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公开(公告)号：US10765660B2
公开(公告)日：2020-09-08
申请号：US15634115
申请日：2017-06-27
申请人： Henry Lowe , Ngeh J. Toyang , Joseph Bryant
发明人： Henry Lowe , Ngeh J. Toyang , Joseph Bryant
IPC分类号： A61K31/353 , C07D311/32 , C07D311/60
摘要： A pharmaceutical composition for the prevention and treatment of cancer with specific flavanoid-based compounds selected from among the groups of Flavone, Flavanone and Flavanol, a method for the prevention and treatment of cancer and inflammation using the specific flavonoid-based pharmaceutical compositions, a method for isolating the flavonoid-based pharmaceutical compositions from raw plant material, and a method for synthesizing said specific flavonoid-based pharmaceutical compositions.
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公开(公告)号：US20170360744A1
公开(公告)日：2017-12-21
申请号：US15634115
申请日：2017-06-27
申请人： Henry Lowe , Ngeh J. Toyang , Joseph Bryant
发明人： Henry Lowe , Ngeh J. Toyang , Joseph Bryant
IPC分类号： A61K31/353 , C07D311/32
摘要： A pharmaceutical composition for the prevention and treatment of cancer with specific flavanoid-based compounds selected from among the groups of Flavone, Flavanone and Flavanol, a method for the prevention and treatment of cancer and inflammation using the specific flavonoid-based pharmaceutical compositions, a method for isolating the flavonoid-based pharmaceutical compositions from raw plant material, and a method for synthesizing said specific flavonoid-based pharmaceutical compositions.
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公开(公告)号：USD710795S1
公开(公告)日：2014-08-12
申请号：US29465141
申请日：2013-08-23
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公开(公告)号：US20110240214A1
公开(公告)日：2011-10-06
申请号：US12754982
申请日：2010-04-06
CPC分类号： B29C70/342
摘要： A system for processing a composite material may comprise a chamber, a mandrel, an upper ramp, and an upper diaphragm. The chamber generally provides structural support while a vacuum is applied to the system and may have a six-sided generally rectangular box shape. The mandrel generally provides support for the composite material, and may be located within the chamber. The upper ramp generally provides a path for the upper diaphragm to follow under vacuum, and may be located adjacent to the mandrel and tilted at approximately 45 degrees downward thereto. The upper diaphragm may be placed over an opening along one side of the chamber. During processing, a vacuum may be applied to chamber and the upper diaphragm may be pulled inward through the opening to press the composite material against the mandrel.
摘要翻译： 用于处理复合材料的系统可以包括腔室，心轴，上斜面和上隔膜。 腔室通常提供结构支撑，同时将真空施加到系统上，并且可具有六面体大致矩形的箱形。 心轴通常为复合材料提供支撑，并且可以位于腔室内。 上斜面通常提供用于上隔膜在真空下跟随的路径，并且可以位于与心轴相邻并且向下倾斜约45度的位置。 上隔膜可以放置在沿腔室一侧的开口上。 在处理过程中，真空可以施加到室，并且上隔膜可以通过开口向内拉，以将复合材料压靠在心轴上。
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25.发明授权公开(公告)号：US06727851B2
公开(公告)日：2004-04-27
申请号：US09957332
申请日：2001-09-20
IPC分类号： G01S302
摘要： A system for locating electromagnetic signal sources via the rotational Doppler effect whereby a radar station generating electromagnetic signals, such as radar frequency signals, initially scans the sky for aircraft. An aircraft having the system operationally installed thereon and utilizing apparatus or navigational systems already present on the aircraft receives radar signals. The system is programmed to capture radar signal parameters and extract the rotational Doppler frequencies induced by the motion of the aircraft. The angular velocity of the host platform is often the dominant source of this frequency; however, lateral velocity is not detrimental to the process. The measurement of the rotational Doppler frequency is accomplished through antennas presently installed on large numbers of military aircraft with no requirement for phase calibration of the electrical paths between antennas and receiver. The method requires synchronization of these measurements with data from the navigation system (INS, EGI, or other) that describes the aircraft motion during the measurement process. The method applies an equation combining several navigation parameters to predict the theoretical rotational Doppler frequencies from hypothetical emitter locations. Prediction of the unknown emitter location from a sequence of measured rotational Doppler frequencies is accomplished by the principle of least squares estimation based on the previously referenced equation.
摘要翻译： 一种用于通过旋转多普勒效应来定位电磁信号源的系统，由此产生诸如雷达频率信号的电磁信号的雷达站最初扫描飞机的天空。 具有操作地安装在其上并利用已经存在于飞行器上的装置或导航系统的飞机接收雷达信号。 该系统被编程以捕获雷达信号参数并提取由飞行器的运动引起的旋转多普勒频率。 主机平台的角速度通常是该频率的主要来源; 然而，侧向速度对该过程是不利的。 旋转多普勒频率的测量通过目前安装在大量军用飞机上的天线来实现，不需要天线和接收机之间的电路径的相位校准。 该方法需要这些测量与来自导航系统（INS，EGI或其他）的数据同步，该导航系统描述了在测量过程中的飞行器运动。 该方法应用组合几个导航参数的方程式来从假设的发射器位置预测理论旋转多普勒频率。 根据测量的旋转多普勒频率序列对未知发射器位置的预测通过基于先前参考方程的最小二乘估计原理来实现。
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26.发明授权Treatment and prevention of HIV infection by administration of derivatives of human chorionic gonadotropin 有权通过施用人绒毛膜促性腺激素衍生物治疗和预防HIV感染公开(公告)号：US06699656B2
公开(公告)日：2004-03-02
申请号：US10050875
申请日：2001-11-20
IPC分类号： C12Q170
CPC分类号： C07K14/59 , A61K38/00 , Y10S435/974
摘要： The present invention relates to &bgr;-hCG, particularly &bgr;-hCG proteins having a sequence of amino acids 41-54, 45-54, 47-53, 45-57 and 45-58 and analogs and derivatives thereof. The invention further relates to methods of treatment and prevention of HIV infection by administration of a therapeutic compound of the invention. Such therapeutic compounds include hCG, &bgr;-hCG and &bgr;-hCG peptides, analogs and derivatives of hCG, &bgr;-hCG and &bgr;-hCG peptides, and nucleic acids encoding hCG, &bgr;-hCG and &bgr;-hCG peptides. In a preferred embodiment, &bgr;-hCG peptides, particularly &bgr;-hCG peptides of amino acids 47-53, 45-57 or 45-58 are administered to a subject for treatment or prevention of HIV infection in that subject. The invention also provides methods for screening hCG preparations for activity in treating or preventing HIV infection. Pharmaceutical compositions and methods of administration of Therapeutics are also provided.
摘要翻译： 本发明涉及β-hCG，特别是具有41-54,45-54,47-53,45-57和45-58位氨基酸序列的β-hCG蛋白及其类似物和衍生物。 本发明还涉及通过施用本发明的治疗化合物治疗和预防HIV感染的方法。 这些治疗化合物包括hCG，β-hCG和β-hCG肽，hCG，β-hCG和β-hCG肽的类似物和衍生物，以及编码hCG，β-hCG和β-hCG肽的核酸。 在优选的实施方案中，将Aβ-hCG肽，特别是氨基酸47-53,45-57或45-58的β-hCG肽施用于受试者，以治疗或预防该受试者的HIV感染。 本发明还提供了用于筛选用于治疗或预防HIV感染的活性的hCG制剂的方法。 还提供药物组合物和治疗剂的施用方法。
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公开(公告)号：USD823239S1
公开(公告)日：2018-07-17
申请号：US29576717
申请日：2016-09-06
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28.发明申请AGENT CONTAINING FLAVONOID DERIVATIVES FOR TREATING CANCER AND INFLAMMATION 有权含有FLAVONOID衍生物用于治疗癌症和炎症的药剂公开(公告)号：US20160145230A1
公开(公告)日：2016-05-26
申请号：US14835198
申请日：2015-08-25
申请人： Henry Lowe , Ngeh J. Toyang , Joseph Bryant
发明人： Henry Lowe , Ngeh J. Toyang , Joseph Bryant
IPC分类号： C07D311/32
CPC分类号： A61K31/353 , C07D311/32 , C07D311/60
摘要： A pharmaceutical composition for the prevention and treatment of cancer with specific flavanoid-based compounds selected from among the groups of Flavone, Flavanone and Flavanol, a method for the prevention and treatment of cancer and inflammation using the specific flavonoid-based pharmaceutical compositions, a method for isolating the flavonoid-based pharmaceutical compositions from raw plant material, and a method for synthesizing said specific flavonoid-based pharmaceutical compositions.
摘要翻译： 一种用于预防和治疗癌症的药物组合物，其特征在于选自黄酮，黄酮和黄烷醇的类黄酮类化合物，使用特定类黄酮类药物组合物预防和治疗癌症和炎症的方法 用于从原料植物材料中分离基于类黄酮的药物组合物和用于合成所述特定类黄酮的药物组合物的方法。
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29.发明申请BIOLOGICALLY ACTIVE POLYPEPTIDES DERIVED FROM A NOVEL EARLY STAGE PREGNANCY FACTOR DESIGNATED MATERNIN (MA) 审中-公开从一个新的早期阶段产生的生物活性多肽被指定的MATERNIN（MA）公开(公告)号：US20120083587A1
公开(公告)日：2012-04-05
申请号：US13159285
申请日：2011-06-13
CPC分类号： C07K16/26 , A61K38/00 , A61K48/00 , C07K14/59 , C07K2319/00
摘要： The invention relates to therapeutic polypeptides isolated from beta-human chorionic gonadotropin (β-hCG) found in human early pregnancy urine, now synthetically produced and designated Maternin. The therapeutic polypeptides and their functional equivalents are useful in treating and/or preventing various medical conditions. Examples of therapeutic effects of the therapeutic polypeptides include anti-HIV, anti-cancer, anti-wasting, prohematopoietic (e.g., anemias, radiation-mediated bone marrow damage, and trauma-mediated blood loss), and anti-angiogenic effects. The invention also provides pharmaceutical compositions comprising the therapeutic polypeptides, as well as methods for using the therapeutic polypeptides, functional equivalents and/or pharmaceutical compositions in the treatment and/or prevention of such medical conditions.
摘要翻译： 本发明涉及从人类早孕尿中发现的β-人绒毛膜促性腺激素（＆bgr--hCG）分离的治疗性多肽，现在合成产生并命名为Maternin。 治疗性多肽及其功能等同物可用于治疗和/或预防各种医疗状况。 治疗性多肽的治疗效果的实例包括抗HIV，抗癌，抗浪费，造血（例如，贫血，辐射介导的骨髓损伤和创伤介导的失血）和抗血管生成作用。 本发明还提供了包含治疗性多肽的药物组合物，以及使用治疗性多肽，功能等同物和/或药物组合物治疗和/或预防这些医学病症的方法。
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公开(公告)号：US06596688B1
公开(公告)日：2003-07-22
申请号：US09675776
申请日：2000-09-29
IPC分类号： A01N3718
CPC分类号： C07K14/59
摘要： The present invention relates to peptides of one or more portions of the human chorionic gonadotropin &bgr;-chain as well as methods of promoting hematopoiesis, using human chorionic gonadotropin, employing the &bgr;-chain of human chorionic gonadotropin, peptides containing a sequence of one or more portions of the &bgr;-chain of human chorionic gonadotropin and derivatives and analogues thereof. The invention further relates to fractions of sources and or perparations of human chorionic gonadotropin, such as fractions of humna early pregnancy urine, which fractions have pro-hematopoietic activity. The present invention further relates to pharmaceutical compositions for promoting hematopoiesis.
摘要翻译： 本发明涉及人绒毛膜促性腺激素β链的一个或多个部分的肽以及使用人绒毛膜促性腺激素促进造血的方法，其使用人绒毛膜促性腺激素的β链，含有一个或多个 人绒毛膜促性腺激素的β-链的部分及其衍生物和类似物。 本发明进一步涉及人绒毛膜促性腺激素的来源和/或起始部分，例如妊娠期尿液的部分，这些部分具有促造血活性。 本发明还涉及用于促进造血作用的药物组合物。
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