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1.发明授权公开(公告)号：US11648258B2
公开(公告)日：2023-05-16
申请号：US14399960
申请日：2013-05-09
Applicant: The Hong Kong University Of Science And Technology , Hong Kong Baptist University , Macau University Of Science And Technology
Inventor： Chun Liang , Zhihong Jiang , Ziyi Wang , Zhiling Yu , Jingrong Wang , Liping Bai
IPC: A61K31/7048 , A61K31/585 , G01N33/50 , G01N33/574
CPC classification number: A61K31/7048 , A61K31/585 , G01N33/5011 , G01N33/5044 , G01N33/574 , G01N2458/00 , G01N2500/10
Abstract: A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.
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公开(公告)号：US09561223B2
公开(公告)日：2017-02-07
申请号：US14985420
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai Wong , Yuen Kwan Law , Liang Liu , Jingrong Wang
IPC: A61K31/4725 , A61K31/4745 , A61K31/4748
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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3.发明公开公开(公告)号：US20230293564A1
公开(公告)日：2023-09-21
申请号：US18135229
申请日：2023-04-17
Applicant: The Hong Kong University Of Science And Technology , Hong Kong Baptist University , Macau University Of Science And Technology
Inventor： Chun LIANG , Zhihong JIANG , Ziyi Wang , Zhiling Yu , Jingrong Wang , Liping Bai
IPC: A61K31/7048 , G01N33/50 , G01N33/58 , A61P35/00
CPC classification number: A61K31/7048 , G01N33/5011 , G01N33/582 , A61P35/00
Abstract: A method for treating cancer by using an agent which is capable of inhibiting the functionality of the MCM complex, a heterohexameric ring formed from six subunits, in the process of DNA replication and a method of screening for such agents by detecting the locations and functions of the MCM subunits, such as hMcm2 and hMcm6, in cells treated with candidate compounds.
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公开(公告)号：US09561221B2
公开(公告)日：2017-02-07
申请号：US14985417
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai Wong , Yuen Kwan Law , Liang Liu , Jingrong Wang
IPC: A61K31/4725 , A61K31/4745 , A61K31/4748
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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公开(公告)号：US11377418B2
公开(公告)日：2022-07-05
申请号：US17110567
申请日：2020-12-03
Applicant: Macau University of Science and Technology
Inventor： Zhi-Hong Jiang , Nanshan Zhong , Zifeng Yang , Jingrong Wang , Qitong Feng , Xiaobo Zhou , Beixian Zhou
IPC: C07C233/87
Abstract: A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.
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Patent Agency Ranking
公开(公告)号：US09561222B2
公开(公告)日：2017-02-07
申请号：US14985419
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai Wong , Yuen Kwan Law , Liang Liu , Jingrong Wang
IPC: A61K31/4725 , A61K31/4745 , A61K31/4748
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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公开(公告)号：US09561219B2
公开(公告)日：2017-02-07
申请号：US14985408
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai Wong , Yuen Kwan Law , Liang Liu , Jingrong Wang
IPC: A61K31/4725 , A61K31/4745 , A61K31/4748
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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公开(公告)号：US20220127220A1
公开(公告)日：2022-04-28
申请号：US17110567
申请日：2020-12-03
Applicant: Macau University of Science and Technology
Inventor： Zhi-Hong Jiang , Nanshan Zhong , Zifeng Yang , Jingrong Wang , Qitong Feng , Xiaobo Zhou , Beixian Zhou
IPC: C07C233/87
Abstract: A compound including a structure of Formula (I) and a preparation method thereof, wherein R1 is —OH, —CH2OH, or —OCOCH3; R2, R3, and R4 are independently —H, —CH3 or —F, and at least one of R2, R3, and R4 is —F. A method for treating a subject suffering from a viral disease includes administering an effective amount of said compound or a solvate thereof to the subject.
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9.发明授权Group of alkaloids, the novel autophagic enhancers for treatment of cancers and neurodegenerative conditions thereof 有权生物碱组，用于治疗癌症的新型自噬增强剂及其神经变性病症公开(公告)号：US09561220B2
公开(公告)日：2017-02-07
申请号：US14985414
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai Wong , Yuen Kwan Law , Liang Liu , Jingrong Wang
IPC: A61K31/4745 , A61K31/4725 , A61K31/4748
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
Abstract translation: 本发明公开了一种治疗癌症的方法，该方法包括给予有效量的生物碱，其中生物碱为留丝氨酸，依沙星碱，屈酸，去甲肾上腺素，栀子或沙利度胺，并从中药中分离出来。 还公开了使用生物碱治疗神经变性疾病。
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公开(公告)号：US20160106734A1
公开(公告)日：2016-04-21
申请号：US14985420
申请日：2015-12-31
Applicant: Macau University of Science and Technology
Inventor： Kam Wai Wong , Yuen Kwan Law , Liang Liu , Jingrong Wang
IPC: A61K31/4748 , A61K31/4725
CPC classification number: A61K31/4745 , A61K31/4725 , A61K31/4748
Abstract: The present invention discloses a method of treating cancer comprising administering an effective amount of an alkaloid, in which the alkaloid is liensinine, isoliensinine, dauricine, cepharanthine, hernandezine or thalidezine and isolated from the traditional Chinese medicinal herbs. The use of the alkaloid in treating neurodegenerative disorder is also disclosed.
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