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公开(公告)号：US20100055709A1
公开(公告)日：2010-03-04
申请号：US12610400
申请日：2009-11-02
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/435 , C12Q1/02
CPC分类号： C12Q1/6883 , C07K14/47 , C12Q2600/106 , C12Q2600/156 , G01N33/5008 , G01N33/5011 , G01N33/68 , G01N33/6848 , G01N2800/52
摘要： The present invention relates to methods for determining the potential of a subject to respond to a particular therapeutic agent, by determining the presence of one or more nucleotide or amino acid variants in the β-tubulin gene or protein. Also provided are methods for treating subjects whose potential to respond to a therapeutic agent has been evaluated. For use in the methods of the invention, there are provided variants of the β-tubulin gene. variants of the β-tubulin protein, nucleic acid molecules and agents which bind to the variant β-tubulin nucleic acid molecules and variant β-tubulin protein, respectively, and kits comprising the same.
摘要翻译： 本发明涉及通过确定微管蛋白基因或蛋白质中一种或多种核苷酸或氨基酸变体的存在来确定受试者对特定治疗剂作出反应的潜力的方法。 还提供了用于治疗对治疗剂有响应的潜能的方法。 为了用于本发明的方法，提供了微管蛋白基因的变体。 分别结合变体和微管蛋白核酸分子和变体和微管蛋白的蛋白质的微管蛋白，核酸分子和试剂的变体和包含其的试剂盒。
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公开(公告)号：US20060235059A1
公开(公告)日：2006-10-19
申请号：US10570850
申请日：2004-09-01
IPC分类号： A61K31/427
CPC分类号： A61K45/06 , A61K31/426 , A61K31/427 , A61K2300/00
摘要： The present invention relates to an in vivo regimen for the treatment of a proliferative disease, where an epothilone, is administered in a loading dose followed by at least 1, maintenance doses.
摘要翻译： 本发明涉及一种用于治疗增殖性疾病的体内方案，其中埃坡霉素以负载剂量施用，然后至少1次，维持剂量。
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公开(公告)号：US07091226B2
公开(公告)日：2006-08-15
申请号：US11089269
申请日：2005-03-24
IPC分类号： A01N43/78 , A61K31/425
CPC分类号： A61K31/425
摘要： The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epothilone.
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公开(公告)号：US20050042275A1
公开(公告)日：2005-02-24
申请号：US10937056
申请日：2004-09-09
IPC分类号： A61K9/127 , A61K31/427
CPC分类号： A61K9/127 , A61K9/1271 , A61K31/427
摘要： The present invention provides pharmaceutical liposomal compositions comprising epothilones.
摘要翻译： 本发明提供包含埃坡霉素的药物脂质体组合物。
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公开(公告)号：US06635666B2
公开(公告)日：2003-10-21
申请号：US09925119
申请日：2001-08-09
IPC分类号： A61K31425
CPC分类号： A61K31/425
摘要： The invention relates to the treatment of a proliferative disease, especially according to certain treatment regimens, with an epothilone, especially with epothilone A and more preferably epothilone B; as well as to the treatment of certain cancers with such an epothilone.
摘要翻译： 本发明涉及治疗增殖性疾病，特别是根据某些治疗方案，与埃坡霉素，特别是埃坡霉素A，更优选埃坡霉素B; 以及用这种埃坡霉素治疗某些癌症
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