公开(公告)号：USRE39219E1

公开(公告)日：2006-08-01

申请号：US09755320

申请日：2001-01-05

申请人： David H. Gorski ,  Kenneth Walsh

发明人： David H. Gorski ,  Kenneth Walsh

IPC分类号： C12N15/12 ,  C12N15/63 ,  C12N1/21 ,  C12N5/10

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

摘要翻译： 已经发现了一种新的生长停滞同源盒基因，并且已经在大鼠和人中确定了核苷酸序列。 新型同源盒基因的表达抑制血管平滑肌细胞生长。 生长停滞同源盒基因以下简称为“Gax基因”及其相应的蛋白质可用于血管平滑肌细胞增殖的研究，以及由过度平滑肌细胞增殖引起的血管疾病的治疗，特别是球囊血管成形术 。

公开(公告)号：US06897293B2

公开(公告)日：2005-05-24

申请号：US09940673

申请日：2001-08-27

申请人： David H. Gorski ,  Kenneth Walsh

发明人： David H. Gorski ,  Kenneth Walsh

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K48/00 ,  A61P7/02 ,  A61P9/10 ,  A61P43/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C12N1/21 ,  C12N15/12 ,  C07K1/00 ,  C12P21/06

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

摘要翻译： 已经发现了一种新的生长停滞同源盒基因，并且已经在大鼠和人中确定了核苷酸序列。 新型同源盒基因的表达抑制血管平滑肌细胞生长。 生长停滞同源盒基因以下简称为“Gax基因”及其相应的蛋白质可用于血管平滑肌细胞增殖的研究，以及由过度平滑肌细胞增殖引起的血管疾病的治疗，特别是球囊血管成形术 。

公开(公告)号：US06280969B1

公开(公告)日：2001-08-28

申请号：US09078465

申请日：1998-05-14

申请人： David H. Gorski ,  Kenneth Walsh

发明人： David H. Gorski ,  Kenneth Walsh

IPC分类号： C12N1512

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the “Gax gene” and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.

摘要翻译： 已经发现了一种新的生长停滞同源盒基因，并且已经在大鼠和人中确定了核苷酸序列。 新型同源盒基因的表达抑制血管平滑肌细胞生长。 生长停滞同源盒基因以下简称为“Gax基因”及其相应的蛋白质可用于血管平滑肌细胞增殖的研究，以及由过度平滑肌细胞增殖引起的血管疾病的治疗，特别是球囊血管成形术 。

公开(公告)号：US5856121A

公开(公告)日：1999-01-05

申请号：US203532

申请日：1994-02-24

申请人： David H. Gorski ,  Kenneth Walsh

发明人： David H. Gorski ,  Kenneth Walsh

IPC分类号： C12N15/09 ,  A61K31/70 ,  A61K38/00 ,  A61K48/00 ,  A61P7/02 ,  A61P9/10 ,  A61P43/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/52 ,  C12N1/21 ,  C12N15/12 ,  C12N5/10 ,  C12N15/63

CPC分类号： C07K14/4703 ,  A61K38/00

摘要： A novel growth arrest homeobox gene has been discovered and the nucleotide sequences have been determined in both the rat and the human. The expression of the novel homeobox gene inhibits vascular smooth muscle cell growth. The growth arrest homeobox gene hereinafter referred to as the "Gax gene" and its corresponding proteins are useful in the study of vascular smooth muscle cell proliferation and in the treatment of blood vessel diseases that result from excessive smooth muscle cell proliferation, particularly after balloon angioplasty.