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17 条记录 (耗时 0.042 秒)

    Aminoindazole derivatives active as kinase inhibitors
    9.
    发明授权
    Aminoindazole derivatives active as kinase inhibitors 有权
    作为激酶抑制剂活性的氨基吲唑衍生物

    公开(公告)号：US07511136B2

    公开(公告)日：2009-03-31

    申请号：US10490189

    申请日：2002-09-19

    申请人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

    发明人： Raffaella Amici ,  Matteo D'Anello ,  Katia Martina ,  Barbara Salom ,  Anna Vulpetti

    IPC分类号： C07D413/00 ,  C07D231/00

    CPC分类号： C07D231/56 ,  C07D403/04 ,  C07D403/12

    摘要： Compounds which are 3-aminoindazole derivatives or pharmaceutically acceptable salts thereof, together with pharmaceutical compositions comprising them are disclosed; these compounds or compositions are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, Alzheimer's disease, viral infections, auto-immune diseases and neurodegenerative disorders.

    摘要翻译： 公开了3-氨基吲唑衍生物或其药学上可接受的盐以及包含它们的药物组合物的化合物; 这些化合物或组合物可用于治疗由改变的蛋白激酶活性如癌症，细胞增殖性疾病，阿尔茨海默病，病毒感染，自身免疫疾病和神经变性疾病引起的和/或与其相关的疾病。

    3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them
    10.
    发明授权
    3,4-dihydro-2H-pyrazino[1,2-A]indol-1-one derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them 有权
    作为激酶抑制剂活性的3,4-二氢-2H-吡嗪并[1,2-A]吲哚-1-酮衍生物，其制备方法和包含它们的药物组合物

    公开(公告)号：US08513241B2

    公开(公告)日：2013-08-20

    申请号：US13482626

    申请日：2012-05-29

    申请人： Giovanni Cervi ,  Matteo D'Anello ,  Gianluca Mariano Enrico Papeo ,  Barbara Salom

    发明人： Giovanni Cervi ,  Matteo D'Anello ,  Gianluca Mariano Enrico Papeo ,  Barbara Salom

    IPC分类号： A61K31/5355 ,  A61K31/501 ,  C07D413/14 ,  C07D241/04

    CPC分类号： C07D487/04

    摘要： Compounds which are 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one derivatives or pharmaceutically acceptable salts thereof, their preparation process and pharmaceutical compositions comprising them are disclosed; these compounds are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, viral infection, prevention of AIDS development in HIV-infected individuals, cell proliferative disorders, autoimmune and neurodegenerative disorders; also disclosed is a process under Solid Phase Synthesis conditions for preparing the compounds of the invention and chemical libraries comprising a plurality of them.

    摘要翻译： 公开了3,4-二氢-2H-吡嗪并[1,2-a]吲哚-1-酮衍生物或其药学上可接受的盐，其制备方法和包含它们的药物组合物的化合物。 这些化合物可用于治疗由改变的蛋白激酶活性引起的和/或与其相关的疾病，例如癌症，病毒感染，HIV感染个体中的AIDS发展的预防，细胞增殖性疾病，自身免疫和神经变性疾病; 还公开了用于制备本发明化合物的固相合成条件和包含多个化合物的化学文库的方法。