公开(公告)号：US20060262313A1

公开(公告)日：2006-11-23

申请号：US11460932

申请日：2006-07-28

Applicant: Dar Bahatt ,  Jerry Cahill ,  Koichi Nishikida ,  Enrico Picozza ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

Inventor： Dar Bahatt ,  Jerry Cahill ,  Koichi Nishikida ,  Enrico Picozza ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

IPC: G01N21/55

CPC classification number: G01N21/7703 ,  G01N21/553

Abstract: An optical resonance analysis system comprising a sensor means (60) and an illumination means (400) for generating non-monochromatic illumination. The illumination means (400) further comprises a means for generating illumination at a plurality of angles, a lens system for projecting said illumination at said plurality of angles (390) and a dispersive device (380) for dispersing said illumination at each of said plurality of angles so that there is a correlation between said plurality of angles and the wavelengths of said illumination such that a resonance condition is generated on said sensor mean (60) for all wavelengths generated by said non-monochromatic source simultaneously. The analysis system also comprises a detection means (90) for detecting the reflected or transmitted illumination. Another embodiment comprises an anamorphic imaging means (120).

Abstract translation: 一种光学共振分析系统，包括传感器装置（60）和用于产生非单色照明的照明装置（400）。 照明装置（400）还包括用于以多个角度产生照明的装置，用于以所述多个角度（390）投射所述照明的透镜系统和用于将所述照明分散在所述多个角度的分散装置（380） 的角度，使得在所述多个角度和所述照明的波长之间存在相关性，使得对于由所述非单色源同时产生的所有波长的所述传感器平均值（60）产生共振条件。 分析系统还包括用于检测反射或透射照明的检测装置（90）。 另一实施例包括变形成像装置（120）。

公开(公告)号：US6033880A

公开(公告)日：2000-03-07

申请号：US27989

申请日：1998-02-23

Applicant: Lawrence A. Haff ,  Enrico Picozza ,  Will Bloch ,  Robert Ragusa ,  Joseph DiCesare ,  David Tracy ,  Paul Saviano ,  Timothy M. Woudenberg ,  Richard W. Noreiks

Inventor： Lawrence A. Haff ,  Enrico Picozza ,  Will Bloch ,  Robert Ragusa ,  Joseph DiCesare ,  David Tracy ,  Paul Saviano ,  Timothy M. Woudenberg ,  Richard W. Noreiks

IPC: C12N15/09 ,  B01J19/00 ,  B01L7/00 ,  C12M1/00 ,  C12Q1/68 ,  C40B40/06 ,  C40B60/14 ,  G01N35/00 ,  C12P19/34

CPC classification number: B01L7/525 ,  B01J19/0046 ,  B01L7/52 ,  B01L9/065 ,  B01J2219/00495 ,  B01J2219/00722 ,  B01L2300/1883 ,  C12Q1/686 ,  C40B40/06 ,  C40B60/14 ,  G01N2035/00237 ,  Y10T436/116664

Abstract: Apparatus and method for performing a nucleic acid amplification reaction and preferably a polymerase chain reaction (PCR) in a reaction mixture in at least one capillary tube. Several different embodiments are disclosed. One embodiment cycles a sample through a capillary tube loop passing through two thermostatted fluid baths. Another embodiment has the capillary tube routed alternatingly between two heat exchangers to that the sample makes only one pass through the tube. Other embodiments maintain the heat exchangers stationary and translate the samples between them. Still further embodiments maintain the samples stationary and either automatically translate or rotate the heat exchangers past the samples contained within the capillary tubes to perform the thermal cycles necessary for the amplification reaction.

Abstract translation: 用于在至少一个毛细管中的反应混合物中进行核酸扩增反应和优选聚合酶链式反应（PCR）的装置和方法。 公开了几个不同的实施例。 一个实施例通过穿过两个恒温流体浴的毛细管回路循环样品。 另一个实施例中，毛细管在两个热交换器之间交替布置，使得样品仅穿过管中一次。 其他实施例保持热交换器平稳，并在它们之间平移样品。 另外的实施例保持样品静止，并且自动地将热交换器平移或旋转通过毛细管内包含的样品，以进行扩增反应所需的热循环。

公开(公告)号：US5428558A

公开(公告)日：1995-06-27

申请号：US168800

申请日：1993-12-17

Applicant: Jerry E. Cahill ,  Alan M. Ganz ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

Inventor： Jerry E. Cahill ,  Alan M. Ganz ,  Paul Saviano ,  David Tracy ,  Yongdong Wang

IPC: G01J3/02 ,  G01J3/28 ,  G01N21/27 ,  G01D18/00

CPC classification number: G01J3/28 ,  G01J2003/2866

Abstract: A method and apparatus are provided for correction of spectra for stray radiation in a spectrometric instrument, involving a sequence of steps as follows. Spectral patterns are obtained with the instrument initially for monochromatic radiation at a plurality of selected calibration wavelengths. By computer program, the peak profile at the calibration wavelength in each pattern is replaced with a substitute based on the remaining pattern. The resulting data are interpolated to effect values denoted "stray proportions" for the ordered wavelengths of the instrument. Spectral data at each ordered wavelength are obtained with the instrument for a sample, and multiplied in the computer program by stray proportions for corresponding wavelengths to effect further sets of values denoted "stray portions" that are identified to the ordered wavelengths. Each set is identified to one of the wavelength increments of the instrument across the spectral range. In each set, the stray portions for the ordered wavelengths are summed. The total for each wavelength increment is subtracted from the original sample data for the increment to effect spectral data corrected for stray.

Abstract translation: 提供了一种用于校正光谱仪器中杂散辐射的光谱的方法和装置，涉及如下的一系列步骤。 在多个选定的校准波长下，仪器最初用于单色辐射获得光谱图案。 通过计算机程序，每个模式中校准波长处的峰值曲线被替换为基于剩余模式的替代。 内插所得数据以对仪器的有序波长表示为“杂散比”的值。 用样品的仪器获得每个有序波长的光谱数据，并在计算机程序中乘以相应波长的杂散比例，以实现被标识为有序波长的标记为“杂散部分”的另外一组值。 每个组被识别为跨越光谱范围的仪器的波长增量之一。 在每组中，将有序波长的杂散部分相加。 从原始采样数据中减去每个波长增量的总和，以增加修正为杂散的光谱数据。