公开(公告)号：US20140057979A1

公开(公告)日：2014-02-27

申请号：US14053623

申请日：2013-10-15

Applicant: Shiseido Company, Ltd.

Inventor： Yoko Gozu ,  Shinichiro Haze

IPC: A61K31/336 ,  C07C69/78 ,  C07C229/38 ,  C07C229/60

CPC classification number: A61K31/336 ,  A61K31/216 ,  A61K31/618 ,  C07C69/78 ,  C07C229/38 ,  C07C229/60

Abstract: The present invention provides substances that can be used in a broad range of applications and effectively regulate clock gene expression.Provided is a clock gene expression regulating agent comprising, as an active ingredient, one or more selected from the group consisting of caryophyllene oxide and compounds represented by the following structural formula: wherein X is CH3, NH2 or NHCH3.

Abstract translation: 本发明提供可用于广泛应用并有效调节时钟基因表达的物质。 本发明提供一种时钟基因表达调节剂，其包含选自由以下结构式表示的石竹烯氧化物和其中X为CH 3，NH 2或NHCH 3的化合物作为活性成分的一种或多种。

公开(公告)号：US20130253076A1

公开(公告)日：2013-09-26

申请号：US13799317

申请日：2013-03-13

Applicant: TAKASAGO INTERNATIONAL CORPORATION ,  SHISEIDO COMPANY, LTD.

Inventor： Atushi JOICHI ,  Yasuko NAKAMURA ,  Shinichiro HAZE ,  Takahiro ISHIKAWA ,  Takashi NISHIDA ,  Kazutoshi SAKURAI

IPC: C11B9/00

CPC classification number: C11B9/0096 ,  A61K8/37 ,  A61K8/49 ,  A61Q5/00 ,  A61Q5/02 ,  A61Q13/00 ,  A61Q15/00 ,  A61Q19/00 ,  A61Q19/10 ,  C11B9/003

Abstract: A rose-like fragrance composition including methyl epijasmonate, provided that a natural jasmine fragrance containing methyl epijasmonate is excluded. The rose-like fragrance composition can also include 2-isopropyl-4-methyl thiazole.

Abstract translation: 一种玫瑰状香料组合物，其中包括上睑甲酸甲酯，条件是排除含有上睑甲酸甲酯的天然茉莉香精。 玫瑰状香料组合物还可以包括2-异丙基-4-甲基噻唑。

公开(公告)号：US20130093110A1

公开(公告)日：2013-04-18

申请号：US13707435

申请日：2012-12-06

Applicant: SHISEIDO COMPANY LTD.

Inventor： Kei Watanabe ,  Hidefumi Araki ,  Yuko Nagare ,  Yasunari Nakama ,  Hirokazu Ishino

IPC: A61K8/02

CPC classification number: A61K8/0241 ,  A61K8/14 ,  A61K8/34 ,  A61K8/345 ,  A61K8/891 ,  A61K8/894 ,  A61Q5/12 ,  A61Q13/00 ,  A61Q19/00

Abstract: To provide a vesicle-containing composition wherein a perfume component is stably incorporated in the vesicle bilayer membrane composed of a silicone surfactant and to provide a simple production method of the vesicle-containing composition wherein a perfume component is stably incorporated. A vesicle-containing composition comprising; (A) a perfume, (B) a silicone oil, (C) a silicone surfactant, (D) one or more selected from the group consisting of ethanol, propylene glycol, dipropylene glycol, and 1,3-butylene glycol, and (E) water; wherein the (C) silicone surfactant forms vesicles, and the (A) perfume and the (B) silicone oil are present in the vesicle bilayer membrane.

Abstract translation: 本发明提供一种含有囊泡的组合物，其中将香料成分稳定地并入由硅氧烷表面活性剂构成的囊泡双层膜中，并提供其中稳定地配合香料成分的含囊泡组合物的简单制造方法。 一种含囊泡的组合物，其包含： （A）香料，（B）硅油，（C）有机硅表面活性剂，（D）选自乙醇，丙二醇，二丙二醇和1,3-丁二醇中的一种或多种，​​和（D） E）水; 其中（C）硅氧烷表面活性剂形成囊泡，并且（A）香料和（B）硅油存在于泡囊双层膜中。

公开(公告)号：US20030134264A1

公开(公告)日：2003-07-17

申请号：US10162738

申请日：2002-06-06

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kazuhisa Maeda ,  Masato Hatao

IPC: C12Q001/00 ,  A61K007/42 ,  A61K031/375

CPC classification number: A61Q17/04 ,  A61K8/492 ,  A61K8/676 ,  A61Q19/02

Abstract: A method of preventing darkening of the skin or inhibiting melanization caused by the irradiation of the melanin monomers with long wavelength ultraviolet rays having a wavelength of 320-400 nm as well as a polymerization inhibitor of a biological dihydroxyindole compound comprising 3-O-ethyl ascorbic acid and an external skin treatment composition containing the same.

Abstract translation: 防止由波长320-400nm的长波长紫外线照射黑色素单体引起的皮肤变黑或抑制黑色素化的方法，以及包含抗坏血酸3-O-乙酸的生物二羟基吲哚化合物的阻聚剂 酸和含有其的外用皮肤治疗组合物。

公开(公告)号：US20250099361A1

公开(公告)日：2025-03-27

申请号：US18833682

申请日：2023-02-14

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Kazuki MASUDA

IPC: A61K8/81 ,  A61K8/06 ,  A61K8/25 ,  A61K8/37 ,  A61K8/73 ,  A61K8/92 ,  A61Q17/04

Abstract: An objective of the invention is to provide an oil-in-water emulsion cosmetic with a transparent to translucent appearance, that can stably and finely emulsify even a relatively large amount of a polar oil with a small amount of a surfactant. The oil-in-water emulsion cosmetic according to the present invention is characterized by containing (A) a non-ionic surfactant that has an HLB of 8 to 12; (B) a polar oil that is liquid at 25° C. and that has an IOB of 0.1 or higher; and (C) a water-soluble solvent; wherein the (A)/(B) ratio is 0.4 to 3.

公开(公告)号：US20250073151A1

公开(公告)日：2025-03-06

申请号：US18726502

申请日：2023-01-20

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Ikuhiro SUZUKI

IPC: A61K8/49 ,  A61K8/67 ,  A61Q19/02 ,  A61Q19/08

Abstract: [Object] Provided is an external-use skin preparation composition that effectively inhibits tyrosinase activity and elastase activity.
[Solution] An external-use skin preparation composition comprising (A) a cyclic carboxamide derivative having a specific structure or a salt thereof, and (B) Vitamin B6.

公开(公告)号：US20250073150A1

公开(公告)日：2025-03-06

申请号：US18726524

申请日：2023-01-20

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Ikuhiro SUZUKI

IPC: A61K8/49 ,  A61K8/60 ,  A61Q19/08

Abstract: [Object] Provided is an external-use skin preparation composition that effectively inhibits elastase activity.
[Solution] An external-use skin preparation composition comprising (A) a cyclic carboxamide derivative having a specific structure or a salt thereof, and (B) adenosine, an adenosine derivative or a salt thereof.

公开(公告)号：US20250064702A1

公开(公告)日：2025-02-27

申请号：US18711955

申请日：2022-12-08

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Seiji NISHIKAWA ,  Ikuhiro SUZUKI ,  Yusuke OKUYAMA

IPC: A61K8/49 ,  A61K8/06 ,  A61K8/36 ,  A61Q19/08

Abstract: [Problem] To provide an oil-in-water emulsion cosmetic having an excellent feel in use.
[Solution] An oil-in-water emulsion cosmetic comprising (A) a cyclic carboxamide derivative having a specific structure or its salt, (B) a straight-chain higher fatty acid having 16 or more carbon atoms, (C) a higher alcohol, (D) a nonionic surfactant, (E) an oil, and (F) water.

公开(公告)号：US20250041189A1

公开(公告)日：2025-02-06

申请号：US18706991

申请日：2022-11-18

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Shunsuke IRIYAMA

IPC: A61K8/49 ,  A61K8/9711 ,  A61K8/9717 ,  A61K8/9722 ,  A61Q19/08

Abstract: The present disclosure relates to providing a substance and a composition that promote the proliferation of epidermal stem cells and are effective in improving wrinkles and barrier function from the viewpoint of maintaining or improving quality of life (QOL) in terms of both health and beauty. More specifically, a composition including 1-(2-hydroxyethyl)-2-imidazolidinone (HEI) or a derivative thereof and a seaweed extract such as Marinwort IPC-12 AGS can be used to promote the proliferation of epidermal stem cells and obtain a beneficial effect on wrinkles and barrier function.

公开(公告)号：US20250026890A1

公开(公告)日：2025-01-23

申请号：US18712061

申请日：2022-12-07

Applicant: SHISEIDO COMPANY, LTD. ,  The University of Tokyo

Inventor： Ayano MATSUO ,  Renaud GILLET ,  Atsushi SOGABE ,  Satoshi HONDA ,  Minami OKA

IPC: C08G77/442 ,  C08G77/52

Abstract: A polymer compound in which coumarin or a derivative thereof is bonded to at least one terminal of a skeletal polymer. A flow property of the polymer compound is reversibly changeable from a first state to a second state by irradiation with light at a first wavelength and from the second state to the first state by irradiation with light at a second wavelength different from the first wavelength.