公开(公告)号：US20240294673A1

公开(公告)日：2024-09-05

申请号：US18564921

申请日：2022-05-27

申请人： JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG

发明人： Gernot STUHLER ,  Tim SCHNYDER ,  Boris NOWOTNY ,  Annika BREMER

IPC分类号： C07K16/46 ,  A61K39/00 ,  C07K16/28 ,  C07K16/30 ,  C07K16/32

CPC分类号： C07K16/468 ,  C07K16/2863 ,  C07K16/30 ,  C07K16/32 ,  A61K2039/505 ,  C07K2317/31 ,  C07K2317/526 ,  C07K2317/64 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/94

摘要： The present invention relates to a recombinant proteinaceous binding molecule wherein an Fc fragment is used as fusion partner and combined it with the hemibody technology. Furthermore, the invention relates to a heterodimeric recombinant proteinaceous binding molecule, as well as a method for producing the same, its use and a nucleic acid molecule encoding the recombinant proteinaceous binding molecule. The invention in particular provides a proteinaceous binding molecule that is capable of mediating target cell restricted activation of immune cells.

公开(公告)号：US11891352B2

公开(公告)日：2024-02-06

申请号：US16975077

申请日：2019-02-20

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Lorenz Meinel ,  Tessa Luehmann ,  Martina Raschig

IPC分类号： C07C237/04 ,  C07C231/12 ,  C07K1/10

CPC分类号： C07C237/04 ,  C07C231/12 ,  C07K1/10

摘要： The present invention is directed to compounds of the general formula (I) and salts thereof




wherein X− is halide, pseudohalide, sulphate, benzoate, acetate, trifluoroacetate, hydroxide, saccharinate or capsaicinate; R10 is hydrogen or C1-C10-alkyl; and R1-R9 independently are hydrogen, halogen, C1-C5-alkyl, C1-C4-alkoxy, C1-C20-alkoxycarbonyl. The invention is furthermore directed to a method for the preparation of these compounds. The compounds can be used as bitter substances in medicine, pharmaceutics and/or diagnostics. They can furthermore be used for the coupling to proteins and peptides by means of forming a peptide bond between the amino-group of the compounds of the present invention and a carboxyl-group of the protein or peptide.

公开(公告)号：US20240002898A1

公开(公告)日：2024-01-04

申请号：US18038393

申请日：2021-11-24

申请人： Helmholtz Zentrum Muenchen - Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (GmbH) ,  Julius-Maximilians-Universitaet Wuerzburg

发明人： Ali DORYAB ,  Otmar SCHMID ,  Andreas SCHROEPPEL ,  Juergen GROLL ,  Mehmet Berat TASKIN

IPC分类号： C12Q1/02 ,  C12M1/12 ,  C12M1/34 ,  C12M1/00

CPC分类号： C12Q1/02 ,  C12M25/04 ,  C12M41/40 ,  C12M29/10 ,  C12M41/46

摘要： In various embodiments a biocompatible composite membrane for in vitro cell culturing comprising a first material, which is non-water soluble and a water soluble second material is provided, wherein the composite membrane comprises a porous scaffold and a filling layer, the scaffold comprising the first material and the filling layer comprising the second material. Further, a method for fabricating the membrane, a bioreactor for use of the membrane in cell-stretch experiments and a corresponding method for investigating cells attached to the biocompatible composite membrane are also provided.

公开(公告)号：US20230112937A1

公开(公告)日：2023-04-13

申请号：US17911327

申请日：2021-03-12

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Lorenz MEINEL ,  Matthias RUOPP ,  Wolfgang SCHMEHL ,  Marcus Otto GUTMANN

IPC分类号： A61K9/70 ,  A61K33/26 ,  A61K9/00

摘要： The present invention discloses a therapeutic system for the topic, transdermal and transcutaneous application of carbon monoxide (CO), comprising: (i) an adhesive layer, (ii) a gas-permeable and liquid- and solid-impermeable membrane, (iii) a reaction chamber comprising a CO releasing molecule A, and (iv) a gas-impermeable backing layer, wherein the transdermal therapeutic system is configured that the CO releasing molecule A can be brought into contact with a CO release triggering compound B in the reaction chamber (iii). The therapeutic system can be used for the treatment of wounds, inflammatory diseases of the skin, and inflammatory diseases of subcutaneous skin tissue, joints and tendons.

公开(公告)号：US20230091608A1

公开(公告)日：2023-03-23

申请号：US17440319

申请日：2020-03-13

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Lorenz MEINEL ,  Jennifer RITZER ,  Tobias MIESLER

IPC分类号： C07C237/04 ,  A61K49/00 ,  C07K7/06

摘要： The present invention relates to compounds comprising denatonium linked to the C-terminus of a protease-sensitive peptide; or a salt thereof. The compounds are useful in the diagnosis of inflammatory conditions of the oral cavity.

公开(公告)号：US11377463B2

公开(公告)日：2022-07-05

申请号：US16645380

申请日：2018-08-29

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Christian Possiel ,  Juergen Seibel

IPC分类号： C07H7/033 ,  C12P19/12 ,  C12P19/18

摘要： A new class of sucrose esters and a method for their preparation is described herein.

公开(公告)号：US20210317267A1

公开(公告)日：2021-10-14

申请号：US17348157

申请日：2021-06-15

申请人： JULIUS-MAXIMILIANS-UNIVERSITAET WUERZBURG

发明人： THOMAS LORSON ,  ROBERT LUXENHOFER

IPC分类号： C08G73/02 ,  C08J3/075 ,  B33Y70/00 ,  A61K47/59 ,  A61L27/18 ,  A61L27/38 ,  A61L27/44

摘要： Block copolymers have a general chemical structure of one of the formulas [A]n-[B]m and [B]n-[A]m, wherein block [A] is a poly(2-oxazine) and wherein block [B] is a poly(2-oxazoline). The block copolymers have desired thermogelling and rheological properties and are useful as carrier materials for active ingredients such as drugs, cells, proteins, and other active ingredients.

公开(公告)号：US20200155727A1

公开(公告)日：2020-05-21

申请号：US16748054

申请日：2020-01-21

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Kai Stuckensen ,  Uwe Gbureck ,  Juergen Groll

IPC分类号： A61L27/56 ,  A61L27/24 ,  A61L27/20 ,  A61L27/12 ,  A61F2/30

摘要： The present invention relates to a monolithic multi-layered material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a monolithic medical material having at least a first layer, from which anisotropic pores originate, and a second layer, in which the anisotropic pores continue. The present invention further relates to a process for the production of a multi-layered material having anisotropic pores. It further relates to a multi-layered material which can be produced by the process according to the invention.

公开(公告)号：US20190209710A1

公开(公告)日：2019-07-11

申请号：US16334293

申请日：2017-08-28

申请人： Julius-Maximilians-Universitaet Wuerzburg

发明人： Lorenz MEINEL ,  Tobias MIESLER ,  Juergen SEIBEL

IPC分类号： A61K49/00 ,  C07H5/06

CPC分类号： A61K49/0004 ,  C07H5/06 ,  C12Q1/04 ,  C12Q1/34

摘要： The subject matter of the invention is a diagnostic sensor that can be formulated into a diagnostic chewing gum that detects relevant concentrations of influenza viruses in the oral cavity. The technical application is the initial diagnosis by those affected themselves, e.g. sore throats manifesting in them. By the detection of the influenza viruses a selective therapy of the infection is possible and employment of antibiotics that only are effective with bacterial diseases can be reduced.

公开(公告)号：US20190170667A1

公开(公告)日：2019-06-06

申请号：US16252130

申请日：2019-01-18

申请人： Fraunhofer-Gesellschaft zur Foerderung der angewandten Forschung e.V. ,  Julius-Maximilians-Universitaet Wuerzburg

发明人： Richard SCHIELEIN ,  Wolfgang HOLUB

IPC分类号： G01N23/046 ,  G01N23/18

摘要： A calculating unit for calculating a recording trajectory of a CT system has a receive interface, an optimizer and a control unit. The receive interface serves for receiving measurement and simulation data relative to the object to be recorded. The optimizer is configured to determine the recording trajectory based on known degrees of freedom of the CT system, based on the measurement and simulation data and based on a test task from a group having a plurality of test tasks. The control unit is configured to output data in correspondence with the recording trajectory for controlling the CT system.