公开(公告)号：US20060143774A1

公开(公告)日：2006-07-06

申请号：US11001545

申请日：2004-12-01

申请人： Kenneth Walsh ,  Richard Siberell

发明人： Kenneth Walsh ,  Richard Siberell

IPC分类号： A41D3/02 ,  A41D1/00

CPC分类号： A41D13/0012

摘要： An article of clothing with three-dimensional, molded pockets. Preferably, the molded pockets are constructed of a fabric/foam laminate that has been heat/compression molded. In a preferred embodiment, the molded pockets find utility in the containment of fly boxes and other accessories used in fly fishing. A method of manufacturing a garment with three-dimensional, molded pockets.

摘要翻译： 一件三维造型口袋的服装。 优选地，模制袋由已经被热/压缩模制的织物/泡沫层压体构成。 在优选实施例中，模制袋可用于飞蝇捕获中使用的飞行物箱和其它附件的容纳物。 制造具有三维模制口袋的衣服的方法。

公开(公告)号：US5990092A

公开(公告)日：1999-11-23

申请号：US927394

申请日：1997-08-27

申请人： Kenneth Walsh

发明人： Kenneth Walsh

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K48/00 ,  A61P9/14 ,  C07K14/47 ,  C12N15/12 ,  C12N15/85

CPC分类号： C07K14/4702 ,  A61K38/1709 ,  A61K48/00

摘要： Methods and compositions for reducing or preventing the proliferation of vascular smooth muscle cells are provided. The method involves the step of administering an isolated GATA-6 molecule to a subject to prevent or reduce vascular smooth muscle cell proliferation. The isolated GATA-6 molecule can be a GATA-6 nucleic acid or a GATA-6 protein.

摘要翻译： 提供了减少或预防血管平滑肌细胞增殖的方法和组合物。 该方法包括向受试者施用分离的GATA-6分子以防止或减少血管平滑肌细胞增殖的步骤。 分离的GATA-6分子可以是GATA-6核酸或GATA-6蛋白。

公开(公告)号：US20190292256A1

公开(公告)日：2019-09-26

申请号：US16259150

申请日：2019-01-28

申请人： Kenneth Walsh ,  Noriyuki Ouchi

发明人： Kenneth Walsh ,  Noriyuki Ouchi

IPC分类号： C07K16/28 ,  C07K16/18 ,  A61K38/17

摘要： The invention relates to treatment to restore normal metabolic function, including but not limited to normal glucose levels. The invention in one embodiment contemplates methods of reducing elevated glucose levels in subjects with elevated glucose levels by administering a composition comprising at least a portion of human Sfrp5. The invention in one embodiment contemplates methods of reducing elevated glucose levels in subjects with elevated glucose levels by administering a composition comprising an inhibitor of Wnt5a, including but not limited to an antibody inhibitor.

公开(公告)号：US20110191871A1

公开(公告)日：2011-08-04

申请号：US12281115

申请日：2007-02-23

申请人： Kenneth Walsh ,  Noriyuki Ouchi ,  Yasuhiro Izumiya

发明人： Kenneth Walsh ,  Noriyuki Ouchi ,  Yasuhiro Izumiya

IPC分类号： C12Q1/68 ,  C12N5/10 ,  A01K67/00

CPC分类号： A61K38/2221 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/39 ,  A61K38/45 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The present invention relates to methods to identify factors associated with muscle growth, angiogenesis, obesity, insulin sensitivity body weight, fat mass, muscle mass and cardiovascular function. In particular, the methods of the present invention relates to assays to identify such factors using a transgenic animal model and/or a cell-based assay.

摘要翻译： 本发明涉及鉴别与肌肉生长，血管生成，肥胖，胰岛素敏感性体重，脂肪量，肌肉质量和心血管功能相关的因素的方法。 特别地，本发明的方法涉及使用转基因动物模型和/或基于细胞的测定来鉴定这些因子的测定。

公开(公告)号：US20090142336A1

公开(公告)日：2009-06-04

申请号：US12280961

申请日：2007-02-23

申请人： Kenneth Walsh ,  Noriyuki Ouchi ,  Ling Zeng

发明人： Kenneth Walsh ,  Noriyuki Ouchi ,  Ling Zeng

IPC分类号： A61K39/395 ,  A61K31/7088 ,  A61K31/7105 ,  A61K38/02

CPC分类号： A61K38/2221 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/39 ,  A61K38/45 ,  C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： The present invention relates to metabolic regulators that affect metabolic function, for example metabolic regulators that affect muscle mass, muscle regeneration, muscle hypertrophy, fat mass, insulin and glucose sensitivity, angiogenesis and cardiovascular function. In particular, the present invention relates to modulating metabolic function by administering an effective amount of a pharmaceutical composition comprising an agent, where the agent activates or inhibits the activity and/or gene expression of the metabolic regulator. The metabolic regulators of the present invention are, for example MSP1 (2160028F08Rik; SEQ ID NO: 16); MSP2 (2310043I08Rik; SEQ ID NO: 17); MSP3 (NM_026754;1 110017116Rik; SEQ ID NO: 1); MSP4 (4732466D17Rik; SEQ BD NO: 18); MSP 5 (NM_024237; 1600015H20Rik; SEQ ID NO: 12); Ins16 (AF_156094; SEQ ID NO: 20). The present invention also provides methods to screen for agents that affect the metabolic regulators of the present invention.

摘要翻译： 本发明涉及影响代谢功能的代谢调节剂，例如影响肌肉质量的代谢调节剂，肌肉再生，肌肉肥大，脂肪量，胰岛素和葡萄糖敏感性，血管生成和心血管功能。 特别地，本发明涉及通过施用有效量的包含试剂的药物组合物调节代谢功能，其中所述试剂活化或抑制代谢调节剂的活性和/或基因表达。 本发明的代谢调节剂是例如MSP1（2160028F08Rik; SEQ ID NO：16）; MSP2（2310043I08Rik; SEQ ID NO：17）; MSP3（NM_026754; 110017116Rik; SEQ ID NO：1）; MSP4（4732466D17Rik; SEQ ID NO：18）; MSP 5（NM_024237; 1600015H20Rik; SEQ ID NO：12）; Ins16（AF_156094; SEQ ID NO：20）。 本发明还提供筛选影响本发明的代谢调节剂的试剂的方法。

公开(公告)号：US20060048263A1

公开(公告)日：2006-03-09

申请号：US10936334

申请日：2004-09-08

申请人： Kenneth Walsh

发明人： Kenneth Walsh

IPC分类号： A41D13/00

CPC分类号： A41D27/10 ,  A41D2400/34 ,  A41D2400/60

摘要： A garment comprising different portions having different performance characteristics. A preferred embodiment is a fishing shirt comprising: a body portion, said body portion being fabricated from a breathable, knitted fabric having a wicking finish; a collar portion and a yoke portion, said collar portion and said yoke portion being fabricated from a four-way stretch fabric having a wicking finish; a pair of lower sleeve portions, each of said lower sleeve portions being fabricated from a non-wicking, hydrophobic fabric; and a pair of underarm portions, each of said underarm portions being fabricated from a knit, anti-microbial fabric.

摘要翻译： 一种衣服，其包括具有不同性能特征的不同部分。 优选实施例是一种钓鱼衬衫，包括：主体部分，所述主体部分由具有芯吸整理剂的透气针织物制成; 轴环部分和轭部分，所述轴环部分和所述轭部由具有芯吸整理剂的四向弹性织物制成; 一对下套筒部分，每个所述下套筒部分由非吸湿疏水织物制成; 和一对腋下部分，每个所述腋下部分由编织的抗菌织物制成。

公开(公告)号：US06689807B1

公开(公告)日：2004-02-10

申请号：US09590740

申请日：2000-06-08

申请人： Kenneth Walsh

发明人： Kenneth Walsh

IPC分类号： A01N4336

CPC分类号： A61K31/4418 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/404 ,  A61K38/553 ,  A61K45/06

摘要： This invention relates to methods and compositions for the treatment of conditions associated with vascular insufficiency, and to methods and compositions for screening assays to select agents that are useful for this purpose. In particular the invention relates to HMG CoA reductase inhibitors and their use in promoting angiogenesis in vivo and in activating Akt in vascular endothelial cells in vitro and in vivo.

公开(公告)号：US06369039B1

公开(公告)日：2002-04-09

申请号：US09204254

申请日：1998-12-03

申请人： Maria Palasis ,  Kenneth Walsh

发明人： Maria Palasis ,  Kenneth Walsh

IPC分类号： A61K4800

CPC分类号： A61M25/104 ,  A61M2025/105

摘要： A method of site-specifically delivering a therapeutic agent to a target location within a body cavity, vasculature or tissue. The method comprises the steps of providing a medical device having a substantially saturated solution of therapeutic agent associated therewith; introducing the medical device into the body cavity, vasculature or tissue; releasing a volume of the solution of therapeutic agent from the medical device at the target location at a pressure of from about 0 to about 5 atmospheres for a time of up to about 5 minutes; and withdrawing the medical device from the body cavity, vasculature or tissue. In another aspect, the present invention includes a system for delivering a therapeutic agent to a body cavity, vasculature or tissue, comprising a medical device having a substantially saturated solution of the therapeutic agent associated therewith.

摘要翻译： 将治疗剂特异性递送到体腔，脉管系统或组织内的目标位置的方法。 该方法包括提供具有基本上饱和的与其相关的治疗剂溶液的医疗装置的步骤; 将医疗器械引入体腔，血管或组织; 在约0至约5个大气压的压力下，在目标位置从医疗装置释放一定体积的治疗剂，持续约5分钟; 并从体腔，血管或组织中取出医疗装置。 另一方面，本发明包括用于将治疗剂递送至体腔，脉管系统或组织的系统，其包括具有与其相关联的治疗剂的基本饱和溶液的医疗装置。

公开(公告)号：US06280969B1

公开(公告)日：2001-08-28

申请号：US09078465

申请日：1998-05-14

申请人： David H. Gorski ,  Kenneth Walsh

发明人： David H. Gorski ,  Kenneth Walsh

IPC分类号： C12N1512

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

摘要翻译： 已经发现了一种新的生长停滞同源盒基因，并且已经在大鼠和人中确定了核苷酸序列。 新型同源盒基因的表达抑制血管平滑肌细胞生长。 生长停滞同源盒基因以下简称为“Gax基因”及其相应的蛋白质可用于血管平滑肌细胞增殖的研究，以及由过度平滑肌细胞增殖引起的血管疾病的治疗，特别是球囊血管成形术 。

公开(公告)号：US20110274689A1

公开(公告)日：2011-11-10

申请号：US13100895

申请日：2011-05-04

申请人： Kenneth Walsh ,  Noriyuki Ouchi

发明人： Kenneth Walsh ,  Noriyuki Ouchi

IPC分类号： A61K38/16 ,  G01N33/53 ,  C12Q1/68 ,  G01N33/566 ,  A61K39/395 ,  A61P3/08

摘要： The invention relates to treatment to restore normal metabolic function, including but not limited to normal glucose levels. The invention in one embodiment contemplates methods of reducing elevated glucose levels in subjects with elevated glucose levels by administering a composition comprising at least a portion of human Sfrp5. The invention in one embodiment contemplates methods of reducing elevated glucose levels in subjects with elevated glucose levels by administering a composition comprising an inhibitor of Wnt5a, including but not limited to an antibody inhibitor.

摘要翻译： 本发明涉及恢复正常代谢功能的治疗，包括但不限于正常的葡萄糖水平。 在一个实施方案中，本发明考虑了通过施用包含至少一部分人Sfrp5的组合来降低具有升高的葡萄糖水平的受试者的升高的葡萄糖水平的方法。 在一个实施方案中，本发明考虑了通过施用包含但不限于抗体抑制剂的Wnt5a抑制剂的组合物降低葡萄糖水平升高的受试者中升高的葡萄糖水平的方法。