Uncaging devices
    22.
    发明授权
    Uncaging devices 有权
    取消启动设备

    公开(公告)号:US07551271B2

    公开(公告)日:2009-06-23

    申请号:US11893012

    申请日:2007-08-13

    CPC classification number: G01N21/6452

    Abstract: Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.

    Abstract translation: 提供了可用于解除可光灭活的笼式组件的非屏蔽设备。 提供了包括笼式组件的反应和测定的一致,均匀和/或高通量处理。 提供可用于解码可光致灭活笼式组件的蒙版多孔板。 提供了用于启动包含笼式组件的测定的方法和装置。

    Drill bit arcuate-shaped inserts with cutting edges and method of manufacture
    23.
    发明授权
    Drill bit arcuate-shaped inserts with cutting edges and method of manufacture 失效
    钻头圆弧形刀片和切削刃和制造方法

    公开(公告)号:US07331410B2

    公开(公告)日:2008-02-19

    申请号:US10923653

    申请日:2004-08-20

    CPC classification number: E21B10/50 E21B10/16

    Abstract: Disclosed are a variety of arcuate-shaped inserts for drill bits, and in particular, for placement in rolling cone cutters of drill bits. The arcuate inserts include 360° or ring-shaped inserts, as well as inserts of smaller arcuate length. The arcuate inserts are suitable for use in all surfaces of the rolling cone cutter, and in other locations in drill bits, and may have specialized cutting surfaces and material enhancements to enhance their cutting duty performance. Certain arcuate inserts may include stress relieving discontinuities such that, upon assembly into the cone or during drilling, the arcuate inserts may fragment in a controlled and predicted manner into shorter arcuate lengths.

    Abstract translation: 公开了用于钻头的各种弧形插入件,特别地,用于放置在钻头的滚动锥形切割器中。 弧形刀片包括360°或环形刀片,以及较小弓形长度的刀片。 弧形插入件适用于滚动圆锥切割机的所有表面,以及钻头中的其他位置,并且可具有专门的切割表面和材料增强功能,以增强其切割性能。 某些弓形刀片可包括应力消除不连续性,使得在组装到锥体中或在钻孔期间,弓形刀片可以以受控和预测的方式分段成较短的弓形长度。

    Assay system for simultaneous detection and measurement of multiple modified cellular proteins

    公开(公告)号:US20060166298A1

    公开(公告)日:2006-07-27

    申请号:US11392061

    申请日:2006-03-28

    CPC classification number: G01N33/6842 G01N33/6803 G01N33/6854 Y10S435/973

    Abstract: A method and kit for simultaneous detection and/or determination of a plurality of modified proteins in a sample. The method comprises: a) contacting the sample under mild protein denaturation conditions with a plurality of first antibodies capable of binding to a specific target protein, the first antibodies being immobilized on solid support material, each first antibody being differentiable from others by a differentiation parameter, whereby the first antibodies bind to respective target proteins present in the sample; b) removing unbound materials from the locus of the first antibodies; c) contacting the materials from step (b) with one or more second antibodies, each of which is specific to a class or subclass of modified proteins or with a plurality of second antibodies, each of which is specific to a modified protein, so as to bind the second antibody or antibodies to modified proteins in the sample; and d) detecting and/or determining a plurality of modified proteins in the sample. The kit comprises a plurality of primary antibodies immobilized on the above-mentioned solid support material, one or more buffers for lysing and for washing cellular material samples to be assayed, an assay buffer for conducting the assay, the buffer containing a sulfate or sulfonate detergent, and one or more second antibodies specific to the modified proteins. Also disclosed is a process for mild denaturation of modified proteins for use in such a procedure.

    REVENUE MANAGEMENT SYSTEM AND ASSOCIATED METHOD
    25.
    发明申请
    REVENUE MANAGEMENT SYSTEM AND ASSOCIATED METHOD 有权
    收入管理制度及相关方法

    公开(公告)号:US20120310706A1

    公开(公告)日:2012-12-06

    申请号:US13171010

    申请日:2011-06-28

    CPC classification number: G06Q10/02 G06Q30/06

    Abstract: A revenue management system comprising a first revenue management route which includes a forecast module and an optimization module and which calculates expected revenue for sales of inventory items based on historical data; a second revenue management route which is selected if the confidence in the forecasting in the first route is below a predetermined value.

    Abstract translation: 一种收入管理系统,包括:第一收入管理路线,其包括预测模块和优化模块,并且根据历史数据计算库存物品的销售的预期收入; 如果对第一路线中的​​预测的置信度低于预定值,则选择第二收入管理路线。

    WATCH DISPLAY ASSEMBLY
    26.
    发明申请
    WATCH DISPLAY ASSEMBLY 失效
    手表显示组件

    公开(公告)号:US20120201106A1

    公开(公告)日:2012-08-09

    申请号:US13359052

    申请日:2012-01-26

    CPC classification number: A47F5/025 A47F7/022

    Abstract: Watch display assembly including a watch support element (2), characterized in that the support element (2) is arranged to rotate on two perpendicular axes (X-X; Y-Y).

    Abstract translation: 手表显示组件,包括手表支撑元件(2),其特征在于,所述支撑元件(2)布置成在两个垂直轴线(X-X; Y-Y)上旋转。

    Caged sensors, regulators and compounds and uses thereof
    27.
    发明授权
    Caged sensors, regulators and compounds and uses thereof 有权
    笼式传感器,调节器和化合物及其用途

    公开(公告)号:US07541193B2

    公开(公告)日:2009-06-02

    申请号:US10716174

    申请日:2003-11-17

    Abstract: A number of caged (e.g., photoactivatable) compositions are provided, for example, caged enzyme sensors, caged binding sensors, caged nucleic acid probes, caged interfering RNAs, caged antisense nucleic acids, caged ribozymes, caged biomolecular analogs, caged transcription factors, caged antibodies, caged molecular decoys, and caged aptamers. Compositions comprising a plurality of caged components are also provided, as are labeled and optionally caged modulators. Also provided are kits for making the caged compositions and methods for making and for using the caged compositions. Related systems and devices are also provided (e.g., an uncaging device that can trigger photoactivatable assays and optionally detect signals from the assays).

    Abstract translation: 提供了许多笼状(例如,可光活化的)组合物,例如笼式酶传感器,笼式结合传感器,笼式核酸探针,笼式干扰RNA,笼式反义核酸,笼式核酶,笼式生物分子类似物,笼状转录因子,笼养 抗体,笼状分子诱饵和笼状适体。 还提供了包括多个笼状组分的组合物,如标记的和任选的笼式调节剂。 还提供了用于制备笼形组合物和制备和使用笼形组合物的方法的试剂盒。 还提供了相关系统和装置(例如,能够触发可光活化测定并且可选地检测来自测定的信号的解开装置)。

    Uncaging device
    28.
    发明授权
    Uncaging device 有权
    无效设备

    公开(公告)号:US07271886B2

    公开(公告)日:2007-09-18

    申请号:US10716176

    申请日:2003-11-17

    CPC classification number: G01N21/6452

    Abstract: Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.

    Abstract translation: 提供了可用于解除可光灭活的笼式组件的非屏蔽设备。 提供了包括笼式组件的反应和测定的一致,均匀和/或高通量处理。 提供了可用于解码可光致灭活笼式组件的蒙版多孔板。 提供了用于启动包含笼式组件的测定的方法和装置。

    Caged RNAs and methods of use thereof
    29.
    发明申请
    Caged RNAs and methods of use thereof 审中-公开
    笼状RNA及其使用方法

    公开(公告)号:US20050282203A1

    公开(公告)日:2005-12-22

    申请号:US11134851

    申请日:2005-05-17

    CPC classification number: G01N21/6452

    Abstract: Methods of using labeled interfering RNAs to detect and/or quantitate target mRNAs in cells are provided. Related compositions, systems, and kits are also provided. Caged interfering RNAs (e.g., photoactivatable interfering RNAs), methods of using such caged RNAs, and related systems and kits are also provided. Caged RNAs capable of repressing translation of a target mRNA or silencing transcription of a target gene are also provided, along with related methods, systems, and kits. Methods and compositions for introducing RNAs into cells, using RNAs covalently associated with protein transduction domains and/or lipids, are provided. Also provided are methods and compositions for selectively attenuating expression of a target mRNA by controlling expression of an interfering RNA, an RNA capable of initiating translation repression, or an RNA capable of initiating transcriptional silencing.

    Abstract translation: 提供了使用标记的干扰RNA来检测和/或定量细胞中靶mRNA的方法。 还提供了相关的组合物,系统和试剂盒。 还提供了笼式干扰RNA(例如可光活化干扰RNA),使用这种笼式RNA的方法以及相关系统和试剂盒。 还提供能够抑制靶mRNA翻译或沉默靶基因转录的笼状RNA以及相关方法,系统和试剂盒。 提供了使用与蛋白质转导结构域和/或脂质共价缔合的RNA将RNA引入细胞的方法和组合物。 还提供了通过控制干扰RNA的表达,能够启动翻译抑制的RNA或能够启动转录沉默的RNA来选择性减弱靶mRNA表达的方法和组合物。

    Uncaging device
    30.
    发明申请
    Uncaging device 有权
    无效设备

    公开(公告)号:US20050051706A1

    公开(公告)日:2005-03-10

    申请号:US10716176

    申请日:2003-11-17

    CPC classification number: G01N21/6452

    Abstract: Uncaging devices that can be used to uncage photoactivatable caged components are provided. Consistent, uniform and/or high throughput processing of reactions and assays that include caged components is provided. Masked multiwell plates that can be used for uncaging photoactivatable caged components are provided. Methods and apparatus for initiating assays involving caged components are provided.

    Abstract translation: 提供了可用于解除可光灭活的笼式组件的非屏蔽设备。 提供了包括笼式组件的反应和测定的一致,均匀和/或高通量处理。 提供了可用于解码可光致灭活笼式组件的蒙版多孔板。 提供了用于启动包含笼式组件的测定的方法和装置。

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