公开(公告)号：US5795582A

公开(公告)日：1998-08-18

申请号：US597938

申请日：1996-02-07

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K39/145 ,  A61K39/39 ,  A61K9/00 ,  A61K47/48

CPC classification number: A61K39/39 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K2039/5252 ,  A61K2039/645 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234 ,  Y10S424/16

Abstract: A new method of adjuvanting a variety of materials has been developed. Starburst dendrimers, primarily poly(amidoamine) starburst dendrimers, can be used as an adjuvant for Influenza antigen and similar materials. Mid-Generation dendrimers are preferred and yield high antibody titer levels with reduced antigen dosage.

Abstract translation: 已经开发了一种佐剂各种材料的新方法。 Starburst树枝状大分子，主要是聚（酰胺胺）星爆树枝状大分子，可用作流感抗原和类似材料的佐剂。 中一代树枝状大分子是优选的，并且产生抗体滴度高的抗体，抗原剂量降低。

公开(公告)号：US5662957A

公开(公告)日：1997-09-02

申请号：US643171

申请日：1996-05-03

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A23D7/005 ,  A23D7/04 ,  A23K1/00 ,  A23K1/18 ,  A61K9/127

CPC classification number: A23D7/0053 ,  A23D7/04 ,  A23K40/30 ,  A23K50/80 ,  A61K9/1272 ,  Y10S514/938

Abstract: Disclosed is a new class of lipid vesicles, liposoils, which have high oil content, low water content, and protein. The liposoils are made using a combination of a surfactant and either dried egg yolk or dried whole egg as the wall material, oil, and an aqueous diluent. Unlike most lipid vesicles, the liposoils can be made with an aqueous diluent having high salinity; in fact, sea water is a preferred aqueous diluent. Liposoils have particular applicability as a food for marine environments, such as a food source for filter feeders such as oysters. Methods of making the liposoils is also disclosed.

Abstract translation: 公开了一类新型脂质囊泡，脂油脂，含油量高，含水量低，蛋白质含量高。 脂肪油是使用表面活性剂和干燥的蛋黄或干燥的全蛋作为壁材料，油和水性稀释剂的组合制成的。 与大多数脂质囊泡不同，脂质体可以用具有高盐度的水性稀释剂制成; 事实上，海水是优选的水性稀释剂。 脂质体作为海洋环境的食物具有特别的适用性，例如过滤饲料如牡蛎的食物来源。 还公开了制备脂质体的方法。

公开(公告)号：US5547677A

公开(公告)日：1996-08-20

申请号：US246868

申请日：1994-05-20

Applicant: D. Craig Wright

Inventor： D. Craig Wright

IPC: A61K9/127 ,  A61K31/14 ,  A61K31/23 ,  A61K45/06 ,  A61K7/40 ,  A61K9/107

CPC classification number: A61K45/06 ,  A61K31/14 ,  A61K31/23 ,  A61K9/1272

Abstract: An antimicrobial lipid-containing oil-in-water emulsion comprising an agent selected from the group consisting of glycerol monooleate, glycerol trioleate, glycerol monolaurate, and glycerol dilaurate as the primary lipid and a cationic halogen-containing compound having a C.sub.12 -C.sub.16 chain as a positive charge producing agent is disclosed. The antimicrobial emulsion can be used in the form of a pharmaceutical preparation to inhibit the growth of a wide variety of infectious pathogens.