公开(公告)号：US20210000794A1

公开(公告)日：2021-01-07

申请号：US16982523

申请日：2019-02-26

Applicant: Showa University ,  TMS Co., Ltd.

Inventor： Terumasa Hashimoto ,  Keita Shibata ,  Kazuo Honda ,  Koji Nobe

IPC: A61K31/407 ,  A61P13/12

Abstract: A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.

公开(公告)号：US20200029898A1

公开(公告)日：2020-01-30

申请号：US16384029

申请日：2019-04-15

Applicant: SEIKO INSTRUMENTS INC. ,  SHOWA UNIVERSITY

Inventor： Shunji WATANABE ,  Yoshifumi Yoshida ,  Kotaro Maki

IPC: A61B5/00 ,  A61B5/1455 ,  A61B5/145 ,  A61B5/024

Abstract: A biometric information detection device according to one embodiment of the present disclosure is configured to be installed in a living body, and includes a sensor, a battery, a mechanical switch, a sealing member, and a holding member. The mechanical switch switches between a conduction state in which power is supplied from the battery to the sensor and a cutoff state in which supply of the power is blocked. The sealing member seals all of the sensor, the battery, and the mechanical switch. The holding member is attached to the living body and holds the sealing member.

公开(公告)号：US20250099427A1

公开(公告)日：2025-03-27

申请号：US18914718

申请日：2024-10-14

Applicant: Showa University ,  Corxel Pharmaceuticals Hong Kong Limited

Inventor： Terumasa Hashimoto ,  Keita Shibata ,  Kazuo Honda ,  Koji Nobe

IPC: A61K31/407 ,  A61P13/12

Abstract: A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.

公开(公告)号：US12138244B2

公开(公告)日：2024-11-12

申请号：US16982523

申请日：2019-02-26

Applicant: Showa University ,  Ji Xing Pharmaceutical Hong Kong Limited

Inventor： Terumasa Hashimoto ,  Keita Shibata ,  Kazuo Honda ,  Koji Nobe

IPC: A61K31/407 ,  A61P13/12

Abstract: A drug for renal disease, the drug including a compound represented by the following Formula (I) as an active ingredient.

公开(公告)号：US20210188841A1

公开(公告)日：2021-06-24

申请号：US16650133

申请日：2018-09-27

Applicant: KAGOSHIMA UNIVERSITY ,  SHOWA UNIVERSITY

Inventor： Takashi KURIHARA ,  Ichiro TAKASAKI ,  Naoki TOYOOKA ,  Hiroaki GOUDA

IPC: C07D471/04 ,  C07D403/14

Abstract: This invention relates to an analgesic drug comprising a compound represented by the following formula (I) or (II), wherein R1 is a C1-6-alkoxy group or a C1-6-haloalkoxy group; R2 is a hydrogen atom; and R is an indazolyl group substituted with a halogen atom; a substituted or unsubstituted phenyl group; a pyrazolyl group; or a substituted or unsubstituted aralkyl group; or a salt thereof, or a solvate thereof.

公开(公告)号：US20210022586A1

公开(公告)日：2021-01-28

申请号：US17046233

申请日：2019-04-12

Applicant: Showa University ,  National University Corporation Tokai National Higher Education and Research System

Inventor： Yuichi MORI ,  Shin-ei KUDO ,  Masashi MISAWA ,  Kensaku MORI

IPC: A61B1/00 ,  A61B1/045

Abstract: An endoscope observation assistance apparatus includes an image information acquiring part to acquire and display a captured image of a luminal organ captured by the endoscope device on a display, a lesion information acquisition part to detect a predetermined lesion based on the captured image and to acquire lesion information regarding the lesion, a lesion disappearance determination part to track the lesion based on the captured image and the lesion information and to determine whether or not the lesion has disappeared from the captured image, and a notification part to notify a determination result when the lesion disappearance determination part determines that the lesion has disappeared from the captured image. Alternatively, the notification part may notify a lesion detection when a short time period passes after the lesion detection by the lesion information acquisition part.

公开(公告)号：US20150044663A1

公开(公告)日：2015-02-12

申请号：US14303437

申请日：2014-06-12

Applicant: Showa University

Inventor： Masanori Nakamura ,  Shunichi Kuroda ,  Mitsuo Oda ,  Mitsuori Mayahara ,  Sachiyo Kenmotsu ,  Koichi Igarashi ,  Kazunori Oie

IPC: A01N1/02 ,  C12N5/0789

CPC classification number: A01N1/0226 ,  A61K35/12 ,  A61K38/00 ,  A61L27/3604 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/414 ,  A61L2430/40 ,  C07K14/51 ,  C12N5/0647

Abstract: The object aims to form and maintain a cell, a tissue or an organ induced by differentiation. Disclosed is a composition for inducing the differentiation of a cell capable of being differentiated in a given direction to thereby produce a cell, a tissue or an organ through the further induction of the differentiation in the given direction. The composition comprises NELL-1 or a substance which can be altered so as to act as NELL-1 upon the differentiation. Also disclosed is a composition for maintaining a cell, a tissue or an organ produced by the induction of the differentiation.

Abstract translation: 该目的是形成和维持由分化诱导的细胞，组织或器官。 公开了用于诱导能够在给定方向上分化的细胞分化的组合物，从而通过进一步诱导给定方向的分化来产生细胞，组织或器官。 组合物包含NELL-1或可以改变以在分化时作为NELL-1的物质。 还公开了用于维持通过诱导分化产生的细胞，组织或器官的组合物。