公开(公告)号：US20080139577A1

公开(公告)日：2008-06-12

申请号：US11827467

申请日：2007-07-12

Applicant: Charles Z. Ding ,  In Ho Kim ,  Jiancheng Wang ,  Zhenkun Ma ,  Yafei Jin ,  Keith D. Combrink ,  Genliang Lu ,  A. Simon Lynch

Inventor： Charles Z. Ding ,  In Ho Kim ,  Jiancheng Wang ,  Zhenkun Ma ,  Yafei Jin ,  Keith D. Combrink ,  Genliang Lu ,  A. Simon Lynch

IPC: A61K31/497 ,  A61P31/04 ,  C07D267/00

CPC classification number: C07D498/18 ,  C07D498/08 ,  C07D498/22 ,  C07D519/00

Abstract: Substituted rifamycin derivatives in which a nitroimidazole, nitrothiazole or nitrofuran pharmacophore is covalently bonded to a rifamycin, methods of using the rifamycin derivatives, and pharmaceutical compositions containing the rifamycin derivatives are disclosed. Methods of synthesizing these substituted rifamycin derivatives are also disclosed. The rifamycin derivatives possess antibacterial activity, and are effective against a number of human and veterinary pathogens in the treatment of bacterial diseases.

Abstract translation: 公开了其中硝基咪唑，硝基噻唑或硝基呋喃药效团与利福霉素共价结合的取代的利福霉素衍生物，使用利福霉素衍生物的方法和含有利福霉素衍生物的药物组合物。 还公开了合成这些取代的利福霉素衍生物的方法。 利福霉素衍生物具有抗菌活性，并且在治疗细菌性疾病中对许多人和兽医病原体有效。