涉及药物的其它中间体的制备和药物的制备。
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4.发明申请ALPHA-SUBSTITUTED ALPHA, BETA-UNSATURATED E- OR Z-ALDEHYDES, USE THEREOF, AND PROCESSES FOR THEIR PREPARATION ALPHA, BETA 审中-公开ALPHA替代的阿尔法，β-不饱和的E-或Z-阿尔德，其使用及其制备方法ALPHA，BETA公开(公告)号：US20110301365A1
公开(公告)日：2011-12-08
申请号：US13205498
申请日：2011-08-08
申请人： Gerhard STEINBAUER , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
发明人： Gerhard STEINBAUER , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
IPC分类号： C07D307/02 , C07C237/02
CPC分类号： C07C47/277 , C07C37/002 , C07C37/62 , C07C41/22 , C07C41/26 , C07C45/516 , C07C45/562 , C07C45/62 , C07C45/63 , C07C45/72 , C07C45/74 , C07C47/27 , C07C69/78 , C07C309/66 , C07C309/73 , C12P7/24 , C07C43/23 , C07C43/225 , C07C39/373 , C07C39/24
摘要： This invention relates to novel alpha-substituted α,β-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.
摘要翻译： 本发明涉及下式的新型α-取代的α，β-不饱和的E-或Z-醛或其异构体混合物，其中R 1和R 2可以相同或不同并且各自为H或烃，其中 烃可以具有一个或多个杂原子，R 3和R 4可以相同或不同，并且各自为烃，其中烃可以具有一个或多个杂原子，R 5可以相同或不同，为H或烃，其中 烃可以具有一个或多个杂原子，以及其制备方法。 本发明还涉及药物的其它中间体的制备和药物的制备。
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公开(公告)号：US20120156737A1
公开(公告)日：2012-06-21
申请号：US13255161
申请日：2010-03-11
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
CPC分类号： C12P7/50 , C12N9/0008 , C12N9/1025 , C12N9/88 , C12P7/44 , C12P13/005 , C12P13/02 , C12P17/10
摘要： The invention relates to a method for preparing alpha-ketopimelic acid, comprising converting alpha-ketoglutaric acid into alpha-ketoadipic acid and converting alpha-ketoadipic acid into alpha-ketopimelic acid, wherein at least one of these conversions is carried out using a heterologous biocatalyst. The invention further relates to a heterologous cell, comprising one or more heterologous nucleic acid sequences encoding one or more heterologous enzymes capable of catalysing at least one reaction step in the preparation of alpha-ketopimelic acid from alpha-ketoglutaric acid.
摘要翻译： 本发明涉及一种制备α-酮戊二酸的方法，包括将α-酮戊二酸转化成α-酮己二酸，并将α-酮己二酸转化成α-酮戊二酸，其中这些转化中的至少一种是使用异源生物催化剂 。 本发明还涉及异源细胞，其包含一种或多种编码一种或多种异源酶的异源核酸序列，所述异源酶能够催化从α-酮戊二酸制备α-酮戊二酸的至少一个反应步骤。
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公开(公告)号：US20140134681A1
公开(公告)日：2014-05-15
申请号：US14105705
申请日：2013-12-13
申请人： Petronella Catharina RAEMAKERS-FRANKEN , Martin SCHURMANN , Axel Christoph TREFZER , Stefaan Marie Andre DE WILDEMAN
发明人： Petronella Catharina RAEMAKERS-FRANKEN , Martin SCHURMANN , Axel Christoph TREFZER , Stefaan Marie Andre DE WILDEMAN
IPC分类号： C12P13/00 , C07D201/08
CPC分类号： C12P13/001 , C07C227/06 , C07D201/08 , C07D223/10 , C12P13/005 , C12P13/02 , C07C229/08
摘要： The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.
摘要翻译： 本发明涉及使用生物催化剂制备6-氨基己酸（以下也称为“6-ACA”）的方法。 本发明还涉及通过环化这种6-ACA制备ε-己内酰胺（以下称为“己内酰胺”）的方法。 本发明还涉及可用于制备6-ACA或己内酰胺的宿主细胞，微生物或多核苷酸。
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公开(公告)号：US08673599B2
公开(公告)日：2014-03-18
申请号：US12921733
申请日：2009-03-11
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
IPC分类号： C12P13/00 , C12N1/21 , C12N1/15 , C07C227/06 , C07D223/10
CPC分类号： C12P13/001 , C07C227/06 , C07D201/08 , C07D223/10 , C12P13/005 , C12P13/02 , C07C229/08
摘要： The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.
摘要翻译： 本发明涉及使用生物催化剂制备6-氨基己酸（以下也称为“6-ACA”）的方法。 本发明还涉及通过环化这种6-ACA制备ε-己内酰胺（以下称为“己内酰胺”）的方法。 本发明还涉及可用于制备6-ACA或己内酰胺的宿主细胞，微生物或多核苷酸。
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8.发明授权Alpha-substituted α,β-unsaturated E- or Z-aldehydes, use thereof, and processes for their preparation α,β 失效α-取代的α，β-不饱和的E-或Z-醛，其用途及其制备方法α，bgr;公开(公告)号：US08088955B2
公开(公告)日：2012-01-03
申请号：US12668236
申请日：2008-07-11
申请人： Gerhard Steinbauer , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
发明人： Gerhard Steinbauer , Martina Kotthaus , Klaus Edegger , Stefaan Marie Andre De Wildeman , Henricus Martinus Maria Gerardus Straatman , Anna Maria Cornelia Francisca Castelijns , Andreas Hendrikus Maria De Vries
IPC分类号： C07C47/27 , C07C45/00 , C07C309/01 , C07F7/02
CPC分类号： C07C47/277 , C07C37/002 , C07C37/62 , C07C41/22 , C07C41/26 , C07C45/516 , C07C45/562 , C07C45/62 , C07C45/63 , C07C45/72 , C07C45/74 , C07C47/27 , C07C69/78 , C07C309/66 , C07C309/73 , C12P7/24 , C07C43/23 , C07C43/225 , C07C39/373 , C07C39/24
摘要： This invention relates to novel alpha-substituted α,β-unsaturated E- or Z-aldehydes, or isomer mixture thereof, of the formula (I) in which R1 and R2 may be identical or different and are each H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms and R3 and R4 may be identical or different and are each a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, and R5 may be identical or different and is H or a hydrocarbon, in which the hydrocarbon may have one or more heteroatoms, to the use thereof, and to processes for their preparation. The invention further relates to the preparation of further intermediates for pharmaceuticals and to the preparation of the pharmaceuticals.
摘要翻译： 本发明涉及式（I）的新型α-取代的α，β-不饱和的E-或Z-醛或其异构体混合物，其中R 1和R 2可以相同或不同并且各自为H或烃， 其中烃可以具有一个或多个杂原子，并且R 3和R 4可以相同或不同，并且各自为烃，其中烃可以具有一个或多个杂原子，R 5可以相同或不同，为H或烃， 其中烃可以具有一个或多个杂原子，其用途及其制备方法。 本发明还涉及药物的其它中间体的制备和药物的制备。
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公开(公告)号：US20110171699A1
公开(公告)日：2011-07-14
申请号：US12921733
申请日：2009-03-11
申请人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
发明人： Petronella Catharina Raemakers-Franken , Martin Schurmann , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman
CPC分类号： C12P13/001 , C07C227/06 , C07D201/08 , C07D223/10 , C12P13/005 , C12P13/02 , C07C229/08
摘要： The invention relates to a method for preparing 6-aminocaproic acid (hereinafter also referred to as ‘6-ACA’) using a biocatalyst. The invention further relates to a method for preparing e-caprolactam (hereafter referred to as ‘caprolactam’) by cyclising such 6-ACA. The invention further relates to a host cell, a micro-organism, or a polynucleotide which may be used in the preparation of 6-ACA or caprolactam.
摘要翻译： 本发明涉及使用生物催化剂制备6-氨基己酸（以下也称为“6-ACA”）的方法。 本发明还涉及通过环化这种6-ACA制备ε-己内酰胺（以下称为“己内酰胺”）的方法。 本发明还涉及可用于制备6-ACA或己内酰胺的宿主细胞，微生物或多核苷酸。
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公开(公告)号：US09096873B2
公开(公告)日：2015-08-04
申请号：US12921547
申请日：2009-03-11
申请人： Liang Wu , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman , Marco Alexander Van Den Berg
发明人： Liang Wu , Axel Christoph Trefzer , Stefaan Marie Andre De Wildeman , Marco Alexander Van Den Berg
摘要： The present invention relates to a method for preparing an adipate ester or thioester. The invention further relates to a method for preparing adipic acid from said ester or thioester. Further the invention provides a number of methods for preparing an intermediate for said ester or thioester. Further the invention relates to a method for preparing 6-amino caproic acid (6-ACA), a method for preparing 5-formyl valeric acid (5-FVA), and a method for preparing caprolactam. Further, the invention relates to a host cell for use in a method according to the invention.
摘要翻译： 本发明涉及一种制备己二酸酯或硫酯的方法。 本发明还涉及从所述酯或硫酯制备己二酸的方法。 此外，本发明提供了许多用于制备所述酯或硫酯的中间体的方法。 本发明还涉及制备6-氨基己酸（6-ACA）的方法，5-甲酰戊酸（5-FVA）的制备方法和己内酰胺的制备方法。 此外，本发明涉及用于根据本发明的方法的宿主细胞。
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