公开(公告)号：US12077808B2

公开(公告)日：2024-09-03

申请号：US17735509

申请日：2022-05-03

Applicant: The University of North Carolina at Chapel Hill

Inventor： John Michael Ramsey ,  William Henley ,  Emily Oblath

IPC: C12Q1/68 ,  B01L3/00 ,  B01L7/00 ,  C12Q1/6823 ,  C12Q1/6853 ,  C12Q1/686 ,  G01N35/00

CPC classification number: C12Q1/6823 ,  B01L3/502761 ,  B01L7/52 ,  C12Q1/6853 ,  C12Q1/686 ,  B01J2219/00317 ,  B01J2219/00454 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00554 ,  B01J2219/00576 ,  B01J2219/00619 ,  B01L3/5027 ,  B01L3/502715 ,  B01L2200/16 ,  B01L2300/0636 ,  B01L2300/0829 ,  B01L2300/0864 ,  G01N2035/00158 ,  C12Q1/6853 ,  C12Q2563/149 ,  C12Q2565/629 ,  C12Q1/6823 ,  C12Q2537/143 ,  C12Q2563/149 ,  C12Q2565/537 ,  C12Q2565/629

Abstract: A microfluidic device includes a plurality of reaction wells; and a plurality of solid supports, and each of the solid supports has a reagent attached thereto. The reagent is attached to the solid support via a labile reagent/support bond such that the reagent is configured to be cleaved from the support via a cleaving operation.

公开(公告)号：US20240139701A1

公开(公告)日：2024-05-02

申请号：US18279657

申请日：2022-03-22

Applicant: EGI Tech (Qing Dao) Co., Limited

Inventor： Yiwen Ouyang ,  Sz-Chin Lin ,  Cheng Zhong

IPC: B01J19/00

CPC classification number: B01J19/0046 ,  B01J2219/00326 ,  B01J2219/00351 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/0059 ,  B01J2219/00689 ,  B01J2219/00698 ,  B01J2219/00702

Abstract: A parallel multi-step bio-reaction system(10) comprising: (a) a substrate arrangement(12) comprising a plurality of bio-reaction substrate holders(18) configured to hold a plurality of bio-reaction substrates(20); (b) a well arrangement(14) comprising a plurality of fluidic wells(22), the fluidic wells(22) corresponding to a plurality of steps of a multi-step bio-reaction; (c) an actuator(16) configured to: (i) move either the substrate arrangement(12) or the well arrangement(14) relative to the other of the substrate arrangement(12) or the well arrangement(14) to change the alignment of the bio-reaction substrates(20) as a group relative to the fluidic wells(22) as a group; and (ii) bring the bio-reaction substrates(20) into and out of contact with fluids in the fluidic wells(22).

公开(公告)号：US11786882B2

公开(公告)日：2023-10-17

申请号：US18245331

申请日：2022-04-27

Applicant: SOUTHEAST UNIVERSITY

Inventor： Lunbo Duan ,  Hetong Gao ,  Zhenkun Sun ,  Tianxin Li

IPC: B01J19/08 ,  B82Y40/00 ,  B01J19/00

CPC classification number: B01J19/087 ,  B01J19/0033 ,  B82Y40/00 ,  B01J2219/00495 ,  B01J2219/085

Abstract: A device for magnetic field-assisted simulation of zero-microgravity flame synthesis of nanoparticles includes a gradient magnetic field device, a combustor and a product collection device. The gradient magnetic field device is composed of two magnetic field devices arranged face to face. The combustor is located between the two magnetic field devices. The outlet of the combustor is vertically upward. The position is below the magnetic field center of the gradient magnetic field device. The body force acting on the flame and surrounding magnetic species thereof by the gradient magnetic field device counteracts the gravitational buoyancy lift effect, so that flame synthesis is carried out under a simulated zero/microgravity flame to prepare the nanoparticles. The device is able to use a gradient magnetic field to simulate the zero/microgravity flame on the ground to synthesize the nanoparticles under special flame characteristics, with reduced flame disturbance, improved stability, and no overheated region.

公开(公告)号：US20180348103A1

公开(公告)日：2018-12-06

申请号：US16102242

申请日：2018-08-13

Applicant: Lee H. Angros

Inventor： Lee H. Angros

IPC: G01N1/31 ,  B01L3/02 ,  G01N1/44 ,  G01N35/00 ,  B01L7/00

CPC classification number: G01N1/312 ,  B01J2219/0036 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00533 ,  B01J2219/00659 ,  B01L3/0293 ,  B01L7/54 ,  B01L2200/04 ,  B01L2200/16 ,  B01L2300/0822 ,  B01L2300/14 ,  B01L2400/0478 ,  G01N1/44 ,  G01N35/00029 ,  G01N2035/00039 ,  G01N2035/00138 ,  G01N2035/00168 ,  G01N2035/00346 ,  Y10T436/11 ,  Y10T436/110833 ,  Y10T436/111666 ,  Y10T436/112499 ,  Y10T436/114165

Abstract: An apparatus for spreading at least one reagent on at least a portion of a microscope slide includes a spreading device positionable in association with a microscope slide in a way that the spreading device defines a gap between the spreading device and the microscope slide and in a way that the spreading device and the microscope slide are movable relative to one another to spread at least one reagent on at least a portion of the microscope. The spreading device has a reservoir in which the at least one reagent is stored in a way that the at least one reagent is dischargeable from the reservoir onto the microscope slide when the spreading device is positioned in association with the microscope slide.

公开(公告)号：US20180231536A1

公开(公告)日：2018-08-16

申请号：US15952958

申请日：2018-04-13

Applicant: Theranos IP Company, LLC

Inventor： Tammy BURD ,  Ian GIBBONS ,  Elizabeth A. HOLMES ,  Gary FRENZEL ,  Anthony Joseph NUGENT

IPC: G01N33/53 ,  G01N35/10 ,  A61B5/15 ,  G01N35/02 ,  G01N35/00 ,  G01N33/94 ,  G01N33/68 ,  G01N33/574 ,  G01N33/569 ,  G01N33/543 ,  G01N1/38 ,  B01L9/00 ,  B01L7/00 ,  B01L3/00 ,  B01L3/02 ,  B01J19/00 ,  A61B5/151 ,  A61B10/00 ,  A61B10/02

CPC classification number: G01N33/5304 ,  A61B5/15 ,  A61B5/150755 ,  A61B5/151 ,  A61B10/0038 ,  A61B10/0045 ,  A61B10/0051 ,  A61B10/0058 ,  A61B10/007 ,  A61B10/02 ,  A61B2010/0074 ,  A61B2010/0077 ,  B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00292 ,  B01J2219/00315 ,  B01J2219/00369 ,  B01J2219/00371 ,  B01J2219/00385 ,  B01J2219/00466 ,  B01J2219/00495 ,  B01J2219/005 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01L3/021 ,  B01L3/0262 ,  B01L3/5025 ,  B01L3/527 ,  B01L7/52 ,  B01L7/5255 ,  B01L9/543 ,  B01L2200/04 ,  B01L2200/0689 ,  B01L2200/141 ,  B01L2200/148 ,  B01L2300/0654 ,  B01L2300/0829 ,  B01L2300/1805 ,  B01L2400/043 ,  G01N1/38 ,  G01N33/5302 ,  G01N33/54326 ,  G01N33/54366 ,  G01N33/54386 ,  G01N33/56966 ,  G01N33/57484 ,  G01N33/6803 ,  G01N33/94 ,  G01N35/00732 ,  G01N35/00871 ,  G01N35/028 ,  G01N35/10 ,  G01N35/1065 ,  G01N35/1074 ,  G01N2035/00237 ,  G01N2035/00851 ,  G01N2035/00881 ,  G01N2035/0097 ,  G01N2035/1032 ,  G01N2035/1034 ,  G01N2035/1048 ,  G01N2333/4737 ,  G01N2333/475 ,  G01N2333/71 ,  G01N2333/912 ,  G01N2333/91205 ,  G01N2333/9129 ,  G01N2800/26 ,  G01N2800/60 ,  G16H10/40 ,  Y10T29/49826 ,  Y10T436/25375

Abstract: The present invention provides devices and systems for use at the point of care. The methods devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device are modular to allow for flexibility and robustness of use with the disclosed methods for a variety of medical applications.

公开(公告)号：US20180209743A1

公开(公告)日：2018-07-26

申请号：US15934763

申请日：2018-03-23

Applicant: BayoTech, Inc.

Inventor： Milton Edward Vernon

IPC: F28D7/10 ,  H01M8/0612 ,  C05C9/00 ,  C07C273/04 ,  C01C1/04 ,  C01B3/48 ,  B01J19/00 ,  B01J15/00 ,  B01J7/00 ,  C01B3/38

CPC classification number: F28D7/103 ,  B01J8/008 ,  B01J8/0257 ,  B01J8/0278 ,  B01J8/0285 ,  B01J8/0465 ,  B01J12/007 ,  B01J2208/00212 ,  B01J2208/00309 ,  B01J2208/0053 ,  B01J2208/025 ,  B01J2219/00495 ,  B01J2219/0072 ,  B01J2219/00745 ,  C01B3/384 ,  C01B3/48 ,  C01B2203/0233 ,  C01B2203/0283 ,  C01B2203/068 ,  C01B2203/0811 ,  C01B2203/1241 ,  C01B2203/82 ,  C01C1/0417 ,  C01C1/0482 ,  C05C9/00 ,  C07C273/04 ,  F28D7/12 ,  F28D2021/0022 ,  F28F1/122 ,  H01M8/0618 ,  H01M2250/10 ,  Y02B90/14 ,  Y02P20/124 ,  Y02P20/142 ,  Y02P20/52

Abstract: Disclosed is a technology based upon the nesting of tubes to provide chemical reactors or chemical reactors with built in heat exchanger. As a chemical reactor, the technology provides the ability to manage the temperature within a process flow for improved performance, control the location of reactions for corrosion control, or implement multiple process steps within the same piece of equipment. As a chemical reactor with built in heat exchanger, the technology can provide large surface areas per unit volume and large heat transfer coefficients. The technology can recover the thermal energy from the product flow to heat the reactant flow to the reactant temperature, significantly reducing the energy needs for accomplishment of a process.

公开(公告)号：US09938145B2

公开(公告)日：2018-04-10

申请号：US15166735

申请日：2016-05-27

Applicant: Shrikar Chakravarti ,  Raymond Francis Drnevich ,  Minish M. Shah ,  Ines C. Stuckert

Inventor： Shrikar Chakravarti ,  Raymond Francis Drnevich ,  Minish M. Shah ,  Ines C. Stuckert

IPC: C01B3/26 ,  C01B3/38 ,  C01B13/02 ,  B01J8/04 ,  B01J8/00

CPC classification number: C01B3/386 ,  B01J8/009 ,  B01J8/0457 ,  B01J8/0496 ,  B01J2208/0053 ,  B01J2219/00006 ,  B01J2219/00495 ,  B01J2219/00745 ,  C01B3/26 ,  C01B3/382 ,  C01B3/384 ,  C01B13/0251 ,  C01B2203/0233 ,  C01B2203/0244 ,  C01B2203/0261 ,  C01B2203/04 ,  C01B2203/0495 ,  C01B2203/0833 ,  C01B2203/0838 ,  C01B2203/0883 ,  C01B2203/1205 ,  C01B2203/1235 ,  C01B2203/127 ,  C01B2203/142 ,  C01B2203/80

Abstract: A method and system for producing a synthesis gas in an oxygen transport membrane based reforming system is disclosed that carries out an air heated pre-reforming process, a primary reforming process, a secondary reforming process.

公开(公告)号：US09757706B2

公开(公告)日：2017-09-12

申请号：US14402943

申请日：2013-05-24

Applicant: The University Court of the University of Glasgow

Inventor： Leroy Cronin

IPC: B01J19/00 ,  C40B50/04 ,  C40B60/08

CPC classification number: B01J19/0046 ,  B01J2219/00283 ,  B01J2219/00286 ,  B01J2219/00353 ,  B01J2219/00479 ,  B01J2219/00495 ,  B01J2219/0059 ,  B01J2219/00599 ,  B01J2219/00689 ,  B01J2219/00695 ,  B01J2219/00698 ,  B01J2219/007 ,  B01J2219/00702 ,  B01J2219/00704 ,  B01J2219/00738 ,  B01J2219/00747 ,  B01J2219/00756 ,  C40B50/04 ,  C40B60/08

Abstract: The invention provides a method for preparing a compound or a product having one or more characteristics that meet or exceed a user specification, the process comprising the step of selecting a first combination of chemical inputs, optionally together with physical inputs, and supplying those inputs to a reaction space, thereby to generate a first product; analyzing one or more characteristics of the product generated; comparing the one or more characteristics against a user specification; using a genetic algorithm selecting a second combination of chemical inputs, optionally together with physical inputs, wherein the second combination differs from the first combination, and supplying those inputs to the reaction space, thereby to generate a second product; analyzing one or more characteristics of the second product generated; comparing the one or more characteristics generated against the user specification; repeating the selecting and analyzing steps for further individual combinations of chemical and/or physical inputs, to provide an array of products wherein the flow chemistry system operates continuously to provide the first, second and further products, thereby to identify one or more products meeting or exceeding the user specification.

公开(公告)号：US09708553B2

公开(公告)日：2017-07-18

申请号：US14236994

申请日：2012-07-30

Applicant: Josef Find ,  Alfred Haas ,  Armin Brenner

Inventor： Josef Find ,  Alfred Haas ,  Armin Brenner

IPC: C10G65/14 ,  C10G45/22 ,  C10G29/02 ,  B01J19/00 ,  C40B30/08 ,  C40B60/12

CPC classification number: C10G65/14 ,  B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00306 ,  B01J2219/00389 ,  B01J2219/00418 ,  B01J2219/00477 ,  B01J2219/00495 ,  B01J2219/00585 ,  B01J2219/00698 ,  B01J2219/00707 ,  B01J2219/0072 ,  B01J2219/00747 ,  C10G29/02 ,  C10G45/22 ,  C40B30/08 ,  C40B60/12

Abstract: The present invention relates to a process for handling product fluid streams which are obtained in the catalytic hydrogenation of liquid feeds in laboratory catalysis apparatuses. The liquid feeds are preferably hydrocarbons comprising sulfur- and nitrogen-comprising compounds as impurities. The hydrogenation serves to convert the impurities into hydrogen sulfide and ammonia which in this form can be readily separated off from the other constituents of the liquid feed. The product fluid streams are contacted with an inert gas stream, with the flow rate of the inert gas being a multiple of the flow rate of the product fluid stream. The formation of deposits in lines of the region on the outlet side of the reaction space can be effectively prevented by means of the process of the invention.

公开(公告)号：US09623394B2

公开(公告)日：2017-04-18

申请号：US13983449

申请日：2012-02-03

Applicant: Günter Roth ,  Jürgen Burger

Inventor： Günter Roth ,  Jürgen Burger

IPC: B01J19/00 ,  B01L3/00 ,  B82Y30/00

CPC classification number: B01J19/0046 ,  B01J2219/00286 ,  B01J2219/00337 ,  B01J2219/00495 ,  B01J2219/00529 ,  B01J2219/00533 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/00608 ,  B01J2219/0061 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/00675 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/508 ,  B01L2200/0689 ,  B01L2300/0636 ,  B01L2300/0822 ,  B82Y30/00

Abstract: The invention relates to a device and a method for the generation of molecular microarrays. The invention relates therefore to a universal approach for the generation of protein microarrays, DNA microarrays and RNA microarrays (in general nucleic acid microarrays), by production of an output molecule from a template molecule microarray via enzymatic or chemical processes and transfer of the output molecule onto the desired molecular microarray.