公开(公告)号：US20170143668A1

公开(公告)日：2017-05-25

申请号：US15415883

申请日：2017-01-26

Applicant: Macau University of Science and Technology

Inventor： Wen-zhe MA ,  Sen-ling FENG ,  Xiao-jun YAO ,  Zhong-wen YUAN ,  Liang LIU ,  Ying XIE

IPC: A61K31/366 ,  A61K31/704 ,  A61K31/337

CPC classification number: A61K31/366 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

公开(公告)号：US20170128394A1

公开(公告)日：2017-05-11

申请号：US14971153

申请日：2015-12-16

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Thomas Efferth ,  Su-Wei Xu ,  Sami Hamdoun ,  Liang Liu

IPC: A61K31/19 ,  A61K31/553 ,  A61K31/704 ,  A61K31/7048 ,  A61K31/337 ,  A61K33/24

CPC classification number: A61K31/19 ,  A61K31/337 ,  A61K31/553 ,  A61K31/704 ,  A61K31/7048 ,  A61K33/24 ,  A61K2300/00

Abstract: A quinonemethide triterpenoid is administered to subjects with multidrug-resistant cancer, in particular a cancer with enhanced expression and/or functional activity of ABC transporter proteins such as P-glycoprotein and/or an apoptosis-deficient, in particular p53-, Bax- or Bak-deficient, cancer, i.e. specific subgroups of subjects with cancer. The quinonemethide triterpenoid is suitable to treat cancer allowing for an accumulation of cytotoxic or therapeutic compounds in the cells while having exceptionally increased cytotoxic activity towards the multidrug-resistant cancer cells and while allowing for an increased activity of chemotherapeutic compounds. Methods for specifically targeting cancer cells with multidrug-resistance and methods for potentiating the activity of a chemotherapeutic compound in those cancer cells are also disclosed. A kit including a quinonemethide triterpenoid and a chemotherapeutic compound is also provided.

公开(公告)号：US09618930B1

公开(公告)日：2017-04-11

申请号：US14918557

申请日：2015-10-20

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Yan Qiao ,  Mengchu Zhou

IPC: G05B19/418 ,  B25J9/16 ,  H01L21/67 ,  H01L21/677 ,  H01L21/68

CPC classification number: G05B19/41885 ,  B25J9/1669 ,  G05B19/41865 ,  G05B2219/39536 ,  G05B2219/45031 ,  H01L21/67276 ,  H01L21/67745

Abstract: Due to the trend of using larger wafer diameter and smaller lot size, cluster tools need to switch from processing one lot of wafers to another frequently. It leads to more transient periods in wafer fabrication. Their efficient scheduling and control problems become more and more important. It becomes difficult to solve such problems, especially when wafer residency time constraints must be considered. This work develops a Petri net model to describe the behavior during the start-up transient processes of a single-arm cluster tool. Then, based on the model, for the case that the difference of workloads among the steps is not too large and can be properly balanced, a scheduling algorithm to find an optimal feasible schedule for the start-up process is given. For other cases schedulable at the steady state, a linear programming model is developed to find an optimal feasible schedule for the start-up process.

公开(公告)号：US20170083008A1

公开(公告)日：2017-03-23

申请号：US14918577

申请日：2015-10-21

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Qinghua Zhu ,  Yan Qiao ,  Mengchu Zhou

IPC: G05B19/418

CPC classification number: G05B19/4187 ,  G05B2219/45031 ,  G05B2219/50291 ,  Y02P90/205 ,  Y02P90/26

Abstract: The scheduling problem of a multi-cluster tool with a tree topology whose bottleneck tool is process-bound is investigated. A method for scheduling the multi-cluster tool to thereby generate an optimal one-wafer cyclic schedule for this multi-cluster tool is provided. A Petri net (PN) model is developed for the multi-cluster tool by explicitly modeling robot waiting times such that a schedule is determined by setting the robot waiting times. Based on the PN model, sufficient and necessary conditions under which a one-wafer cyclic schedule exists are derived and it is shown that an optimal one-wafer cyclic schedule can be always found. Then, efficient algorithms are given to find the optimal cycle time and its optimal schedule. Examples are used to demonstrate the scheduling method.

公开(公告)号：US20170080563A1

公开(公告)日：2017-03-23

申请号：US14918557

申请日：2015-10-20

Applicant: Macau University of Science and Technology

Inventor： Naiqi Wu ,  Yan Qiao ,  Mengchu Zhou

IPC: B25J9/16 ,  H01L21/677 ,  H01L21/68 ,  H01L21/67

CPC classification number: G05B19/41885 ,  B25J9/1669 ,  G05B19/41865 ,  G05B2219/39536 ,  G05B2219/45031 ,  H01L21/67276 ,  H01L21/67745

Abstract: Due to the trend of using larger wafer diameter and smaller lot size, cluster tools need to switch from processing one lot of wafers to another frequently. It leads to more transient periods in wafer fabrication. Their efficient scheduling and control problems become more and more important. It becomes difficult to solve such problems, especially when wafer residency time constraints must be considered. This work develops a Petri net model to describe the behavior during the start-up transient processes of a single-arm cluster tool. Then, based on the model, for the case that the difference of workloads among the steps is not too large and can be properly balanced, a scheduling algorithm to find an optimal feasible schedule for the start-up process is given. For other cases schedulable at the steady state, a linear programming model is developed to find an optimal feasible schedule for the start-up process.

公开(公告)号：US09561220B2

公开(公告)日：2017-02-07

申请号：US14985414

申请日：2015-12-31

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Liang Liu ,  Jingrong Wang

IPC: A61K31/4745 ,  A61K31/4725 ,  A61K31/4748

CPC classification number: A61K31/4745 ,  A61K31/4725 ,  A61K31/4748

Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.

Abstract translation: 本发明公开了一种治疗癌症的方法，该方法包括给予有效量的生物碱，其中生物碱为留丝氨酸，依沙星碱，屈酸，去甲肾上腺素，栀子或沙利度胺，并从中药中分离出来。 还公开了使用生物碱治疗神经变性疾病。

公开(公告)号：US20170027901A1

公开(公告)日：2017-02-02

申请号：US14848358

申请日：2015-09-09

Applicant: Macau University of Science and Technology

Inventor： Wen-zhe MA ,  Sen-ling FENG ,  Xiao-jun YAO ,  Zhong-wen YUAN ,  Liang LIU ,  Ying XIE

IPC: A61K31/353 ,  A61K31/704 ,  A61K31/337

CPC classification number: A61K31/366 ,  A61K31/337 ,  A61K31/352 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is nobiletin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

Abstract translation: 本发明公开了一种治疗多药耐药性的药物组合物，其包含柑橘类甲氧基黄酮和化学治疗药物，其中柑橘类甲氧基黄酮是诺贝利林。 还公开了一种治疗多药耐药性的方法，其包括施用柑橘甲氧基黄酮和化疗药物。

公开(公告)号：US20170027900A1

公开(公告)日：2017-02-02

申请号：US14848360

申请日：2015-09-09

Applicant: Macau University of Science and Technology

Inventor： Wen-zhe MA ,  Sen-ling FENG ,  Xiao-jun YAO ,  Zhong-wen YUAN ,  Liang LIU ,  Ying XIE

IPC: A61K31/352 ,  A61K31/704 ,  A61K31/337

CPC classification number: A61K31/352 ,  A61K31/337 ,  A61K31/704 ,  A61K45/06 ,  A61K2300/00

Abstract: The present invention discloses a pharmaceutical composition of treating multidrug resistance cancer, comprising a citrus methoxyflavone and a chemotherapeutic drug, in which the citrus methoxyflavone is tangeretin. A method of treating multidrug resistance cancer comprising administrating citrus methoxyflavone and a chemotherapeutic drug is also disclosed.

Abstract translation: 本发明公开了一种治疗多药耐药性的药物组合物，其包含柑橘类甲氧基黄酮和化学治疗药物，其中柑橘类甲氧基黄酮为甜菜碱。 还公开了一种治疗多药耐药性的方法，其包括施用柑橘甲氧基黄酮和化疗药物。

公开(公告)号：US09439898B2

公开(公告)日：2016-09-13

申请号：US14296477

申请日：2014-06-05

Applicant: Macau University of Science and Technology

Inventor： Elaine Lai-Han Leung ,  Liang Liu ,  Xing-Xing Fan

IPC: C12Q1/68 ,  A61K31/4741 ,  A61K33/40 ,  G01N33/50

CPC classification number: A61K31/4741 ,  A61K33/40 ,  C12Q1/6886 ,  C12Q2600/136 ,  C12Q2600/156 ,  G01N33/5011 ,  G01N2333/90209 ,  G01N2333/91205 ,  A61K2300/00

Abstract: The present invention relates to methods for novel drug discovery, treatment and selective targeting for Gefitinib-resistant non-small-cell lung cancer (NSCLC) harboring an additional mutation, in particular, to the discovery of a drug candidate or agent identified by the presently claimed method for use in treating and selective targeting Gefitinib-resistant NSCLC harboring T790M mutation.

Abstract translation: 本发明涉及具有另外突变的吉非替尼耐药性非小细胞肺癌（NSCLC）的新药物发现，治疗和选择性靶向的方法，特别涉及目前鉴定的候选药物或药物的发现 所述方法用于治疗和选择性靶向具有T790M突变的吉非替尼耐药性NSCLC。

公开(公告)号：US20160106734A1

公开(公告)日：2016-04-21

申请号：US14985420

申请日：2015-12-31

Applicant: Macau University of Science and Technology

Inventor： Kam Wai Wong ,  Yuen Kwan Law ,  Liang Liu ,  Jingrong Wang

IPC: A61K31/4748 ,  A61K31/4725

CPC classification number: A61K31/4745 ,  A61K31/4725 ,  A61K31/4748

Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.