公开(公告)号：USD727167S1

公开(公告)日：2015-04-21

申请号：US29434923

申请日：2012-10-18

Applicant: LEO Pharma A/S

Designer： Alun Wilcox ,  Peter Sprada ,  Graeme Howard Davies ,  Nicholas Henry Reddall ,  Joshua Thomas Richards

公开(公告)号：USD718130S1

公开(公告)日：2014-11-25

申请号：US29434947

申请日：2012-10-18

Applicant: LEO Pharma A/S

Designer： Alun Wilcox ,  Peter Sprada ,  Graeme Howard Davies ,  Nicholas Henry Reddall ,  Joshua Thomas Richards

公开(公告)号：US12065429B2

公开(公告)日：2024-08-20

申请号：US18526149

申请日：2023-12-01

Applicant: LEO Pharma A/S

Inventor： Mark Andrews ,  Mogens Larsen ,  Alan Jessiman ,  Patrick Johnson ,  Kevin Neil Dack

IPC: C07D401/14

CPC classification number: C07D401/14

Abstract: The present invention relates to a compound according to formula (I)




and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to said compounds for use in therapy, to pharmaceutical compositions comprising said compounds, to methods of treating diseases, e.g., dermal diseases, with said compounds, and to the use of said compounds in the manufacture of medicaments.

公开(公告)号：US20230398131A1

公开(公告)日：2023-12-14

申请号：US18154695

申请日：2023-01-13

Applicant: LEO Pharma A/S

Inventor： Marianne LIND ,  Gritt RASMUSSEN ,  Mette Rydahl SONNE ,  Jens HANSEN ,  Karsten PETERSSON

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22

CPC classification number: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/0014 ,  A61K9/122 ,  A61K31/573 ,  A61K31/58 ,  A61K9/124 ,  A61M35/003 ,  A61K47/14 ,  A61K47/22 ,  A61M2210/04 ,  B65D83/207

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US20200323869A1

公开(公告)日：2020-10-15

申请号：US16468444

申请日：2017-12-12

Applicant: LEO PHARMA A/S

Inventor： Xifu LIANG ,  Jens LARSEN ,  Simon Feldbaek NIELSEN ,  Peter ANDERSEN

IPC: A61K31/55 ,  C07D491/20

Abstract: The present invention relates to novel substituted pyrazoloazepin-4-ones with phosphodiesterase inhibitory activity, as well as to their use as therapeutic agents in the treatment of inflammatory diseases and conditions.

公开(公告)号：US20190381074A1

公开(公告)日：2019-12-19

申请号：US16554586

申请日：2019-08-28

Applicant: LEO Pharma A/S

Inventor： Marianne LIND ,  Gritt RASMUSSEN ,  Mette Rydahl SONNE ,  Jens HANSEN ,  Karsten PETERSSON

IPC: A61K31/593 ,  A61K47/22 ,  A61K47/14 ,  A61M35/00 ,  A61K9/12 ,  A61K31/58 ,  A61K31/573 ,  A61K9/00 ,  A61M11/00 ,  A61K47/08 ,  A61K47/06 ,  A61K31/59

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US20190381073A1

公开(公告)日：2019-12-19

申请号：US16554501

申请日：2019-08-28

Applicant: LEO Pharma A/S

Inventor： Marianne LIND ,  Gritt RASMUSSEN ,  Mette Rydahl SONNE ,  Jens HANSEN ,  Karsten PETERSSON

IPC: A61K31/593 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/573 ,  A61K31/58 ,  A61M35/00 ,  A61K47/14 ,  A61K47/22

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analogue and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

公开(公告)号：US20180263986A1

公开(公告)日：2018-09-20

申请号：US15762188

申请日：2016-09-22

Applicant: LEO Pharma A/S ,  Japan Tobacco Inc.

Inventor： Michael SIERRA ,  Tord LABUDA ,  Atsuo TANIMOTO ,  Yuichi SHINOZAKI

IPC: A61K31/519 ,  A61P17/14 ,  A61K9/00

CPC classification number: A61K31/519 ,  A61K9/0014 ,  A61K9/06 ,  A61K47/06 ,  A61P17/14

Abstract: The present invention provides a novel treatment of alopecia areate. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent for alopecia areata, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient.

公开(公告)号：US09637499B2

公开(公告)日：2017-05-02

申请号：US14872487

申请日：2015-10-01

Applicant: LEO PHARMA A/S

Inventor： Simon Feldbaek Nielsen

IPC: A01N43/42 ,  A61K31/44 ,  C07D495/10 ,  C07D493/10 ,  A61K31/4427 ,  A61K31/4433 ,  A61K9/00 ,  A61K31/443 ,  A61K31/4436

CPC classification number: C07D495/10 ,  A61K9/0053 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/4436 ,  C07D493/10

Abstract: Compounds of the general formula I wherein each of m and n is independently 0 or 1; R1 and R2, together with the carbon atom to which they are attached, form a heterocyclic ring comprising one or two heteroatoms selected from oxygen, sulfur, —S(O)— and —S(O)2—; R3 is —CHF2, —CF3, —OCHF2, —OCF3, —SCHF2 or —SCF3; X is a bond, —CH2—, or —NH—; A is aryl, cycloalkyl, cycloalkenyl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycloalkyl or heterocycloalkenyl, optionally substituted with one or more, same or different substituents selected from R4; and R4 is hydrogen, amino, thioxo, alkyl, haloalkyl, hydroxyalkyl, alkoxy, haloalkoxy, halogen, oxo, thia, or hydroxy; or pharmaceutically acceptable salts, hydrates or solvates thereof, have been found to exhibit PDE4 inhibiting activity, and may therefore be useful in the treatment of inflammatory diseases and disorders.

公开(公告)号：US09566286B2

公开(公告)日：2017-02-14

申请号：US14707662

申请日：2015-05-08

Applicant: LEO PHARMA A/S

Inventor： Marianne Lind ,  Gritt Rasmussen ,  Mette Rydahl Sonne ,  Jens Hansen ,  Karsten Petersson

IPC: A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61M11/00 ,  A61K9/00 ,  A61K9/12 ,  A61K31/57 ,  A61K31/58 ,  A61M35/00 ,  A61K31/573 ,  A61K31/593

CPC classification number: A61K31/593 ,  A61K9/0014 ,  A61K9/122 ,  A61K9/124 ,  A61K31/573 ,  A61K31/58 ,  A61K31/59 ,  A61K47/06 ,  A61K47/08 ,  A61K47/14 ,  A61K47/22 ,  A61M11/00 ,  A61M35/003 ,  A61M2210/04 ,  B65D83/207 ,  B65D83/752 ,  A61K2300/00

Abstract: The present invention relates to a topical spray composition comprising a biologically active vitamin D derivative or analog and a corticosteroid, and its use in the treatment of dermal diseases and conditions.

Abstract translation: 本发明涉及包含生物活性维生素D衍生物或类似物和皮质类固醇的局部喷雾组合物及其在治疗真皮疾病和病症中的用途。