公开(公告)号：US20060166993A1

公开(公告)日：2006-07-27

申请号：US10520552

申请日：2003-06-25

Applicant: Martin Hendrix ,  David Bruckner ,  Arno Friedl ,  Irene Gerlach ,  Volker Hinz ,  Jorg Keldenich ,  Frank Mauler ,  Ulrich Niewohner ,  Maria Niewohner ,  Dagmar Karthaus ,  Karl-Heinz Schlemmer ,  Adrian Tersteegen ,  Ozkan Yalkinoglu

Inventor： Martin Hendrix ,  David Bruckner ,  Arno Friedl ,  Irene Gerlach ,  Volker Hinz ,  Jorg Keldenich ,  Frank Mauler ,  Ulrich Niewohner ,  Maria Niewohner ,  Dagmar Karthaus ,  Karl-Heinz Schlemmer ,  Adrian Tersteegen ,  Ozkan Yalkinoglu

IPC: A61K31/53 ,  C07D487/02

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: The invention relates to new substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of schizophrenia.

Abstract translation: 本发明涉及新的取代的咪唑并嗪，其制备方法及其用于生产用于治疗和/或预防癌症和神经变性疾病，特别是帕金森病和精神分裂症的药物的用途。

公开(公告)号：US08859569B2

公开(公告)日：2014-10-14

申请号：US13599975

申请日：2012-08-30

Applicant: Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Nils Griebenow ,  Dieter Lang ,  Frank Wunder ,  Walter Hübsch ,  Niels Lindner ,  Alexandros Vakalopoulos ,  Adrian Tersteegen

Inventor： Markus Follmann ,  Johannes-Peter Stasch ,  Gorden Redlich ,  Nils Griebenow ,  Dieter Lang ,  Frank Wunder ,  Walter Hübsch ,  Niels Lindner ,  Alexandros Vakalopoulos ,  Adrian Tersteegen

IPC: A01N43/90 ,  A61K31/519 ,  C07D487/00 ,  A61K31/541 ,  A61K31/5383 ,  A61K31/5377 ,  C07D498/08 ,  C07D519/00 ,  C07D471/04 ,  A61K45/06 ,  C07D487/04 ,  C07D491/20

CPC classification number: A61K31/519 ,  A61K31/527 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/5386 ,  A61K31/541 ,  A61K45/06 ,  C07D471/04 ,  C07D487/04 ,  C07D491/20 ,  C07D498/08 ,  C07D519/00

Abstract: The present application relates to novel substituted annellated pyrimidines, methods for production thereof, use thereof alone or in combinations for treating and/or preventing diseases and use thereof for the production of medicinal products for treating and/or preventing diseases, in particular for treating and/or preventing cardiovascular diseases.

Abstract translation: 本申请涉及新颖的取代的环状嘧啶，其制备方法，单独使用或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途，特别是用于治疗和/ /或预防心血管疾病。

公开(公告)号：US08822479B2

公开(公告)日：2014-09-02

申请号：US12950386

申请日：2010-11-19

Applicant: Martin Hendrix ,  Lars Bärfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin Hendrix ,  Lars Bärfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: A61K31/519 ,  A61P25/28 ,  A61P25/18 ,  C07D487/04

CPC classification number: C07D487/04 ,  A61K31/519

Abstract: The invention relates to 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving learning and/or memory. The 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines are of the formula (I): with the variables as defined in the claims.

Abstract translation: 本发明涉及6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于生产改善学习和/或记忆的药物的用途。 6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶具有式（I）：与权利要求中所定义的变量。

公开(公告)号：US08088769B2

公开(公告)日：2012-01-03

申请号：US10586501

申请日：2004-12-31

Applicant: Martin Hendrix ,  Lars Bärfacker ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen

Inventor： Martin Hendrix ,  Lars Bärfacker ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen

IPC: A61K31/519 ,  C07D487/04

CPC classification number: C07D239/47 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D405/06 ,  C07D405/12 ,  C07D405/14 ,  C07D409/06 ,  C07D409/14 ,  C07D491/10

Abstract: The invention relates to novel cyanopyrimidinones, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新颖的氰基嘧啶酮，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US08039477B2

公开(公告)日：2011-10-18

申请号：US10524956

申请日：2003-08-13

Applicant: Martin Hendrix ,  Frank-Gerhard Böβ ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

Inventor： Martin Hendrix ,  Frank-Gerhard Böβ ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

IPC: C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC classification number: C07D487/04

Abstract: The invention relates to novel alkyl-substituted pyrazolopyrimidines, process for their preparation, and the use thereof for producing medicaments for improving perception, concentration, learning and/or memory with compounds of formula (I):

Abstract translation: 本发明涉及新的烷基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善式（I）化合物的感知，浓度，学习和/或记忆的药物：

公开(公告)号：US20070161662A1

公开(公告)日：2007-07-12

申请号：US10556437

申请日：2004-04-27

Applicant: Martin Hendrix ,  Lars Barfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin Hendrix ,  Lars Barfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04 ,  A61K31/519

Abstract: The invention relates to novel 6-arylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新的6-芳基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US20070105876A1

公开(公告)日：2007-05-10

申请号：US10556224

申请日：2004-04-28

Applicant: Martin Hendrix ,  Lars Barfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin Hendrix ,  Lars Barfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04 ,  A61K31/519

Abstract: The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US07202243B2

公开(公告)日：2007-04-10

申请号：US10520552

申请日：2003-06-25

Applicant: Martin Hendrix ,  David Brückner ,  Arno Friedl ,  Irene Gerlach ,  Volker Hinz ,  Jörg Keldenich ,  Frank Mauler ,  Maria Niewöhner, legal representative ,  Dagmar Karthaus ,  Karl-Heinz Schlemmer ,  Adrian Tersteegen ,  Özkan Yalkinoglu

Inventor： Ulrich Niewöhner, deceased

IPC: C07D487/04 ,  A61K31/53 ,  A61P25/16 ,  A61P25/18

CPC classification number: C07D487/04 ,  A61K31/53

Abstract: The invention relates to new substituted imidazotriazines, processes for their preparation and their use for the production of medicaments for the treatment and/or prophylaxis of cancer and neurodegenerative disorders, in particular of Parkinson's disease and of schizophrenia.

Abstract translation: 本发明涉及新的取代的咪唑并嗪，其制备方法及其用于生产用于治疗和/或预防癌症和神经变性疾病，特别是帕金森病和精神分裂症的药物的用途。

公开(公告)号：US20060106035A1

公开(公告)日：2006-05-18

申请号：US10525115

申请日：2003-08-12

Applicant: Martin Hendrix ,  Frank-Gerhard Boss ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

Inventor： Martin Hendrix ,  Frank-Gerhard Boss ,  Nils Burkhardt ,  Christina Erb ,  Adrian Tersteegen ,  Marja Van Kampen

IPC: A61K31/519 ,  C07D487/02

CPC classification number: C07D487/04

Abstract: The invention relates to novel phenyl-substituted pyrazolopyrimidines, process for their preparation, and their use for producing medicaments for improving perception, concentration, learning and/or memory.

Abstract translation: 本发明涉及新的苯基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。

公开(公告)号：US08642605B2

公开(公告)日：2014-02-04

申请号：US13233833

申请日：2011-09-15

Applicant: Martin Hendrix ,  Lars Bärfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

Inventor： Martin Hendrix ,  Lars Bärfacker ,  Christina Erb ,  Frank-Thorsten Hafner ,  Heike Heckroth ,  Dagmar Karthaus ,  Adrian Tersteegen ,  Franz-Josef van der Staay ,  Marja van Kampen

IPC: C07D487/04 ,  A61K31/519 ,  A61P25/28

CPC classification number: C07D487/04 ,  A61K31/519

Abstract: The invention relates to novel 6-cyclylmethyl- and 6-alkylmethyl-substituted pyrazolopyrimidines, process for their preparation and their use for producing medicaments for improving perception, concentration, learning and/or memory. The pyrazolopyrimidine compounds are within the formula (I) as described herein.

Abstract translation: 本发明涉及新的6-环甲基 - 和6-烷基甲基取代的吡唑并嘧啶，其制备方法及其用于制备用于改善感知，浓度，学习和/或记忆的药物的用途。 吡唑并嘧啶化合物在本文所述的式（I）内。