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    Crosslinked hydrogels
    21.
    发明授权
    Crosslinked hydrogels 有权
    交联水凝胶

    公开(公告)号：US09078953B2

    公开(公告)日：2015-07-14

    申请号：US12747411

    申请日：2008-12-16

    申请人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    发明人： Kristin B. Kita ,  Nigel G. Smith ,  Anthony M. Lowman ,  Garland W. Fussell ,  Michael F. Keane

    IPC分类号： A61K31/79 ,  A61K31/785 ,  A61P43/00 ,  A61L27/16

    CPC分类号： A61L27/16

    摘要： The present invention preferably provides for a method of forming and the resulting solid polymer gel composition comprising polyethylene imine and at least one hydrogen bonding polymer. The composition has a greater viscosity than either of the polyethylene imine or the hydrogen bonding polymer alone and is injectable immediately after mixing of the polyethylene imine and the at least one hydrogen bonding polymer. A method of tissue repair may include mixing about 9.25% (w/w) to about 13.65% (w/w) polyethylene imine and about 18.02% (w/w) to about 26.62% (w/w) polyvinyl alcohol to form an injectable composition; injecting the injectable composition into a cavity within a human body; and allowing the composition to solidify in situ. A kit may include a multi-barrel syringe at least one barrel is loaded with polyethylene imine and at least another barrel is loaded with at least one hydrogen bonding polymer.

    摘要翻译： 本发明优选提供一种形成方法和所得到的固体聚合物凝胶组合物，其包含聚乙烯亚胺和至少一种氢键聚合物。 该组合物比单独的聚乙烯亚胺或氢键聚合物具有更大的粘度，并且在聚乙烯亚胺和至少一种氢键聚合物混合后立即进行注射。 组织修复的方法可包括混合约9.25％（w / w）至约13.65％（w / w）的聚乙烯亚胺和约18.02％（w / w）至约26.62％（w / w）的聚乙烯醇，以形成 可注射组合物 将可注射组合物注射到人体内的空腔中; 并使组合物原位固化。 套件可以包括多桶注射器，至少一个桶装有聚乙烯亚胺，并且至少另一个筒装有至少一个氢键聚合物。