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公开(公告)号：US08017643B2
公开(公告)日：2011-09-13
申请号：US12840425
申请日：2010-07-21
IPC分类号： A61K31/4162
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.
摘要翻译： 本说明书中定义的式（I）的双 - 吡唑化合物及其药学上可接受的盐，其制备方法，包含其中的多个组合文库及其药物组合物，本文公开了本发明化合物， 在治疗中，作为蛋白激酶抑制剂，例如用于治疗癌症。
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公开(公告)号：US20060160874A1
公开(公告)日：2006-07-20
申请号：US11037986
申请日：2005-01-18
IPC分类号： A61K31/4162 , C07D487/02 , C07D491/02 , C07D498/02
CPC分类号： C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
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公开(公告)号：US07786048B2
公开(公告)日：2010-08-31
申请号：US12472513
申请日：2009-05-27
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.
摘要翻译： 本说明书中定义的式（I）的双 - 吡唑化合物及其药学上可接受的盐，其制备方法，包含其中的多个组合文库及其药物组合物，本文公开了本发明的化合物， 在治疗中，作为蛋白激酶抑制剂，例如用于治疗癌症。
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公开(公告)号：US07485661B2
公开(公告)日：2009-02-03
申请号：US11037986
申请日：2005-01-18
IPC分类号： A61K31/4162 , C07D487/02
CPC分类号： C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazoles of formula (I) as defined in the specification, and pharmaceutically acceptable salts thereof, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的双 - 吡唑和其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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![1H-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors](/abs-image/US/2005/08/25/US20050187209A1/abs.jpg.150x150.jpg)
5.发明申请公开(公告)号：US20050187209A1
公开(公告)日：2005-08-25
申请号：US11050360
申请日：2005-02-03
申请人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
发明人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
IPC分类号： A61K31/4162 , C07D495/04 , A61K31/5377 , A61K31/454 , A61K31/496
CPC分类号： C07D495/04 , A61K31/4162
摘要： Thieno[2,3-c]pyrazole derivatives of formula (1) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（1）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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![1H-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors](/abs-image/US/2013/07/09/US08481584B2/abs.jpg.150x150.jpg)
6.发明授权公开(公告)号：US08481584B2
公开(公告)日：2013-07-09
申请号：US13404697
申请日：2012-02-24
申请人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
发明人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
IPC分类号： A61K31/4162 , C07D231/26
CPC分类号： C07D495/04 , A61K31/4162
摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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![1H-THIENO[2,3-C]PYRAZOLE DERIVATIVES USEFUL AS KINASE INHIBITORS](/abs-image/US/2012/06/28/US20120165311A1/abs.jpg.150x150.jpg)
7.发明申请公开(公告)号：US20120165311A1
公开(公告)日：2012-06-28
申请号：US13404697
申请日：2012-02-24
申请人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
发明人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
IPC分类号： A61K31/4162 , A61K31/5377 , A61K31/496 , A61K31/454 , A61P35/00 , A61P25/28 , A61P31/12 , A61P37/06 , A61P17/06 , A61P9/10 , A61P11/00 , A61P13/12 , A61P9/00 , A61P19/02 , A61K31/55 , A61K31/541 , A61N5/00 , C12N9/99
CPC分类号： C07D495/04 , A61K31/4162
摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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![1H-thieno[2,3-c]pyrazole derivatives useful as kinase inhibitors](/abs-image/US/2012/03/20/US08138217B2/abs.jpg.150x150.jpg)
8.发明授权公开(公告)号：US08138217B2
公开(公告)日：2012-03-20
申请号：US11050360
申请日：2005-02-03
申请人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
发明人： Daniele Fancelli , Paola Vianello , Mario Varasi , Simona Bindi , Sergio Vioglio , Dania Tesei
IPC分类号： A61K31/4162 , C07D231/26
CPC分类号： C07D495/04 , A61K31/4162
摘要： Thieno[2,3-c]pyrazole derivatives of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, process for their preparation and pharmaceutical compositions comprising them are disclosed; the compounds of the invention may be useful, in therapy, in the treatment of diseases associated with a disregulated protein kinase activity, like cancer.
摘要翻译： 公开了本说明书中定义的式（I）的噻吩并[2,3-c]吡唑衍生物及其药学上可接受的盐，其制备方法和包含它们的药物组合物; 本发明的化合物在治疗中可用于治疗与失调的蛋白激酶活性相关的疾病，如癌症。
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公开(公告)号：US20100286223A1
公开(公告)日：2010-11-11
申请号：US12840425
申请日：2010-07-21
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.
摘要翻译： 本说明书中定义的式（I）的双 - 吡唑化合物及其药学上可接受的盐，其制备方法，包含其中的多个组合文库及其药物组合物，本文公开了本发明的化合物， 在治疗中，作为蛋白激酶抑制剂，例如用于治疗癌症。
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公开(公告)号：US07541378B2
公开(公告)日：2009-06-02
申请号：US10522250
申请日：2003-07-11
IPC分类号： A61K31/4162 , C07D231/00
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04
摘要： Bicyclo-pyrazole compound of formula (I) and pharmaceutically acceptable salts thereof, as defined in the specification, processes for their preparation, combinatorial libraries comprising a plurality of them and pharmaceutical compositions thereof, are herewith disclosed: the compounds of the invention are useful, in therapy, as protein kinase inhibitors, for instance in the treatment of cancer.
摘要翻译： 本说明书中定义的式（I）的双 - 吡唑化合物及其药学上可接受的盐，其制备方法，包含其中的多个组合文库及其药物组合物，本文公开了本发明的化合物， 在治疗中，作为蛋白激酶抑制剂，例如用于治疗癌症。
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