公开(公告)号：US20150374667A1

公开(公告)日：2015-12-31

申请号：US14626126

申请日：2015-02-19

Applicant: Howard University

Inventor： Harpal S. Mangat ,  Pradeep K. Karla

IPC: A61K31/4178 ,  A61K38/05 ,  A61K45/06

CPC classification number: A61K31/4178 ,  A61K31/13 ,  A61K31/355 ,  A61K31/40 ,  A61K31/5513 ,  A61K31/5517 ,  A61K31/59 ,  A61K31/765 ,  A61K38/05 ,  A61K45/06 ,  A62B17/00 ,  C07D405/12 ,  Y10T428/2982 ,  A61K2300/00

Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.

Abstract translation: 提供了治疗缺血性神经元再灌注损伤的方法和组合物。 该组合物可以包括化合物，其是丹曲林和FMOC-缬氨酸残基的组合。 该组合物可用于提供比迄今为止与丹曲林一样经历的更快和更高的CNS渗透。 在另一种形式中，丹曲林可以配制成前体药物，前体药物等。

公开(公告)号：US20150118335A1

公开(公告)日：2015-04-30

申请号：US14591780

申请日：2015-01-07

Applicant: Howard University

Inventor： Evaristus A. Nwulia

IPC: A61K36/53 ,  A61M16/20 ,  A61M16/06 ,  A61M16/12 ,  A61K9/00 ,  A61M16/00

CPC classification number: A61K36/53 ,  A61K9/0043 ,  A61K9/007 ,  A61K36/54 ,  A61K36/752 ,  A61M15/0085 ,  A61M16/0666 ,  A61M16/0672 ,  A61M16/12 ,  A61M16/122 ,  A61M16/16 ,  A61M16/162 ,  A61M16/208 ,  A61M21/00 ,  A61M2016/003 ,  A61M2021/0016 ,  A61M2202/0208 ,  A61M2205/8206 ,  A61M2205/8237

Abstract: A method, apparatus and kit have been discovered which utilize pulsed odorants, drugs, medicaments, and combinations thereof to treat diseases, symptoms of diseases and the like. In one form, the pulsed odorants, drugs, medicaments, and combinations thereof can be used to regenerate the connections of the neurons of the brain and central nervous system in the treatment of symptoms of such person afflicted with neuro-disorders, such as caused by disease or trauma.

Abstract translation: 已经发现利用脉冲气味剂，药物，药物及其组合来治疗疾病，疾病症状等的方法，装置和试剂盒。 在一种形式中，可以使用脉冲气味剂，药物，药物及其组合来再生脑和中枢神经系统的神经元的连接，以治疗患有神经障碍的人的症状，例如由 疾病或创伤。

公开(公告)号：US08993512B2

公开(公告)日：2015-03-31

申请号：US14273343

申请日：2014-05-08

Applicant: Howard University

Inventor： Harpal S. Mangat ,  Pradeep K. Karla

IPC: A61K38/00 ,  A61K47/00 ,  A61K31/4178 ,  C07D405/12 ,  A61K45/06 ,  A61K38/05 ,  A61K31/13 ,  A61K31/40 ,  A61K31/5513 ,  A61K31/5517

CPC classification number: A61K31/4178 ,  A61K31/13 ,  A61K31/355 ,  A61K31/40 ,  A61K31/5513 ,  A61K31/5517 ,  A61K31/59 ,  A61K31/765 ,  A61K38/05 ,  A61K45/06 ,  A62B17/00 ,  C07D405/12 ,  Y10T428/2982 ,  A61K2300/00

Abstract: A method and composition for the treatment of ischemic neuronal reperfusion injury are provided. The composition can include a compound which is a combination of dantrolene and a residue of FMOC-valine. This composition can be used to provide a faster and higher CNS penetration than heretofore experienced with dantrolene. In another form, dantrolene may be formulated as a pro-drug, a pro-pro-drug and the like.

Abstract translation: 提供了治疗缺血性神经元再灌注损伤的方法和组合物。 该组合物可以包括化合物，其是丹曲林和FMOC-缬氨酸残基的组合。 该组合物可用于提供比迄今为止与丹曲林一样经历的更快和更高的CNS渗透。 在另一种形式中，丹曲林可以配制成前体药物，前体药物等。

公开(公告)号：US20140134116A1

公开(公告)日：2014-05-15

申请号：US14075230

申请日：2013-11-08

Applicant: Colgate-Palmolive Company ,  Howard University

Inventor： Tongxin Wang ,  Yanda Lei ,  James W. Mitchell ,  Lynette Zaidel ,  Jianhong Qiu ,  Mahmoud Hassan

IPC: A61K8/90 ,  A61Q11/00

CPC classification number: A61K8/90 ,  A61K8/21 ,  A61Q11/00 ,  C08F293/005

Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same are also described.

Abstract translation: 这里描述的是具有疏水性嵌段和亲水性嵌段的嵌段共聚物，该嵌段共聚物有效结合硬组织的表面; 还描述了包含它们的组合物，以及制备和使用它们的方法。

公开(公告)号：US20140045741A1

公开(公告)日：2014-02-13

申请号：US14059035

申请日：2013-10-21

Applicant: Howard University

Inventor： Pradeep K. Karla ,  Harpal S. Mangat

IPC: A61K38/13

CPC classification number: A61K38/13 ,  A61K9/0048 ,  A61K31/496 ,  A61K31/53 ,  A61K31/546 ,  A61K31/573 ,  A61K38/14 ,  A61K2300/00

Abstract: Methods and compositions are provided for treating an ocular disease in a subject in need thereof by increasing the bioavailability of a drug in the subject's eye. In one aspect, the ocular disease is at least one of diabetic retinopathy, macular degeneration, endopthalmitis, glaucoma, cataracts, ocular herpes. The methods and compositions provided herein include an efflux transporter inhibitor and a drug effective for treating the ocular disease. The efflux transporter inhibitor is effective to reduce the efflux of the drug through at least one of P-glycoprotein (Pgp), breast cancer resistant protein (BCRP), and multidrug resistant associated protein 1-9 (MRP1-9).

Abstract translation: 提供了通过增加受试者眼睛中药物的生物利用度来治疗有需要的受试者的眼部疾病的方法和组合物。 一方面，眼部疾病是糖尿病性视网膜病变，黄斑变性，内耳炎，青光眼，白内障，眼疱疹中的至少一种。 本文提供的方法和组合物包括外排转运蛋白抑制剂和有效治疗眼部疾病的药物。 流出转运蛋白抑制剂通过P-糖蛋白（Pgp），乳腺癌耐药蛋白（BCRP）和多药耐药相关蛋白1-9（MRP1-9）中的至少一种有效减少药物的流出。

公开(公告)号：US12238197B2

公开(公告)日：2025-02-25

申请号：US17057950

申请日：2019-05-24

Applicant: Howard University

Inventor： Mamadou Ibra Wade

IPC: H04L9/00 ,  H04L9/30 ,  H04L9/14

Abstract: Encryption of an image is achieved through application of a homomorphic encryption function to produce cipher images for each image. Encryption is performed individually on sub-values of a pixel's intensity value, wherein the pixel's intensity value can be described as a sum of the smaller numerical sub-values. The encrypted values for each sub-value form encrypted images that can be transferred or stored on insecure media. Separate encryption approaches can be applied to individual sets of the numerical sub-values to improve security.

公开(公告)号：US20240216328A1

公开(公告)日：2024-07-04

申请号：US18490008

申请日：2023-10-19

Applicant: HOWARD UNIVERSITY

Inventor： Simeon Kolawole ADESINA

IPC: A61K31/366 ,  A61K9/51 ,  A61K31/337 ,  A61K38/00 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20

CPC classification number: A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00

Abstract: Disclosed are bruceolides for the treatment of cancer, and oilier diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.

公开(公告)号：US11826344B2

公开(公告)日：2023-11-28

申请号：US15775986

申请日：2016-11-18

Applicant: HOWARD UNIVERSITY

Inventor： Simeon Kolawole Adesina

IPC: A61K31/366 ,  A61K31/337 ,  C07D493/20 ,  A61K47/64 ,  A61P35/00 ,  A61K38/00 ,  A61K9/51

CPC classification number: A61K31/366 ,  A61K9/5146 ,  A61K9/5184 ,  A61K31/337 ,  A61K47/64 ,  A61P35/00 ,  C07D493/20 ,  A61K38/00 ,  A61K31/337 ,  A61K2300/00 ,  A61K31/366 ,  A61K2300/00

Abstract: Disclosed are bruceolides for the treatment of cancer, and other diseases, selectively targeting unwanted cells. The disclosed bruceolides may include a site specific cleavable moiety inhibiting the chemotoxic activity until cleaved, i.e., removed, within and/or near a cancer to be treated. As to facilitate selective delivery to cancer tumors, the disclosed bruceolides may be loaded into, attached to or otherwise carried by nanoparticles.

公开(公告)号：US11780833B2

公开(公告)日：2023-10-10

申请号：US16045254

申请日：2018-07-25

Applicant: HOWARD UNIVERSITY

Inventor： Oladapo Bakare ,  Samuel Ray Denmeade ,  Emmanuel S. Akinboye

IPC: C07K7/06 ,  C07D455/08 ,  C07D401/06

CPC classification number: C07D455/08 ,  C07D401/06 ,  C07K7/06

Abstract: Compounds are provided herein which are emetine derivatives that can be used as prodrugs which selectively undergo activation to release emetine in specific cellular conditions. In one aspect, a blocking group is incorporated onto the emetine molecule by the derivization of the N2′-position with moieties that can be selectively removed by hydrolysis in the cancer/tumor microenvironment. Such compounds are less cytotoxic than emetine and are substantially inactive in non-cancerous cells. In one aspect, the compounds described herein can be used for the treatment of metastatic and non-metastatic cancers, including, for example, breast cancer, prostate cancer, lung cancer, and leukemia.

公开(公告)号：US20230312669A1

公开(公告)日：2023-10-05

申请号：US18173264

申请日：2023-02-23

Applicant: Howard University

Inventor： Shaolei Teng ,  Qiyi Tang

IPC: C07K14/705 ,  A61P31/14

CPC classification number: C07K14/705 ,  A61P31/14

Abstract: The present disclosure provides novel computational methods for identifying potential therapeutic peptides as antivirals, and methods of using viral receptor-derived peptides as antivirals. Further, the present disclosure provides methods of using angiotensin converting enzyme 2 (ACE2)-derived peptides as therapeutic treatments for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-caused coronavirus disease 2019 (COVID-19).