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21.发明申请公开(公告)号：US20180326065A1
公开(公告)日：2018-11-15
申请号：US16041331
申请日：2018-07-20
IPC分类号： A61K47/02 , A61K9/20 , A61K47/32 , A61K31/5517
摘要： An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
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公开(公告)号：US20170143635A1
公开(公告)日：2017-05-25
申请号：US15426296
申请日：2017-02-07
IPC分类号： A61K9/20 , A61K31/485 , A61K31/4458 , A61K31/137 , A61K31/5517
CPC分类号： A61K47/38 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2054 , A61K9/2059 , A61K9/2072 , A61K31/137 , A61K31/4458 , A61K31/485 , A61K31/5517 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/32
摘要： Effective methods and compositions to deter abuse of pharmaceutical products (e.g., orally administered pharmaceutical products) including but not limited to immediate release, sustained or extended release and delayed release formulations for drugs subject to abuse comprising at least 10% by weight hydroxypropylcellulose; polyethylene oxide; and a disintegrant selected from the group consisting of crospovidone, sodium starch glycolate and croscarmellose sodium; wherein the ratio of hydroxypropylcellulose to polyethylene oxide on a weight basis is between about 10:1 and 1:10.
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23.发明授权Methods and compositions for self-regulated release of active pharmaceutical ingredient 有权用于自我调节释放活性药物成分的方法和组合物公开(公告)号：US09101636B2
公开(公告)日：2015-08-11
申请号：US14091817
申请日：2013-11-27
IPC分类号： A61K9/20 , A61K31/5517
CPC分类号： A61K47/02 , A61K9/2009 , A61K9/2027 , A61K9/2077 , A61K31/5517 , A61K47/32
摘要： An abuse deterrent pharmaceutical composition including a pharmaceutically active ingredient; an acid soluble ingredient; and a buffering ingredient; wherein the acid soluble ingredient and the buffering ingredient retard release of the active pharmaceutical ingredient when the composition is ingested in excess of an intended dosage.
摘要翻译： 包含药物活性成分的滥用威慑药物组合物; 酸溶性成分; 和缓冲成分; 其中当组合物摄取超过预期剂量时，酸溶性成分和缓冲成分阻止活性药物成分的释放。
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公开(公告)号：US20140336213A1
公开(公告)日：2014-11-13
申请号：US14339143
申请日：2014-07-23
发明人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
IPC分类号： A61K31/485 , A61K9/20
CPC分类号： A61K31/485 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2059 , A61K9/2095 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K47/32 , A61K47/34 , A61K47/38
摘要： This invention relates a therapeutic pharmaceutical composition comprising: a mixture including an opioid; polyethylene oxide in an amount of about 3 to about 40 wt % of the composition; a disintegrant; and a surfactant; wherein the disintegrant is present in an amount sufficient to cause the pharmaceutical composition to exhibit an immediate release profile.
摘要翻译： 本发明涉及治疗性药物组合物，其包含：包含阿片样物质的混合物; 该聚环氧乙烷的量为组合物的约3至约40重量％; 崩解剂 和表面活性剂; 其中所述崩解剂以足以使所述药物组合物呈现立即释放曲线的量存在。
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25.发明申请METHODS AND COMPOSITIONS FOR DETERRING ABUSE OF ORALLY ADMINISTERED PHARMACEUTICAL PRODUCTS 审中-公开用于确定药物滥用药物产品的方法和组合物公开(公告)号：US20130005823A1
公开(公告)日：2013-01-03
申请号：US13601239
申请日：2012-08-31
IPC分类号： A61K31/137
CPC分类号： A61K9/0043 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/74 , A61K45/06 , A61K2300/00
摘要： This invention relates to an abuse deterrent formulation of an oral dosage form of a therapeutically effective amount of any active drug substance that can be subject to abuse combined with a gel forming polymer, a nasal mucosal irritating surfactant and a flushing agent. Such a dosage form is intended to deter abuse of the active drug substance via injection, nasal inhalation or consumption of quantities of the dosage unit exceeding the usual therapeutically effective dose.
摘要翻译： 本发明涉及治疗有效量的任何活性药物的口服剂型的滥用威慑制剂，其可与凝胶形成聚合物，鼻粘膜刺激性表面活性剂和冲洗剂混合使用。 这种剂型旨在通过注射，鼻吸入或消耗超过通常治疗有效剂量的剂量单位的量来阻止活性药物物质的滥用。
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26.发明授权Extended release opioid abuse deterrent compositions and methods of making same 失效延迟释放阿片样物质滥用威慑成分及其制作方法公开(公告)号：US08101630B2
公开(公告)日：2012-01-24
申请号：US12383906
申请日：2009-03-30
申请人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
发明人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
CPC分类号： A61K31/485 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2059 , A61K9/2095 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K47/32 , A61K47/34 , A61K47/38
摘要： This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
摘要翻译： 本发明涉及一种阿片类镇痛药的滥用威慑剂型，其中将镇痛有效量的阿片类止痛剂与聚合物组合以形成基质。
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27.发明授权Methods and compositions for deterring abuse of drugs susceptible to abuse and dosage forms thereof 有权用于阻止滥用易受滥用药物滥用的方法和组合物及其剂型公开(公告)号：US07981439B2
公开(公告)日：2011-07-19
申请号：US12231136
申请日：2008-08-28
申请人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
发明人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
IPC分类号： A61K9/20 , A61K33/32 , A61K31/04 , A61K31/045 , A61K31/22
CPC分类号： A61K31/485 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2059 , A61K9/2095 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K47/32 , A61K47/34 , A61K47/38
摘要： This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
摘要翻译： 本发明涉及一种阿片类镇痛药的滥用威慑剂型，其中将镇痛有效量的阿片类止痛剂与聚合物组合以形成基质。
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28.发明申请Method and composition for deterring abuse of opioid containing dosage forms 失效用于阻止滥用含阿片样物质的剂型的方法和组合物公开(公告)号：US20090253730A1
公开(公告)日：2009-10-08
申请号：US12383906
申请日：2009-03-30
申请人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
发明人： Vijai Kumar , David Dixon , Divya Tewari , Dilip B. Wadgaonkar
IPC分类号： A61K31/485 , A61P25/36
CPC分类号： A61K31/485 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/2059 , A61K9/2095 , A61K9/2853 , A61K9/2866 , A61K9/2893 , A61K47/32 , A61K47/34 , A61K47/38
摘要： This invention relates to an abuse deterrent dosage form of opioid analgesics, wherein an analgesically effective amount of opioid analgesic is combined with a polymer to form a matrix.
摘要翻译： 本发明涉及一种阿片类镇痛药的滥用威慑剂型，其中将镇痛有效量的阿片类止痛剂与聚合物组合以形成基质。
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29.发明申请Methods and compositions for deterring abuse of orally administered pharmaceutical products 审中-公开用于阻止滥用口服药物的方法和组合物公开(公告)号：US20080152595A1
公开(公告)日：2008-06-26
申请号：US12001568
申请日：2007-12-12
IPC分类号： A61K9/00
CPC分类号： A61K9/0043 , A61K9/146 , A61K9/1635 , A61K9/1652 , A61K9/2009 , A61K9/2013 , A61K9/2027 , A61K9/2031 , A61K9/205 , A61K9/2054 , A61K9/2059 , A61K9/2095 , A61K9/4808 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K9/5026 , A61K9/5078 , A61K9/5084 , A61K31/74 , A61K45/06 , A61K2300/00
摘要： This invention relates to an abuse deterrent formulation of an oral dosage form of a therapeutically effective amount of any active drug substance that can be subject to abuse combined with a gel forming polymer, a nasal mucosal irritating surfactant and a flushing agent. Such a dosage form is intended to deter abuse of the active drug substance via injection, nasal inhalation or consumption of quantities of the dosage unit exceeding the usual therapeutically effective dose.
摘要翻译： 本发明涉及治疗有效量的任何活性药物的口服剂型的滥用威慑制剂，其可与凝胶形成聚合物，鼻粘膜刺激性表面活性剂和冲洗剂混合使用。 这种剂型旨在通过注射，鼻吸入或消耗超过通常治疗有效剂量的剂量单位的量来阻止活性药物物质的滥用。
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30.发明授权公开(公告)号：US11554114B2
公开(公告)日：2023-01-17
申请号：US16498746
申请日：2018-03-30
IPC分类号： A61K31/451 , A61K9/16 , A61K31/426 , A61K31/46 , A61K31/485 , A61K45/06 , A61K47/02 , A61K47/12 , A61K47/14 , A61K47/26 , A61K47/32 , A61K47/36 , A61K47/38 , A61K47/42 , A61K47/46
摘要： An abuse deterrent pharmaceutical composition including a drug susceptible to abuse, a first acid soluble ingredient, a first buffering ingredient, and a delayed release buffering component.
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