公开(公告)号：US08744571B2

公开(公告)日：2014-06-03

申请号：US12755139

申请日：2010-04-06

Applicant: Peng-Sheng Chen ,  Shengmei Zhou

Inventor： Peng-Sheng Chen ,  Shengmei Zhou

IPC: A61N1/00 ,  A61B5/04

CPC classification number: A61B5/4094 ,  A61B5/04001 ,  A61B5/4035 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/362 ,  A61N1/3702 ,  A61N1/37258 ,  A61N1/37282

Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

Abstract translation: 提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性增加与患者交感神经放电升高相关。 方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。 所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。 可用于与递送有关的药理学试剂包括已知能发挥抗心律不齐作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。 其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

公开(公告)号：US20130124031A1

公开(公告)日：2013-05-16

申请号：US13568526

申请日：2012-08-07

Applicant: Tien-Chen CHEN ,  Kai-Sheng LEE ,  Peng-Sheng CHEN

Inventor： Tien-Chen CHEN ,  Kai-Sheng LEE ,  Peng-Sheng CHEN

IPC: G05D1/02

CPC classification number: G05D1/0225 ,  G05D2201/0215

Abstract: A method of navigating an autonomous mobile device to a base station is provided. In the method, when a detector detects a navigating signal sent out by the base station, the mobile device rotates in a first direction until the detector fails to detect the navigating signal, and a first time point is set at this time. Then, the mobile device rotates in a second direction opposite to the first direction until the detector fails to detect the navigating signal, and a second time point is set at this time. Afterward, the mobile device rotates in the first direction by a time computed based on the first and second time points to make the detector face the base station, and then, moves toward a direction pointed by the detector.

Abstract translation: 提供了一种将自主移动设备导航到基站的方法。 在该方法中，当检测器检测到由基站发出的导航信号时，移动设备沿第一方向旋转，直到检测器不能检测到导航信号，并且此时设置了第一时间点。 然后，移动装置沿着与第一方向相反的第二方向旋转，直到检测器未能检测到导航信号，此时设定第二时间点。 之后，移动设备在第一方向上旋转基于第一和第二时间点计算的时间，以使检测器面向基站，然后朝向检测器指向的方向移动。

公开(公告)号：US20100268289A1

公开(公告)日：2010-10-21

申请号：US12755139

申请日：2010-04-06

Applicant: Peng-Sheng Chen ,  Shengmei Zhou

Inventor： Peng-Sheng Chen ,  Shengmei Zhou

IPC: A61N1/00 ,  A61M37/00

CPC classification number: A61B5/4094 ,  A61B5/04001 ,  A61B5/4035 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/362 ,  A61N1/3702 ,  A61N1/37258 ,  A61N1/37282

Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

Abstract translation: 提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性与增加的交感神经放电相关的增加的可能性。 方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。 所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。 可用于与递送有关的药理学试剂包括已知能发挥抗心律失常作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。 其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

公开(公告)号：US07725178B2

公开(公告)日：2010-05-25

申请号：US11205923

申请日：2005-08-16

Applicant: Peng-Sheng Chen ,  Shengmei Zhou

Inventor： Peng-Sheng Chen ,  Shengmei Zhou

IPC: A61N1/08

CPC classification number: A61B5/4094 ,  A61B5/04001 ,  A61B5/4035 ,  A61N1/0551 ,  A61N1/36114 ,  A61N1/362 ,  A61N1/3702 ,  A61N1/37258 ,  A61N1/37282

Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia, myocardial ischemia, congestive heart failure and other diseased conditions of the heart associated with elevated sympathetic neural discharges in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the stellate ganglia, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenytoin, carbamazepine, valproate, and phenobarbitone. Other pharmacologic agents may be used to treat impending myocardial ischemia and other diseased conditions of the heart associated with elevated sympathetic neural discharges.

Abstract translation: 提供了方法和系统，用于确定患者心脏心律失常，心肌缺血，充血性心力衰竭和其他患病状况升高的可能性与增加的交感神经放电相关的增加的可能性。 方法和系统包括监测来自星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。 所述方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加（例如递送一种或多种药理学试剂）向患者递送治疗; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。 可用于与递送有关的药理学试剂包括已知能发挥抗心律失常作用的药物剂和抗惊厥药如苯妥英，卡马西平，丙戊酸酯和苯巴比妥。 其他药物剂可用于治疗即将出现的心肌缺血以及与交感兴奋神经放电升高相关的其他心脏疾病状况。

公开(公告)号：US20060004413A1

公开(公告)日：2006-01-05

申请号：US10882645

申请日：2004-06-30

Applicant: Peng-Sheng Chen

Inventor： Peng-Sheng Chen

IPC: A61N1/362 ,  A61B5/0402

CPC classification number: A61B5/04001 ,  A61N1/36585 ,  A61N1/37258 ,  A61N1/3962

Abstract: Methods and systems are provided for determining an increased likelihood of the occurrence of a cardiac arrhythmia in a patient. The methods and systems comprise monitoring the sympathetic neural discharges of a patient from the left stellate ganglion, the thoracic ganglia, or both, and detecting increases in the sympathetic neural discharges. The methods and systems may further comprise delivering anti-arrhythmic therapy to the patient in response to a detected increase in the sympathetic neural discharge, such as delivering one or more pharmacological agents; stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient; and applying cardiac pacing, cardioversion or defibrillation shocks. Pharmacologic agents which may be used in connection with the delivery of anti-arrhythmic therapy include those which are known to exert anti-arrhythmic effect and anti-convulsant agents, such as phenyloin, carbamazepine, valproate, and phenobarbitone.

Abstract translation: 提供了用于确定患者心律失常发生的可能性增加的方法和系统。 方法和系统包括监测来自左星状神经节，胸廓神经节或两者的患者的交感神经放电，并检测交感神经放电的增加。 方法和系统可以进一步包括响应于检测到的交感神经排泄物的增加，例如递送一种或多种药理学试剂，向患者递送抗心律失常疗法; 刺激患者心脏的窦房结和右心室的心肌超调; 并应用心脏起搏，心脏复律或除颤电击。 可用于递送抗心律不齐治疗的药理学试剂包括已知发挥抗心律不齐作用的药物剂和抗惊厥剂，如苯ylo嗪，卡马西平，丙戊酸酯和苯巴比妥。

公开(公告)号：US06824538B2

公开(公告)日：2004-11-30

申请号：US10304140

申请日：2002-11-25

Applicant: Peng-Sheng Chen

Inventor： Peng-Sheng Chen

IPC: A61K922

CPC classification number: A61N1/36114

Abstract: A system or apparatus is described for reducing the likelihood of the occurrence of ventricular arrhythmia in the heart of a patient having a myocardial infarction and an atrioventricular block, particularly a ventricular arrhythmia of the type potentially leading to Sudden Cardiac Death. The likelihood of the occurrence of the ventricular arrhythmia is reduced by stimulating myocardial hyperinnervation in the sinus node and right ventricle of the heart of the patient. Myocardial hyperinnervation in the sinus node and right ventricle is stimulated by applying electrical stimulation to the right stellate ganglion of the patient or by applying Nerve Growth Factor or other neurotrophic substance to the right stellate ganglion. The apparatus can also be advantageously exploited for use with patients having myocardial infarction but no atrioventricular block and for patients have other heart conditions such as Brugada syndrome.

Abstract translation: 描述了一种系统或装置，用于降低患有心肌梗死和房室传导阻滞的患者的心脏中的室性心律失常发生的可能性，特别是可能导致突发性心脏死亡的类型的室性心律失常。 通过刺激患者心脏的窦房结和右心室的心肌超调，降低心室心律失常发生的可能性。 通过对患者的右星状神经节施加电刺激或通过将神经生长因子或其他神经营养物质施用于右星状神经节来刺激窦房结和右心室的心肌超调。 该装置还可以有利地被利用用于具有心肌梗塞但不具有房室传导阻滞的患者，并且患者具有其他心脏状况如Brugada综合征。

公开(公告)号：US06353757B2

公开(公告)日：2002-03-05

申请号：US09884212

申请日：2001-06-18

Applicant: Peng-Sheng Chen

Inventor： Peng-Sheng Chen

IPC: A61N100

CPC classification number: A61N1/385 ,  A61N1/36114 ,  A61N1/3956

Abstract: A method is described for increasing the likelihood of the occurrence of an arrhythmia in a heart, particularly a ventricular arrhythmia of the type leading to Sudden Cardiac Death. The method includes the steps of creating an atrioventricular block in the heart of an animal test subject, inducing a myocardial infarction in the heart of the test subject, and then stimulating myocardial hyperinnervation the test subject. In a specific example described herein, the atrioventricular block is created by ablating the atrioventricular node of the heart using an ablation catheter. The myocardial infarction is induced by ligating the left anterior descending portion of the coronary artery. Myocardial hyperinnervation is stimulated by application of Nerve Growth Factor or other neurotrophic vectors to the left stellate ganglion. The test subject is an adult canine. By creating an atrioventricular block and a myocardial infarction within the heart of an adult canine test subject, then stimulating nerve growth within the left stellate ganglion of the subject using Nerve Growth Factor, it has been found that there is a significant increase in the likelihood of Sudden Cardiac Death arising from ventricular arrhythmias. It is believed that the Sudden Cardiac Death of the test subject arises in a manner very similar to circumstances wherein Sudden Cardiac Death occurs in human patients subject to a previous myocardial infarction, thus, an animal model system for artificially inducing a heart arrhythmia is also disclosed. Thus, the method and animal model system facilitate the collection of data pertinent to conditions within the heart arising prior to Sudden Cardiac Death and for developing and testing therapies intended to prevent Sudden Cardiac Death.

Abstract translation: 描述了一种用于增加心脏中发生心律失常的可能性的方法，特别是导致突发性心脏死亡的类型的室性心律失常。 该方法包括以下步骤：在动物测试对象的心脏中产生房室传导阻滞，在测试对象的心脏中诱发心肌梗死，然后刺激心脏超嗜化的测试对象。 在本文所述的具体示例中，通过使用消融导管消融心脏房室结而产生房室传导阻滞。 通过结扎冠状动脉的左前降支部分诱导心肌梗塞。 通过将神经生长因子或其他神经营养载体应用于左星状神经节来刺激心肌过度增生。 测试对象是成年犬。 通过在成年犬试验对象的心脏内产生房室传导阻滞和心肌梗塞，然后使用神经生长因子刺激受试者的左星状神经节内的神经生长，已经发现，可能性显着增加 心室心跳骤停引起心室心律失常。 据信，测试对象的突发性心脏死亡以非常类似于在先前心肌梗塞的人类患者中发生突发性心脏死亡的情况的方式产生，因此，还公开了人造诱发心律失常的动物模型系统 。 因此，方法和动物模型系统有助于收集与突发性心脏死亡之前产生的心脏内的情况相关的数据，并开发和测试旨在预防突发性心脏死亡的疗法。

公开(公告)号：US5817132A

公开(公告)日：1998-10-06

申请号：US854217

申请日：1997-05-09

Applicant: Hrayr S. Karagueuzian ,  Peng-Sheng Chen

Inventor： Hrayr S. Karagueuzian ,  Peng-Sheng Chen

IPC: A61N1/39

CPC classification number: A61N1/39 ,  A61N1/3956 ,  A61N1/3987

Abstract: An implanted defibrillator continuously monitors a patient's heart to detect the presence of fibrillation and repeatedly, automatically computes the approximate entropy of a series of data representing the fibrillating heart at a moment in time. The first approximate entropy score that meets a predetermined relation with respect to a predetermined threshold value activates an energy delivery system to defibrillate the heart with a low level shock. The process continues until defibrillation is successful. An external defibrillator incorporates the approximate entropy algorithm to achieve low level defibrillation. A method is disclosed which times the delivery of a defibrillating shock to a fibrillating heart to coincide with the moment that the defibrillation threshold is at a minimum.

Abstract translation: 植入式除颤器连续监测患者的心脏以检测原纤维的存在并重复地自动计算一段时间内代表原纤维心脏的一系列数据的近似熵。 满足相对于预定阈值的预定关系的第一近似熵分数激活能量递送系统以以低水平的震动去除心脏。 该过程持续到除颤成功。 外部除颤器结合近似熵算法来实现低水平除颤。 公开了一种将除颤冲击递送到原纤化心脏以与除颤阈值最小的时刻相一致的方法。

公开(公告)号：USRE35880E

公开(公告)日：1998-08-25

申请号：US518355

申请日：1995-08-13

Applicant: Lewis K. Waldman ,  Peng-Sheng Chen

Inventor： Lewis K. Waldman ,  Peng-Sheng Chen

IPC: A61B5/042

CPC classification number: A61B5/6859 ,  A61B5/0422

Abstract: An endocardial mapping catheter .�.for locating the ectopic focus of an abnormally functioning heart includes an actuator assembly and an elongated hollow support sheath which extends from the actuator assembly. A plurality of electrical probes are slidingly disposed for independent movement through the sheath, and each probe is attached to the actuator assembly for individual manipulation. A guide is mounted on the end of the sheath opposite the actuator assembly, at the distal end of the sheath, to radially deploy each electrical probe along a separate favorable trajectory as the probe is manipulated to move distally through the sheath. In operation, the probes are initially retracted into the sheath as the guide is positioned inside the left ventricle of the heart. Once the guide is positioned as desired, all of the probes are individually deployed until they have each made contact with the endocardium of the left ventricle. Timed responses are obtained from the probes, and a series of such responses from various guide locations in the left ventricle are recorded to accomplish circumferential endocardial mapping of the heart..!. .Iadd.comprising an elongate flexible support sheath having a proximal end and a distal end and a plurality of electrical probes. Each of the probes has a proximal end and a distal end and is slidably disposed in the support sheath. A guide is disposed on the distal end of the support sheath and has a plurality of passageways. Each of the passageways separately receives one of the probes and is formed with a surface having an arcuately extending distal portion. Actuators are carried by the proximal ends of the probes for deploying the distal ends of the probes from the support sheath. The arcuately extending distal portion of each surface serves to radially deploy the distal end of a probe from the guide along a favorable trajectory from the guide as the probe is individually moved distally through the support sheath..Iaddend.

公开(公告)号：US5237996A

公开(公告)日：1993-08-24

申请号：US833746

申请日：1992-02-11

Applicant: Lewis K. Waldman ,  Peng-Sheng Chen

Inventor： Lewis K. Waldman ,  Peng-Sheng Chen

IPC: A61B5/042

CPC classification number: A61B5/6859 ,  A61B5/0422

Abstract: An endocardial mapping catheter for locating the ectopic focus of an abnormally functioning heart includes an actuator assembly and an elongated hollow support sheath which extends from the actuator assembly. A plurality of electrical probes are slidingly disposed for independent movement through the sheath, and each probe is attached to the actuator assembly for individual manipulation. A guide is mounted on the end of the sheath opposite the actuator assembly, at the distal end of the sheath, to radially deploy each electrical probe along a separate favorable trajectory as the probe is manipulated to move distally through the sheath. In operation, the probes are initially retracted into the sheath as the guide is positioned inside the left ventricle of the heart. Once the guide is positioned as desired, all of the probes are individually deployed until they have each made contact with the endocardium of the left ventricle. Timed responses are obtained from the probes, and a series of such responses from various guide locations in the left ventricle are recorded to accomplish circumferential endocardial mapping of the heart.

Abstract translation: 用于定位异常功能心脏的异位焦点的心内膜测绘导管包括致动器组件和从致动器组件延伸的细长的中空支撑护套。 多个电探针被滑动地布置成用于通过护套的独立移动，并且每个探针附接到致动器组件用于单独操作。 引导件安装在与致动器组件相对的护套的端部处，在护套的远端处，当探头被操纵以沿远端移动穿过护套时，沿着单独的有利轨迹沿径向展开每个电探头。 在操作中，当引导件位于心脏的左心室内时，探针最初缩回到护套中。 一旦根据需要定位指南，所有的探针被单独地展开，直到它们各自与左心室的心内膜接触。 从探针获得定时反应，并记录来自左心室各种指导位置的一系列这样的反应以完成心脏的周围心内膜作图。