公开(公告)号：US20230210928A1

公开(公告)日：2023-07-06

申请号：US18068406

申请日：2022-12-19

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Shunsuke IRIYAMA ,  Saori TANNO

IPC: A61K31/4166 ,  C12N9/24 ,  C12N9/50

CPC classification number: A61K31/4166 ,  C12N9/2402 ,  C12N9/50 ,  C12Y302/01166 ,  C12Y304/24035

Abstract: The purpose of this invention is to provide a method with which it is easy to perform screening for an agent that proliferates or an agent that minimizes the reduction in MCSP-positive basal epidermal stem cells. Provided is a screening method for a laminin 511 expression promoter, which takes the expression of laminin 511 as an indicator. Also provided is an agent for improving skin barrier function, elasticity, hydration and inflammation, said agent including at least one extract selected from among a group consisting of brown algae, red algae and green algae.

公开(公告)号：US20150335692A1

公开(公告)日：2015-11-26

申请号：US14818554

申请日：2015-08-05

Applicant: Shiseido Company, Ltd.

Inventor： Shunsuke IRIYAMA ,  Yukiko MATSUNAGA ,  Satoshi AMANO ,  Kenichi UMISHIO ,  Ken KUSAKARI ,  Takuya HIRUMA

IPC: A61K36/23 ,  A61K36/14 ,  A61K36/752 ,  A61K36/81 ,  A61K36/8962 ,  G01N33/573 ,  A61K36/725 ,  A61K8/97 ,  A61Q19/08 ,  A61Q19/00 ,  A61K9/00 ,  A61K36/185 ,  A61K36/8967

CPC classification number: A61K36/00 ,  A61K8/4946 ,  A61K8/66 ,  A61K8/97 ,  A61K9/0014 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/17 ,  A61K31/4184 ,  A61K36/14 ,  A61K36/18 ,  A61K36/185 ,  A61K36/23 ,  A61K36/725 ,  A61K36/73 ,  A61K36/75 ,  A61K36/752 ,  A61K36/81 ,  A61K36/896 ,  A61K36/8962 ,  A61K36/8967 ,  A61K2800/5922 ,  A61K2800/91 ,  A61K2800/92 ,  A61Q19/007 ,  A61Q19/08 ,  G01N33/573 ,  G01N2333/924 ,  G01N2500/04 ,  G01N2500/10

Abstract: Wrinkles are improved by applying an oral preparation, injection preparation or external skin preparation having a substance that controls heparanase as an active ingredient thereof.

Abstract translation: 通过应用具有控制肝素酶作为其活性成分的物质的口服制剂，注射制剂或外用皮肤制剂来改善皱纹。

公开(公告)号：US20150011593A1

公开(公告)日：2015-01-08

申请号：US14496534

申请日：2014-09-25

Applicant: Shiseido Company, Ltd.

Inventor： Shunsuke IRIYAMA ,  Kenichi UMISHIO ,  Makoto TSUNENAGA ,  Shinji INOMATA ,  Eijiro ADACHI

IPC: A61K31/4406 ,  A61F2/10 ,  A61L27/36 ,  A61K31/4184 ,  A61L27/60

CPC classification number: A61K31/4406 ,  A61F2/105 ,  A61K8/4926 ,  A61K8/4946 ,  A61K8/64 ,  A61K31/4184 ,  A61K38/005 ,  A61K38/07 ,  A61K2800/782 ,  A61L27/362 ,  A61L27/3804 ,  A61L27/3813 ,  A61L27/3886 ,  A61L27/60 ,  A61Q19/08

Abstract: The present invention relates to a method for producing artificial skin, comprising: adding a matrix metalloproteinase inhibitor and a heparanase inhibitor to an artificial skin formation culture medium comprising human epidermal keratinocytes and human dermal fibroblasts, culturing the cells in the artificial skin formation culture medium, and forming artificial skin.

Abstract translation: 本发明涉及一种生产人造皮肤的方法，包括：将基质金属蛋白酶抑制剂和乙酰肝素酶抑制剂加入到人表皮角质形成细胞和人真皮成纤维细胞的人造皮肤形成培养基中，在人造皮肤形成培养基中培养细胞， 并形成人造皮肤。

公开(公告)号：US20250041189A1

公开(公告)日：2025-02-06

申请号：US18706991

申请日：2022-11-18

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Shunsuke IRIYAMA

IPC: A61K8/49 ,  A61K8/9711 ,  A61K8/9717 ,  A61K8/9722 ,  A61Q19/08

Abstract: The present disclosure relates to providing a substance and a composition that promote the proliferation of epidermal stem cells and are effective in improving wrinkles and barrier function from the viewpoint of maintaining or improving quality of life (QOL) in terms of both health and beauty. More specifically, a composition including 1-(2-hydroxyethyl)-2-imidazolidinone (HEI) or a derivative thereof and a seaweed extract such as Marinwort IPC-12 AGS can be used to promote the proliferation of epidermal stem cells and obtain a beneficial effect on wrinkles and barrier function.

公开(公告)号：US20230404885A1

公开(公告)日：2023-12-21

申请号：US18036755

申请日：2021-12-13

Applicant: Shiseido Company, Ltd.

Inventor： Ryozo TOBITA ,  Shunsuke IRIYAMA ,  Minami YAMADA

IPC: A61K8/49 ,  A61Q19/08 ,  C12N5/071

CPC classification number: A61K8/4946 ,  A61K8/4926 ,  A61Q19/08 ,  C12N5/0629

Abstract: The disclosure of the present invention relates to the provision of compositions effective for improving skin conditions from the viewpoint of maintaining or improving quality of life (QOL) in terms of both health and beauty. More specifically, the disclosure of the present invention relates to compositions comprising 1-(2-hydroxyethyl)-2-imidazoliclinone or a derivative thereof and pyriclinecarboxamide. As they promote the increase of epidermal stem cells and facilitate the proliferation of keratinocytes, they can be suitably used as a cosmetic composition such as cosmetics that are effective in improving skin conditions.

公开(公告)号：US20190275094A1

公开(公告)日：2019-09-12

申请号：US16343749

申请日：2017-10-20

Applicant: SHISEIDO COMPANY, LTD.

Inventor： Shunsuke IRIYAMA ,  Saori TANNO

IPC: A61K36/03 ,  C12N9/50 ,  C12N9/24 ,  A61P29/00 ,  G01N33/50

Abstract: The purpose of this invention is to provide a method with which it is easy to perform screening for an agent that proliferates or an agent that minimizes the reduction in MCSP-positive basal epidermal stem cells. Provided is a screening method for a laminin 511 expression promoter, which takes the expression of laminin 511 as an indicator. Also provided is an agent for improving skin barrier function, elasticity, hydration and inflammation, said agent including at least one extract selected from among a group consisting of brown algae, red algae and green algae.