公开(公告)号：US20120076380A1

公开(公告)日：2012-03-29

申请号：US13210497

申请日：2011-08-16

Applicant: Jens Gühring ,  Marie-Pierre Jolly ,  Hui Xue

Inventor： Jens Gühring ,  Marie-Pierre Jolly ,  Hui Xue

IPC: G06K9/00

CPC classification number: G01R33/56316 ,  A61B5/0263 ,  A61B5/055 ,  G01R33/5608

Abstract: A method for correcting the background phase in magnetic resonance phase contrast flow images includes providing a time series of velocity encoded magnetic resonance images of a patient, where the time series of velocity encoded images comprises for each time point a phase contrast image where a pixel intensity is proportional to a flow velocity, measuring a change of intensity for each pixel over the time series of phase contrast images, identifying pixels with a low measure of temporal change as stationary pixels, and calculating a correction field for the stationary pixels, where the correction field represents a background phase to be subtracted from the phase contrast image.

Abstract translation: 用于校正磁共振相位对比流图像中的背景相位的方法包括提供患者的速度编码的磁共振图像的时间序列，其中速度编码图像的时间序列包括每个时间点的像素强度 与流速成比例，测量在相位对比图像的时间序列上的每个像素的强度变化，将以时间变化的低度量度的像素识别为静止像素，以及计算用于静止像素的校正场，其中校正 场表示从相位差图像中减去的背景相位。

公开(公告)号：US09129424B2

公开(公告)日：2015-09-08

申请号：US13864716

申请日：2013-04-17

Applicant: Hui Xue ,  Peter Kellman ,  Andreas Greiser

Inventor： Hui Xue ,  Peter Kellman ,  Andreas Greiser

IPC: G06K9/00 ,  G06T11/00 ,  G01R33/50 ,  G01R33/565

CPC classification number: G06T11/003 ,  G01R33/50 ,  G01R33/56509

Abstract: Phase sensitive T1 mapping is provided in magnetic resonance (MR). The phase from samples of a modified Look-Locker inversion recovery sequence may be used to normalize contrast, allowing for accurate motion registration without extra information acquisition. The sign may be estimated, allowing T1 mapping with a single application of a non-linear fit.

Abstract translation: 在磁共振（MR）中提供相敏T1映射。 来自改进的Look-Locker反转恢复序列的样本的相位可以用于对比度的归一化，允许精确的运动注册，而不需要额外的信息获取。 可以估计符号，允许使用非线性拟合的单个应用的T1映射。

公开(公告)号：US09053386B2

公开(公告)日：2015-06-09

申请号：US13509059

申请日：2012-01-18

Applicant: Hui Xue

Inventor： Hui Xue

IPC: G06K9/62 ,  G06F17/30

CPC classification number: G06K9/6202 ,  G06F17/30259 ,  G06K9/4604 ,  G06K9/4642 ,  G06K9/6212 ,  G06K9/6215

Abstract: A user may submit an image and request from a server one or more images that are similar to the submitted image. The server may generate an image signature based on the content of the submitted image. The server may conduct a Hash operation to the image signature to generate one or more Hash values. These Hash values may be used to identify one or more candidate images similar to the image in a Hash table. These candidate images may be sorted and outputted to the user based on similarity. The similarity between each of the candidate images and the image may be determined using at least one of Hamming distance or Euclidean distance.

Abstract translation: 用户可以从服务器提交与提交的图像相似的一个或多个图像的图像和请求。 服务器可以基于提交的图像的内容生成图像签名。 服务器可以对图像签名进行哈希操作，以生成一个或多个哈希值。 这些哈希值可用于识别与哈希表中的图像类似的一个或多个候选图像。 这些候选图像可以基于相似性被分类并输出给用户。 可以使用汉明距离或欧氏距离中的至少一个来确定每个候选图像和图像之间的相似度。

公开(公告)号：US20130301935A1

公开(公告)日：2013-11-14

申请号：US13509059

申请日：2012-01-18

Applicant: Hui Xue

Inventor： Hui Xue

IPC: G06K9/62

CPC classification number: G06K9/6202 ,  G06F17/30259 ,  G06K9/4604 ,  G06K9/4642 ,  G06K9/6212 ,  G06K9/6215

Abstract: A user may submit an image and request from a server one or more images that are similar to the submitted image. The server may generate an image signature based on the content of the submitted image. The server may conduct a Hash operation to the image signature to generate one or more Hash values. These Hash values may be used to identify one or more candidate images similar to the image in a Hash table. These candidate images may be sorted and outputted to the user based on similarity. The similarity between each of the candidate images and the image may be determined using at least one of Hamming distance or Euclidean distance.

Abstract translation: 用户可以从服务器提交与提交的图像相似的一个或多个图像的图像和请求。 服务器可以基于提交的图像的内容生成图像签名。 服务器可以对图像签名进行哈希操作，以生成一个或多个哈希值。 这些哈希值可用于识别与哈希表中的图像类似的一个或多个候选图像。 这些候选图像可以基于相似性被分类并输出给用户。 可以使用汉明距离或欧氏距离中的至少一个来确定每个候选图像和图像之间的相似度。

公开(公告)号：US08577177B2

公开(公告)日：2013-11-05

申请号：US13291370

申请日：2011-11-08

Applicant: Christoph Guetter ,  Christophe Chefd'hotel ,  Hui Xue ,  Jens Guehring

Inventor： Christoph Guetter ,  Christophe Chefd'hotel ,  Hui Xue ,  Jens Guehring

IPC: G06K9/32

CPC classification number: G06T3/0068 ,  G06K2209/051

Abstract: A method for symmetric and inverse-consistent registration of a pair of digital images includes calculating a first update of a forward transformation of a first digital image to a second digital image from a previous update of the forward transformation and a gradient of a cost function of the first and second digital images, calculating a first update of a backward transformation of the second digital image to the first digital image from an inverse of the first update of the forward transformation, calculating a second update of the backward transformation from first update of the backward transformation and the gradient of a cost function of the second and first digital images, and calculating a second update of the forward transformation from an inverse of the second update of the backward transformation.

Abstract translation: 用于一对数字图像的对称和反向一致配准的方法包括从前向变换的先前更新和第一数字图像的成本函数的梯度计算第一数字图像向第二数字图像的正向变换的第一更新 所述第一数字图像和所述第二数字图像从所述正向变换的所述第一更新的逆算出计算所述第二数字图像向所述第一数字图像的反向变换的第一更新，从所述正向变换的所述第一更新计算所述反向变换的第二更新， 反向变换和第二和第一数字图像的成本函数的梯度，以及从反向变换的第二更新的倒数计算正向变换的第二更新。

公开(公告)号：US20130289912A1

公开(公告)日：2013-10-31

申请号：US13779999

申请日：2013-02-28

Applicant: Jun Liu ,  Hui Xue ,  Marcel Dominik Nickel ,  Ti-chiun Chang ,  Mariappan S. Nadar ,  Alban Lefebvre ,  Edgar Mueller ,  Qiu Wang ,  Zhili Yang ,  Nirmal Janardhanan ,  Michael Zenge

Inventor： Jun Liu ,  Hui Xue ,  Marcel Dominik Nickel ,  Ti-chiun Chang ,  Mariappan S. Nadar ,  Alban Lefebvre ,  Edgar Mueller ,  Qiu Wang ,  Zhili Yang ,  Nirmal Janardhanan ,  Michael Zenge

IPC: G01R33/24

CPC classification number: G01R33/243 ,  G01R33/246 ,  G01R33/5611

Abstract: A method for estimating a coil sensitivity map for a magnetic resonance (MR) image includes providing (61) a matrix A of sliding blocks of a 2D image of coil calibration data, calculating (62) a left singular matrix V∥ from a singular value decomposition of A corresponding to τ leading singular values, calculating (63) P=V∥V∥H, calculating (64) a matrix S that is an inverse Fourier transform of a zero-padded matrix P, and solving (65) MHcr=(Sr)Hcr for cr, where cr is a vector of coil sensitivity maps for all coils at spatial location r, and M  ( ( 1 1 … 1 0 0 … 0 … … … 0 0 … 0 )  ( 0 0 … 0 1 1 … 1 … … … 0 0 … 0 )   …   ( 0 0 … 0 0 0 … 0 … … … 1 1 … 1 ) ) .

Abstract translation: 用于估计磁共振（MR）图像的线圈灵敏度映射的方法包括提供（61）线圈校准数据的2D图像的滑块的矩阵A，从奇异值计算（62）左奇异矩阵V∥ 计算（63）P = V || V | H，计算（64）作为零填充矩阵P的逆傅里叶变换的矩阵S，求解（65）MHcr = （Sr）Hcr，其中cr是空间位置r处所有线圈的线圈灵敏度图的向量，M（（1 1 ... 1 0 0 ... 0 ... ... ... 0 0 ... 0）0（0 0 ... 0 1 1 ... 1 ... ... ... 0 0 ... 0） 0 0 0 ... 0 ... ... ... 1 1 ... 1））。

公开(公告)号：US20120121154A1

公开(公告)日：2012-05-17

申请号：US13296487

申请日：2011-11-15

Applicant: Hui Xue ,  Yixun Liu ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Jens Guhring

Inventor： Hui Xue ,  Yixun Liu ,  Christoph Guetter ,  Marie-Pierre Jolly ,  Jens Guhring

IPC: G06K9/00

CPC classification number: G06T7/33 ,  G06T2207/10088 ,  G06T2207/30048

Abstract: A method and system for propagation of myocardial infarction from delayed enhanced magnetic resonance imaging (DE-MRI) to cine MRI is disclosed. A reference frame is selected in a cine MRI sequence. Deformation fields are calculated within the cine MRI sequence to register the frames of the cine MRI sequence to the reference frame. A DE-MRI image having an infarction region is registered to the reference frame of the cine MRI sequence. The DE-MRI image may be registered to the infarction region using a hybrid registration algorithm that unifies both intensity and feature points into a single cost function. Infarction information in the DE-MRI image is then propagated cardiac phases of the frames in the cine MRI sequence based on the registration of the DE-MRI image to the reference frame and the plurality of deformation fields calculated within the cine MRI sequence.

Abstract translation: 公开了一种从延迟增强磁共振成像（DE-MRI）向电磁MRI传播心肌梗死的方法和系统。 在电影MRI序列中选择参考帧。 在电影MRI序列中计算变形场，以将电影MRI序列的帧注册到参考帧。 具有梗塞区域的DE-MRI图像被登记到电影MRI序列的参考帧。 可以使用将强度和特征点统一为单个成本函数的混合配准算法将DE-MRI图像登记到梗塞区域。 DE-MRI图像中的梗死信息然后基于DE-MRI图像的登记到参考帧和在电影MRI序列中计算的多个变形场，在电影MRI序列中的帧的心脏相位传播。

公开(公告)号：US20110239732A1

公开(公告)日：2011-10-06

申请号：US13010795

申请日：2011-01-21

Applicant: Jinchuan ZHANG ,  Ying TANG ,  Xuan TANG ,  Zhonglin SONG ,  Dejian ZHAI ,  Hui XUE

Inventor： Jinchuan ZHANG ,  Ying TANG ,  Xuan TANG ,  Zhonglin SONG ,  Dejian ZHAI ,  Hui XUE

IPC: G01N33/00

CPC classification number: G01N7/16 ,  G01N33/225

Abstract: The present invention relates to an adsorbed gas content measuring instrument and its testing method. The instrument comprises sealed cylinders, gas collecting graduated canisters and a test box, wherein the sealed cylinders are provided with valves, the gas collecting graduated canisters are equipped with drain hole adjustment valves and vent hole switching valves fit for the valve ports, and there is a heating element and a temperature controller in the test box. The method is mainly as follows: put gas-contained samples and saturated brine into the sealed cylinder, seal the cylinder, feed water in the test box and heat the box, place the sealed cylinder into the water bath of the test box, introduce saturated brine into the gas collecting graduated canister, connect the canister and cylinder, open the drain hole of the gas collecting graduated canister, record the liquid level of the graduated canister and cut off the connection after the test. The present invention has a compact structure, small volume, good gas tightness, accurate measurement, uniform heating and simple testing operation, is easy to move and carry, and suitable for field application. It can be specially used for collecting and measuring various gases, especially small-volume gas, thus it is more practical in applications.

Abstract translation: 本发明涉及吸附气体含量测量仪及其测试方法。 该仪器包括密封圆筒，气体收集分级罐和试验箱，其中密封圆柱体设有阀，气体收集分级罐配有排水孔调节阀和适合阀口的排气孔切换阀， 加热元件和温度控制器在测试箱中。 方法主要如下：将含气样品和饱和盐水放入密封圆筒中，密封圆筒，将试验箱内的水送入箱中，加热箱体，将密封圆筒放入试验箱的水浴中，引入饱和 盐水进入气体收集分级罐，连接罐和气瓶，打开集气分级罐的排水孔，记录分级罐的液位，并在试验后切断连接。 本发明结构紧凑，体积小，气密性好，测量准确，加热均匀，测试操作简单，易于移动携带，适用于现场应用。 它可以专门用于收集和测量各种气体，特别是小体积的气体，因此在应用中更为实用。

公开(公告)号：US20170015997A1

公开(公告)日：2017-01-19

申请号：US15211857

申请日：2016-07-15

Applicant: Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

Inventor： Yuzhuo Wang ,  Hui Xue ,  Sze Ue Luk ,  Peter Wilhelm Gout ,  Martin E. Gleave ,  Colin C. Collins

IPC: C12N15/113 ,  A61K9/00 ,  A61K9/127 ,  A61K31/7125

CPC classification number: C12N15/113 ,  A61K31/7125 ,  C12N2310/11 ,  C12N2310/3125 ,  C12N2310/3145 ,  C12N2310/315 ,  C12N2310/3181 ,  C12N2310/3233 ,  C12N2310/3341 ,  C12N2310/3519 ,  C12N2310/51 ,  C12N2310/321 ,  C12N2310/3525 ,  C12N2310/3527

Abstract: Provided herein are compositions, method and uses for modulating IAP activity or for the treatment of cancer. The compositions comprise dual-targeting antisense oligonucleotides (dASO) for administration to a cancer cell, wherein the cancer cell may be characterized by elevated expression of one of more of BIRC6, cIAP1 or survivin. The cancer may be selected from one or more of: prostate cancer; childhood de novo acute myeloid leukemia; colorectal cancer; neuroblastoma; melanoma; and non-small cell lung cancer. The prostate cancer may be castration-resistant prostate cancer (CRPC).

Abstract translation: 本文提供了调节IAP活性或治疗癌症的组合物，方法和用途。 所述组合物包含用于给予癌细胞的双靶向反义寡核苷酸（dASO），其中所述癌细胞的特征可能在于BIRC6，cIAP1或存活蛋白中的一种之一升高。 癌症可以选自以下中的一种或多种：前列腺癌; 儿童从头急性骨髓性白血病; 结肠直肠癌; 神经母细胞瘤 黑色素瘤 和非小细胞肺癌。 前列腺癌可能是去势抗性前列腺癌（CRPC）。

公开(公告)号：US20150342961A1

公开(公告)日：2015-12-03

申请号：US14729937

申请日：2015-06-03

Applicant: Hai-Hui Xue

Inventor： Hai-Hui Xue

IPC: A61K31/5575 ,  A61K31/506

CPC classification number: A61K31/5575 ,  A61K31/506

Abstract: Disclosed are methods and compositions for treating a patient having chronic myelogenous/myeloid leukemia (CML). The methods utilize and the compositions include prostaglandin E1 (PGE1) or Misoprotol.

Abstract translation: 公开了用于治疗患有慢性骨髓/骨髓性白血病（CML）的患者的方法和组合物。 该方法使用并且组合物包括前列腺素E1（PGE1）或米索普罗。