公开(公告)号：US20110183971A1

公开(公告)日：2011-07-28

申请号：US12934422

申请日：2009-03-27

Applicant: Giovanni Cervi ,  Matteo D'Anello ,  Gianluca Mariano Enrico Papeo ,  Barbara Salom

Inventor： Giovanni Cervi ,  Matteo D'Anello ,  Gianluca Mariano Enrico Papeo ,  Barbara Salom

IPC: A61K31/5377 ,  C40B40/04 ,  C07D487/04 ,  C12N9/99 ,  A61K31/4985 ,  A61P35/00 ,  A61P31/12 ,  A61P31/18 ,  A61P25/00 ,  A61P35/02

CPC classification number: C07D487/04

Abstract: Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract translation: 公开了3,4-二氢-2H-吡嗪并[1,2-a]吲哚-1-酮衍生物或其药学上可接受的盐，其制备方法和包含它们的药物组合物的化合物。 这些化合物可用于治疗由改变的蛋白激酶活性引起的和/或与其相关的疾病，例如癌症，病毒感染，HIV感染个体中的AIDS发展的预防，细胞增殖性疾病，自身免疫和神经变性疾病; 还公开了用于制备本发明化合物的固相合成条件和包含多个化合物的化学文库的方法。

公开(公告)号：US07728140B2

公开(公告)日：2010-06-01

申请号：US11020793

申请日：2004-12-23

Applicant: Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

Inventor： Barbara Salom ,  Matteo D'Anello ,  Maria Gabriella Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Arthur Brookfield ,  William John Trigg ,  Edward Andrew Boyd ,  Jonathan Anthony Larard

IPC: C07D471/02

CPC classification number: C07D471/04

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

Abstract translation: 公开了吡咯并[2,3-b]吡啶衍生物或其药学上可接受的盐的化合物，其制备方法和包含它们的药物组合物; 这些化合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。 还公开了在SPS条件下制备本发明化合物的方法和包含其中多个化合物的化学文库。

公开(公告)号：US07485661B2

公开(公告)日：2009-02-03

申请号：US11037986

申请日：2005-01-18

Applicant: Roberto Tonani ,  Simona Bindi ,  Daniele Fancelli ,  Valeria Pittala′ ,  Matteo D'Anello

Inventor： Roberto Tonani ,  Simona Bindi ,  Daniele Fancelli ,  Valeria Pittala′ ,  Matteo D'Anello

IPC: A61K31/4162 ,  C07D487/02

CPC classification number: C07D491/04 ,  C07D495/04

Abstract: Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.

Abstract translation: 公开了本说明书中定义的式（I）的双 - 吡唑和其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。

公开(公告)号：US20050256151A1

公开(公告)日：2005-11-17

申请号：US11020793

申请日：2004-12-23

Applicant: Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

Inventor： Barbara Salom ,  Matteo D'Anello ,  Maria Brasca ,  Patrizia Giordano ,  Katia Martina ,  Francesco Angelucci ,  Frederick Brookfield ,  William Trigg ,  Edward Boyd ,  Jonathan Larard

IPC: C07D471/04 ,  G01N33/53 ,  A61K31/4745 ,  C07D471/02

CPC classification number: C07D471/04

Abstract: Compounds which are pyrrolo[2,3-b]pyridine derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders; also disclosed is a process under SPS conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

公开(公告)号：US6121449A

公开(公告)日：2000-09-19

申请号：US367847

申请日：1999-08-27

Applicant: Achille Panzeri ,  Matteo D'Anello ,  Antonio Longo ,  Marcella Nesi

Inventor： Achille Panzeri ,  Matteo D'Anello ,  Antonio Longo ,  Marcella Nesi

IPC: A61P5/24 ,  A61K31/58 ,  A61P43/00 ,  C07J41/00 ,  C07J71/00 ,  C07J73/00 ,  C07D221/02

CPC classification number: C07J73/005

Abstract: A process for producing a compound of formula (I): ##STR1## wherein the dotted lines - - - independently represent a single or double bond and R, R.sub.1, R.sub.2 and R.sub.3 are each hydrogen or an organic radical, comprises treating the corresponding 17.beta.-carbonylimidazole intermediates with anhydrous acids in the presence of an amine and, optionally, hydrogenating the resulting compound.

Abstract translation: PCT No.PCT / EP98 / 08527 Sec。 371日期1999年8月27日第 102（e）1999年8月27日PCT 1998年12月17日PCT PCT。 公开号WO99 /​​ 35161 日期1999年7月15日制备式（I）化合物的方法：其中虚线 - - - 独立地表示单键或双键，并且R，R 1，R 2和R 3各自为氢或有机基团， 在胺的存在下与无水酸反应，并任选地将所得化合物氢化，得到相应的17β-羰基咪唑中间体。

公开(公告)号：US5241090A

公开(公告)日：1993-08-31

申请号：US885856

申请日：1992-05-20

Applicant: Fabrizio Orzi ,  Antonio Longo ,  Matteo D'Anello ,  Natale Barbugian

Inventor： Fabrizio Orzi ,  Antonio Longo ,  Matteo D'Anello ,  Natale Barbugian

IPC: C07J41/00 ,  C07J71/00

CPC classification number: C07J41/0094 ,  C07J41/0011 ,  C07J41/0022 ,  C07J71/001

Abstract: 4-amino-unsaturated androstanedione derivatives provided with aromatase inhibitory activity are obtained by hydrolyzation of a corresponding compound of formula II ##STR1##

Abstract translation: 通过水解相应的式II化合物（II）得到具有芳香酶抑制活性的4-氨基 - 不饱和雄甾二醇衍生物