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    Catheter positioning system
    252.
    发明申请
    Catheter positioning system 有权
    导管定位系统

    公开(公告)号：US20040181188A1

    公开(公告)日：2004-09-16

    申请号：US10805738

    申请日：2004-03-22

    Inventor： Alan K. Schaer ,  Michael D. Lesh

    IPC: A61M031/00

    CPC classification number: A61M25/0668 ,  A61B17/22012 ,  A61B18/1492 ,  A61B2017/003 ,  A61B2017/00867 ,  A61B2017/22038 ,  A61B2018/00214 ,  A61B2018/00285 ,  A61B2018/00577 ,  A61B2018/00839 ,  A61M2210/125 ,  A61N7/02 ,  C08L2201/12

    Abstract: The present invention relates to a system adapted to position a medical device, such as an ablation catheter, at a location where a pulmonary vein extends from an atrium. The system optimally comprises a deflectable catheter and a sheath. An ablation member is disclosed for use with the positioning system, wherein the deflectable catheter and the sheath cooperate so as to facilitate positioning of the ablation member at the location.

    Abstract translation: 本发明涉及一种适于将医疗装置（例如消融导管）定位在肺静脉从心房延伸的位置处的系统。 系统最佳地包括可偏转导管和护套。 公开了一种与定位系统一起使用的消融构件，其中可偏转导管和护套配合，以便于消融构件在该位置的定位。

    Catheter design that facilitates positioning at tissue to be diagnosed or treated
    253.
    发明申请
    Catheter design that facilitates positioning at tissue to be diagnosed or treated 有权
    导管设计，便于定位在待诊断或治疗的组织

    公开(公告)号：US20040143254A1

    公开(公告)日：2004-07-22

    申请号：US10608257

    申请日：2003-06-27

    Inventor： Guy P. Vanney ,  Jeremy D. Dando

    IPC: A61B018/14

    CPC classification number: A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00065 ,  A61B2018/00375 ,  A61B2018/1472 ,  A61M25/0041 ,  C08L2201/12

    Abstract: A catheter used for diagnosing and treating, for example, atrial fibrillation. The catheter includes a catheter shaft that has a proximal portion and a distal portion. The distal portion is adapted to be inserted into a body cavity having tissue to be diagnosed or treated and is disposed remotely from the proximal portion. The distal portion, which may be curved or straight, comprises an outer peripheral wall having an active region, and the distal portion has a cross-sectional configuration along the active region. The cross-sectional configuration is adapted to bias the active region against the tissue to be diagnosed or treated.

    Abstract translation: 用于诊断和治疗例如心房颤动的导管。 导管包括具有近端部分和远端部分的导管轴。 远侧部分适于插入具有要被诊断或治疗的组织的体腔中并远离近端部分设置。 远侧部分可以是弯曲的或直的，包括具有活动区域的外周壁，并且远端部分沿着活动区域具有横截面构造。 横截面构造适于将活动区域偏压到待诊断或治疗的组织上。

    Shape memory thermoplastics and polymer networks for tissue engineering
    255.
    发明申请
    Shape memory thermoplastics and polymer networks for tissue engineering 审中-公开
    形状记忆热塑性塑料和组织工程的聚合物网络

    公开(公告)号：US20040110285A1

    公开(公告)日：2004-06-10

    申请号：US10297147

    申请日：2003-07-28

    Inventor： Andreas Lendlein ,  Ralf Knischka ,  Karl Kratz

    IPC: C12N005/08

    CPC classification number: A61L27/58 ,  A61L27/18 ,  A61L27/38 ,  B29C61/06 ,  B29K2995/006 ,  C08L67/04 ,  C08L2201/12 ,  C08L101/00

    Abstract: Methods and compositions are described herein for reconstruction of different functional tissues. Dissociated cells, differentiated cells, adult mesenchymal stem cells or embryonic stem cells are seeded on a scaffold. The scaffold will consist of a biocompatible, biodegradable shape memory (nullSMnull) polymers. In addition bioactive substances may be incorporated in the scaffold. Thermoplastic as well as thermoset materials with SM-effect can be used. The shape memory effect will be applied as an interactive link between the cells and the used polymeric scaffold. The degradation kinetics as well as shape memory transition temperature will be tailored by adjusting to monomer ratios of the co-oligomers. The shape memory effect will be used to create a degradation or release of bioactive substances on demand, induce forces on seeded cells or induce proliferation and differentiation of cells.

    Abstract translation: 本文描述了用于重建不同功能组织的方法和组合物。 将解离的细胞，分化细胞，成体间充质干细胞或胚胎干细胞接种在支架上。 支架将由生物相容的，可生物降解的形状记忆（“SM”）聚合物组成。 此外，生物活性物质可以并入支架中。 可以使用热塑性以及具有SM效应的热固性材料。 形状记忆效应将被用作细胞和使用的聚合物支架之间的交互式连接。 降解动力学以及形状记忆转变温度将通过调节共低聚物的单体比来调整。 形状记忆效应将用于根据需要产生生物活性物质的降解或释放，诱导种子细胞的力或诱导细胞的增殖和分化。

    RELEASABLE FASTENER SYSTEM AND PROCESS
    257.
    发明申请
    RELEASABLE FASTENER SYSTEM AND PROCESS 失效
    可释放的紧固件系统和过程

    公开(公告)号：US20040074066A1

    公开(公告)日：2004-04-22

    申请号：US10305424

    申请日：2002-11-26

    Inventor： John C. Ulicny ,  Mark A. Golden

    IPC: A44B018/00

    CPC classification number: A44B18/0003 ,  A41D2300/326 ,  A44B18/0007 ,  A44B18/0096 ,  A44D2203/00 ,  B64C33/02 ,  C08L2201/12 ,  F16B1/0014 ,  F16B5/00 ,  F16B5/07 ,  F16B2001/0028 ,  F16B2001/0035 ,  F16F2224/045 ,  H01L41/12 ,  H01L41/20 ,  Y10T24/27 ,  Y10T24/2742 ,  Y10T24/2792 ,  Y10T24/32 ,  Y10T24/33 ,  Y10T24/45482 ,  Y10T428/24017

    Abstract: A releasable fastener system comprises a loop portion and a hook portion. The loop portion includes a support and a loop material disposed on one side thereof whereas the hook portion includes a support and a plurality of closely spaced upstanding hook elements extending from one side thereof. When the hook portion and loop portion are pressed together they interlock to form a releasable engagement. The resulting joint created by the engagement is relatively resistant to shear and pull forces and weak in peel strength forces. The hook elements comprise a magnetic material that provides a change in shape orientation of the hook elements in response to an activation signal. In this manner, the shape orientation of the hook elements can be remotely changed to provide a reduction or magnification in the shear and/or pull-off forces.

    Abstract translation: 可释放的紧固件系统包括环部分和钩部分。 环部分包括支撑件和设置在其一侧的环形材料，而钩部分包括支撑件和从其一侧延伸的多个紧密间隔的直立钩形元件。 当钩部和环部被压在一起时，它们互锁以形成可释放的接合。 通过接合产生的所得到的接头相对于剪切力和拉力相对地抵抗并且剥离强度力弱。 钩元件包括响应于激活信号提供钩元件的形状取向的变化的磁性材料。 以这种方式，可以远程地改变钩元件的形状取向以在剪切力和/或拉力中提供减小或放大。

    Releasable fastener system
    258.
    发明申请
    Releasable fastener system 有权
    可拆卸紧固件系统

    公开(公告)号：US20040074064A1

    公开(公告)日：2004-04-22

    申请号：US10305381

    申请日：2002-11-26

    Inventor： Bob Ross Powell ,  Alan L. Browne

    IPC: A44B018/00

    CPC classification number: A44B18/0007 ,  A41D2300/326 ,  A44B18/0003 ,  A44B18/0096 ,  A44D2203/00 ,  B64C33/02 ,  C08L2201/12 ,  F16B1/0014 ,  F16B5/07 ,  F16B2001/0028 ,  F16B2001/0035 ,  F16F2224/045 ,  Y10T24/27 ,  Y10T24/2783 ,  Y10T29/49821 ,  Y10T428/24017

    Abstract: A releasable fastener system comprises a loop portion and a hook portion. The loop portion includes a support and a loop material disposed on one side thereof. The hook portion generally includes a support and a plurality of closely spaced upstanding hook elements extending from one side thereof, wherein the plurality of hook elements comprises a first portion fabricated from a shape memory material and at least one additional portion fabricated from a different shape memory material. An activation device is coupled to the plurality of hook elements, the activation device being operable to selectively provide an activation signal to the plurality of hook elements to change a shape orientation, a yield strength property, a flexural modulus property, or a combination thereof to reduce a shear force and/or a pull-off force of an engaged hook and loop portion. When the hook portion and loop portion are pressed together they interlock to form a releasable engagement. The resulting joint created by the engagement is relatively resistant to shear and pull forces and weak in peel strength forces. Introducing a suitable activation signal to the plurality of hook elements causes a change in shape orientation, flexural modulus property, or a combination thereof that is effectively reduces the shear and/or pull off forces in the releasable engagement. In this manner, disengagement of the releasable fastener system provides separation of the hook portion from the loop portion under controlled conditions. Also disclosed herein are processes for operating the releasable fastener system.

    Abstract translation: 可释放的紧固件系统包括环部分和钩部分。 环路部分包括支撑件和设置在其一侧的环形材料。 钩部通常包括支撑件和从其一侧延伸的多个紧密间隔的直立钩元件，其中多个钩元件包括由形状记忆材料制成的第一部分和由不同形状记忆体制成的至少一个附加部分 材料。 激活装置耦合到多个钩元件，激活装置可操作以选择性地向多个钩元件提供激活信号以改变形状取向，屈服强度特性，弯曲模量性质或其组合， 降低接合的钩和环部分的剪切力和/或拉力。 当钩部和环部被压在一起时，它们互锁以形成可释放的接合。 通过接合产生的所得到的接头相对于剪切力和拉力相对地抵抗并且剥离强度力弱。 向多个钩元件引入合适的激活信号导致形状取向，挠曲模量特性或其组合的改变，其有效地减少了可释放接合中的剪切力和/或拉力。 以这种方式，可释放的紧固件系统的分离在受控条件下提供了钩部分与环部分的分离。 本文还公开了用于操作可释放紧固件系统的方法。

    Releasable fastener system
    259.
    发明申请
    Releasable fastener system 有权
    可拆卸紧固件系统

    公开(公告)号：US20040074062A1

    公开(公告)日：2004-04-22

    申请号：US10305375

    申请日：2002-11-26

    Inventor： Thomas B. Stanford JR. ,  Alan L. Browne ,  Nancy L. Johnson ,  Leslie A. Momoda ,  William Barvosa-Carter ,  Bob R. Powell JR.

    IPC: A44B018/00

    CPC classification number: F16B1/0014 ,  A41D2300/326 ,  A44B18/0003 ,  A44B18/0096 ,  A44D2203/00 ,  C08L2201/12 ,  F16B5/07 ,  F16B2001/0028 ,  F16B2001/0035 ,  F16F2224/045 ,  Y10T24/27 ,  Y10T24/2783 ,  Y10T428/24017

    Abstract: A releasable fastener system comprises a loop portion and a hook portion. The loop portion includes a support and a loop material disposed on one side thereof. The hook portion generally includes a support and a plurality of closely spaced upstanding hook elements extending from one side thereof, wherein the plurality of hook elements comprises or incorporates a shape memory alloy fiber. When the hook portion and loop portion are pressed together they interlock to form a releasable engagement. The resulting joint created by the engagement is relatively resistant to shear and pull forces and weak in peel strength forces. Introducing a thermal activation signal to the plurality of hook elements causes a change in shape orientation, flexural modulus property, or a combination thereof that effectively reduces the shear and/or pull off forces in the releasable engagement. In this manner, disengagement of the releasable fastener system provides separation of the hook portion from the loop portion under controlled conditions. Also disclosed herein are processes for operating the releasable fastener system.

    Abstract translation: 可释放的紧固件系统包括环部分和钩部分。 环路部分包括支撑件和设置在其一侧的环形材料。 钩部通常包括支撑件和从其一侧延伸的多个紧密间隔的直立钩元件，其中多个钩元件包括或结合形状记忆合金纤维。 当钩部和环部被压在一起时，它们互锁以形成可释放的接合。 通过接合产生的所得到的接头相对于剪切力和拉力相对地抵抗并且剥离强度力弱。 向多个钩元件引入热激活信号导致形状取向，挠曲模量特性或其组合的改变，其有效地减少了可释放接合中的剪切力和/或拉拔力。 以这种方式，可释放的紧固件系统的分离在受控条件下提供了钩部分与环部分的分离。 本文还公开了用于操作可释放紧固件系统的方法。

    Atrial ablation catheter and method for treating atrial fibrillation
    260.
    发明申请
    Atrial ablation catheter and method for treating atrial fibrillation 有权
    心房消融导管及治疗房颤的方法

    公开(公告)号：US20040015164A1

    公开(公告)日：2004-01-22

    申请号：US10199525

    申请日：2002-07-19

    Inventor： Kristine B. Fuimaono ,  Irma P. Hill

    IPC: A61B018/18

    CPC classification number: A61B18/1492 ,  A61B2017/00867 ,  A61B2018/00351 ,  A61B2018/00791 ,  A61B2034/2051 ,  A61B2218/002 ,  C08L2201/12

    Abstract: A catheter for ablating tissue is provided. The catheter comprises an elongated generally-tubular catheter body having proximal and distal ends and at least one lumen extending therethrough. A non-retractable ablation assembly is attached to the distal end of the catheter body. The ablation assembly comprises proximal and distal non-conductive tubings, each having a lumen extending therethrough and a generally tubular electrode mounted between the proximal and distal non-conductive tubings. The tubular electrode is formed of a material having shape-memory and has at least one irrigation port through which fluid can pass from the inside to the outside of the electrode. The ablation assembly further comprises a non-conductive protective tubing extending generally parallel to and along the outside of the tubular electrode. The protective tubing has proximal and distal ends extending into the proximal and distal non-conductive tubings, respectively. The catheter further comprises at least one of an electrode lead wire and a temperature sensor wire, and preferably both, extending through the non-conductive protective tubing and catheter body, the electrode lead wire having a distal end mounted to a ring electrode mounted on the distal non-conductive tubing, and the temperature sensor wire having a distal end mounted on or under the distal non-conductive tubing. The catheter also comprises an infusion tube extending through the catheter body and having a distal end in fluid communication with the proximal end of the tubular electrode.

    Abstract translation: 提供用于消融组织的导管。 导管包括细长的大致管状的导管本体，其具有近端和远端以及延伸穿过其中的至少一个内腔。 不可缩回的消融组件附接到导管主体的远端。 消融组件包括近端和远端非导电管，每个具有延伸穿过其中的内腔和安装在近端和远端非导电管之间的大体管状电极。 管状电极由具有形状记忆的材料形成，并且具有至少一个冲洗口，流体可以通过该冲洗口从电极的内部传递到外部。 消融组件还包括大致平行于并沿着管状电极的外部延伸的非导电保护管。 保护管分别具有近端和远端非导电管道的近端和远端。 导管还包括电极引线和温度传感器线中的至少一个，并且优选地两者延伸穿过非导电保护管和导管主体，电极引线具有安装到安装在 远端非导电管，以及温度传感器线，其远端安装在远端非导电管上或下。 导管还包括延伸穿过导管主体并具有与管状电极的近端流体连通的远端的输注管。

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