公开(公告)号：US20250001132A1

公开(公告)日：2025-01-02

申请号：US18292145

申请日：2022-07-27

Applicant: The Trustees of the Stevens Institute of Technology ,  The Trustees of Columbia University in the City of New York ,  Stanford University

Inventor： Jinho Kim ,  Gordana VUNJAK-NOVAKOVIC ,  John D. O'NEILL ,  Meghan PINEZICH ,  Brandon A. Guenthart

IPC: A61M25/01 ,  A61M25/00

Abstract: The disclosed subject matter relates to a device, system and method for locating and repairing a pulmonary air leak in a patient.

公开(公告)号：US20240415625A1

公开(公告)日：2024-12-19

申请号：US18781138

申请日：2024-07-23

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Ishmail John ABDUS-SABOOR ,  Justin BURDGE ,  Z. Anissa JHUMKA ,  Jacob NAZARIAN, V ,  Tanya TABACHNIK

IPC: A61D7/00 ,  G03B17/56 ,  H04N23/695 ,  H04N23/74

Abstract: An animal positioned on a perforated platform can be stimulated in an automated fashion. Images of the animal's paw are captured using a bottom-view camera positioned below the platform. Based on these images, an upwards-pointing tool is moved until it is directly beneath the paw. The animal is then stimulated automatically by moving the tool upwards to contact the paw, then moving it back down to cease the contact. Images of the animal are captured using at least one side-view camera, and these images can be analyzed to ascertain the animal's response to the stimulus.

公开(公告)号：US20240408201A1

公开(公告)日：2024-12-12

申请号：US18814036

申请日：2024-08-23

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Mohsen Khosravi MAHARLOOEI ,  Remi CREUSOT ,  Megan SYKES

IPC: A61K39/00 ,  A61P37/06 ,  C07K16/28 ,  C12N5/0783 ,  C12N9/22 ,  C12N15/11 ,  C12N15/90

Abstract: CAR Tregs and Tregs are provided which are both conversion-resistant and condition-resistant. The Treg cells are engineered such that they are deficient in or substantially devoid of a cell-surface marker or antigen.

公开(公告)号：US20240402571A1

公开(公告)日：2024-12-05

申请号：US18309572

申请日：2023-04-28

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Yun Zhao ,  Jae K Jang ,  Yoshitomo Okawachi ,  Bok Young Kim ,  Alexander L Gaeta ,  Michal Lipson

IPC: G02F1/39 ,  G02F1/01

Abstract: Systems, methods, and devices for generating tunable low frequency signals, such as microwave and radiofrequency signals are disclosed. A first waveguide in optical communication with a first ring resonator can be configured to receive a light input and generate frequencies via optical parametric oscillation. A second waveguide with second ring resonator can receive the frequencies and optically synchronize the frequencies via optical frequency division to generate a low frequency signal. One or more heating elements can be connected to each ring resonator to tune the resonators and reduce noise associated with the low frequency signal.

公开(公告)号：US20240400786A1

公开(公告)日：2024-12-05

申请号：US18205437

申请日：2023-06-02

Applicant: International Business Machines Corporation ,  The Trustees of Columbia University in the City of New York

Inventor： Luis M. Campos ,  Dino Wu ,  James L. Hedrick ,  Nathaniel H. Park

IPC: C08J11/16

Abstract: Introduce into a reactor a polyurethane having a benzylic linkage. In one aspect, induce a chemical reduction through a reducing agent and a catalyst to depolymerize the polyurethane having the benzylic linkage. In another aspect, introduce hydrogen bromide into the reactor, and react the polyurethane with the hydrogen bromide to recover constituents of the polyurethane via acid-catalyzed bromine-substitution to cleave the benzylic linkage of the polyurethane.

公开(公告)号：US20240398780A1

公开(公告)日：2024-12-05

申请号：US18615735

申请日：2024-03-25

Applicant: Belite Bio, Inc ,  The Trustees Of Columbia University In The City Of New York

Inventor： Yu-Hsin Tom LIN ,  Cheng-Chi Irene WANG ,  Konstantin PETRUKHIN

IPC: A61K31/4545 ,  A61K9/00 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5365 ,  A61K31/5383 ,  A61P3/04 ,  A61P3/10

Abstract: Provided herein are heterocyclic derivative compounds and pharmaceutical compositions comprising said compounds that are useful for the treatment of retinal binding protein (RBP4) related diseases, such as obesity and the like.

公开(公告)号：US20240395418A1

公开(公告)日：2024-11-28

申请号：US18419923

申请日：2024-01-23

Applicant: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

Inventor： Gamze Gürsoy ,  Ahmed Elhussein

IPC: G16H50/70 ,  G06F16/22 ,  G06F16/23 ,  G06F16/245

Abstract: A method for practicing precision medicine comprising providing, to a blockchain platform, each of clinical data and genetic data, providing the blockchain platform, the blockchain platform having a first data structure comprising clinical data and a second data structure comprising genetic data, harmonizing the first and second data structures, creating at least one cohort based on the harmonized first and second data structures, and identifying at least one relationship between the clinical data and the genetic data in each of the at least one cohort.

公开(公告)号：US20240384325A1

公开(公告)日：2024-11-21

申请号：US18665401

申请日：2024-05-15

Applicant: California Institute of Technology ,  The Trustees of Columbia University in the City of New York

Inventor： Erica Wolin ,  James Guo ,  Mitchell Guttman ,  Marko Jovanovic

IPC: C12Q1/6804 ,  C12Q1/6806 ,  C12Q1/6834 ,  C12Q1/6869

Abstract: Aspects of the present disclosure generally relate to methods and compositions for detecting an association between a RNA binding protein and a RNA. Some aspects of the present disclosure relate to methods of generating an antibody-bead conjugate pool. Some aspects of the present disclosure relate to kits and compositions for performing the methods disclosed herein.

公开(公告)号：US20240382732A1

公开(公告)日：2024-11-21

申请号：US18784013

申请日：2024-07-25

Applicant: The Trustees of Columbia University in the City of New York

Inventor： Aykut AKSIT ,  Stephen LEONG ,  Anil K. LALWANI ,  Jeffrey W. KYSAR

IPC: A61M37/00 ,  A61M5/178

Abstract: A microneedle system is provided including a needle assembly having a microneedle with a longitudinal body with a diameter of about 50 microns to about 200 microns, the microneedle defining a sharpened tip and a proximal end thereof, the microneedle having first and second lumens extending therethrough, each of the first and second lumens having a distal openings located proximal to the sharpened tip and a proximal opening at a proximal end of the microneedle; a base having a distal end and a proximal end, the distal end of the base coupled to the proximal end of the microneedle and defining first and second passages in fluid communication with the first and second lumens; and a pair of tubes coupled to the base, each tube in fluid communication with a respective first and second passage of the base; a syringe pump; and circulation tubing connecting the syringe pump with the pair of tubes in the needle assembly.

公开(公告)号：US20240375041A1

公开(公告)日：2024-11-14

申请号：US18772960

申请日：2024-07-15

Applicant: Carbfix ,  University of Iceland ,  The Trustees of Columbia University In The City Of New York ,  Barnard College

Inventor： Bergur SIGFÚSSON ,  Edda Sif Pind ARADÓTTIR ,  Ingvi GUNNARSSON ,  Magnús Þór ARNARSON ,  Einar GUNNLAUGSSON ,  Hólmfriður SIGURDARDÓTTIR ,  Húni SIGHVATSSON ,  Sigurður Reynir GÍSLASON ,  Eric H. OELKERS ,  Kiflom G. MESFIN ,  Sandra Osk SNAEBJÖRNSDÓTTIR ,  Iwona M. GALECZKA ,  Domenik WOLFF-BOENISCH ,  Helgi A. ALFREDSSON ,  Porsteinn JÓNSSON ,  Andri STEFÁNSSON ,  Jürg MATTER ,  Martin STUTE ,  Deirdre Elizabeth CLARK ,  Martin Johannes VOIGT

IPC: B01D53/14 ,  B65G5/00 ,  E21B41/00 ,  E21B47/11

Abstract: A method and a system of abating carbon dioxide (CO2) and/or hydrogen sulfide (H2S) in a geological reservoir. Water is pumped or transferred from a water source to an injection well. The gasses are merged with the water under conditions where the hydraulic pressure of the water is less than the pressure of CO2 and/or H2S gas at the merging point. The water with CO2 and/or H2S gas bubbles is transferred further downwardly at a certain velocity higher than the upward flow velocity of said CO2 and/or H2S gas bubbles ensuring downward movement of gas bubbles resulting in full dissolution of said CO2 and/or H2S in the water due to elevating pressure.