利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

1258 条记录 (耗时 0.04 秒)

    BICYCLIC HETEROCYCLE DERIVATIVES HAVING SELECTIVE BACE1 INHIBITORY ACTIVITY
    21.
    发明申请
    BICYCLIC HETEROCYCLE DERIVATIVES HAVING SELECTIVE BACE1 INHIBITORY ACTIVITY 有权

    公开(公告)号：US20210261561A1

    公开(公告)日：2021-08-26

    申请号：US17049818

    申请日：2019-04-22

    申请人： SHIONOGI & CO., LTD.

    发明人： Tatsuhiko UENO ,  Kouki FUCHINO ,  Kazuki TAKAHARA ,  Frederik ROMBOUTS ,  Dries VAN DEN BOSSCHE ,  Michel SURKYN ,  Michel DE CLEYN

    IPC分类号： C07D491/056 ,  C07D519/00 ,  A61P25/28

    摘要： The present invention provides a compound which has an effect of inhibiting amyloid ß production, especially an effect of inhibiting selective BACE1, and which is useful as a therapeutic or prophylactic agent for diseases induced by production, secretion and/or deposition of amyloid ß proteins.
    A compound of the formula (IA) or the like, wherein -A1- is alkylene optionally substituted with one or more halogen; R2 is substituted or unsubstituted alkyl or the like; R3 and R4 are each independently a hydrogen atom, halogen, alkyl or haloalkyl or the like; R5 is a hydrogen atom or halogen; A4 is N or CR6 wherein R6 is a hydrogen atom, halogen, or substituted or unsubstituted alkyl; A5 is NR7 or CR8R9; A6 is CR18 or N; R18 is a hydrogen atom; R7 is substituted or unsubstituted alkyl; R8 and R9 are each independently a hydrogen atom, halogen, alkyl or haloalkyl or the like; and Ring B is bicyclic ring; or a pharmaceutically acceptable salt thereof.

    Medicament for treating influenza characterized by combining a Cap-dependent endonuclease inhibitor and an anti-influenza drug
    22.
    发明授权
    Medicament for treating influenza characterized by combining a Cap-dependent endonuclease inhibitor and an anti-influenza drug 有权

    公开(公告)号：US11040048B2

    公开(公告)日：2021-06-22

    申请号：US16061495

    申请日：2016-12-14

    申请人： Shionogi & Co., Ltd.

    发明人： Takao Shishido ,  Takeshi Noshi ,  Atsuko Yamamoto ,  Mitsutaka Kitano

    IPC分类号： A61K31/685 ,  A61P31/16 ,  A61K31/196 ,  A61K31/351 ,  A61K31/426 ,  A61K31/506 ,  A61K31/53 ,  A61K31/5383 ,  A61K31/664 ,  A61K39/395 ,  A61K45/06

    摘要： A medicament characterized in that (A) a compound represented by the formula (I): its pharmaceutically acceptable salt, or a solvate thereof, wherein P is hydrogen or a group to form a prodrug; A1 is CR1AR1B, S or O; A2 is CR2AR2B, S or O; A3 is CR3AR3B, S or O; A4 is each independently CR4AR4B, S or O; the number of hetero atoms among atoms constituting the ring which consists of A1, A2, A3, A4, nitrogen atom adjacent to A1 and carbon atom adjacent to A4 is 1 or 2; R1A and R1B are each independently hydrogen, halogen, alkyl or the like; R2A and R2B are each independently hydrogen, halogen, alkyl, or the like; R3A and R3B are each independently hydrogen, halogen, alkyl, or the like; R4A are each independently hydrogen, halogen, alkyl, or the like; R4B are each independently hydrogen, halogen, alkyl, or the like; R3A and R3B may be taken together with an adjacent carbon atom to form non-aromatic carbocycle or non-aromatic heterocycle; n is any integer of 1 to 2; and R1 is or the like, is combined with (B) compound(s) having an anti-influenza activity, its pharmaceutically acceptable salt or a solvate thereof and/or an antibody having anti-influenza activity, is useful for treating or preventing influenza.