METHOD FOR IMPROVING THROUGHPUT OF COMPOUND-PROTEIN INTERACTION EXPERIMENTS

    公开(公告)号:US20250095772A1

    公开(公告)日:2025-03-20

    申请号:US18579798

    申请日:2023-06-05

    Abstract: The present application provides a method for improving a throughput of compound-protein interaction experiments. In the method of this application, multiple compounds to be tested are composed into multiple mixture systems according to a certain mixing rule, and corresponding relationships between abilities of the compounds to be tested to interact with the protein target and the mixture systems are established, and then the target protein corresponding to the compound to be tested is analyzed in a high-throughput manner. The analysis method of the present application can increase a detection throughput of the existing compound to be tested-target protein experiments by more than 10 times, while saving more than 90% of the experimental cost and time, significantly reducing the cost of manpower, time and experimental consumables, which has significant economic significance.

    Receptor material, synthesis method and use thereof

    公开(公告)号:US20240334824A1

    公开(公告)日:2024-10-03

    申请号:US18623301

    申请日:2024-04-01

    CPC classification number: H10K85/657 C07D495/22 H10K85/626 H10K30/50

    Abstract: A receptor material, a synthesis method and use thereof is disclosed. The synthesis method of the receptor material includes: S1, reacting the compound shown in a formula I with LiAlH4 to obtain a compound shown in a formula II; S2, reacting the compound shown in the formula II with 1,10-phenanthroline-5,6-dione to obtain a compound shown in a formula III; S3, reacting the compound shown in the formula III with phosphorus oxychloride and N,N-dimethylformamide to obtain a compound shown in a formula IV; and S4, reacting the compound shown in the formula IV with (5,6-dihalo-3-oxo-2,3-dihydro-1H-inden-1-ylidene)malononitrile. The receptor material provided by the present disclosure can effectively improve the open-circuit voltage and photoelectric conversion efficiency of organic photovoltaics cells including the receptor material. The present disclosure further provides an organic photovoltaic cell including the above receptor material and a method for preparing the organic photovoltaic cell.

    Optimization method, apparatus, computer device and storage medium for engine model

    公开(公告)号:US11704604B2

    公开(公告)日:2023-07-18

    申请号:US17878287

    申请日:2022-08-01

    CPC classification number: G06Q10/04 G06F17/11

    Abstract: An optimization method, apparatus, computer device and storage medium for engine model. The method includes: setting an initial population according to a predetermined number of solutions; obtaining a first output set of the initial population on the engine model; determining a first fitness value; operating selection, crossover, and mutation on the initial population according to the first fitness value to obtain an evolved population, and the initial population and the evolved population constitute a to-be-selected population; obtaining a second output set of the evolved population on the engine model; determining a second fitness value; selecting engine model parameters in the to-be-selected population to form a new population according to the second fitness value; and optimizing the engine model by using the engine model parameters in the new population if a termination condition is met.

    Evaluation method for impact of emission control on air quality, device and storage medium thereof

    公开(公告)号:US11592428B2

    公开(公告)日:2023-02-28

    申请号:US16897063

    申请日:2020-06-09

    Inventor: Ying Li Yushan Song

    Abstract: An atmospheric pollution emission control effect evaluation method, device and storage medium, including: carrying out meteorological condition frequency statistics of data collected from meteorological station, obtaining meteorological condition frequency distribution information; obtaining pollutant concentration information, performing pollutant concentration distribution statistics to obtain pollution concentration distribution information and pollution concentration variation information; decomposing effects of meteorological factors and non-meteorological factors according to meteorological condition frequency distribution information, pollution concentration distribution information and pollution concentration variation information, to obtain meteorological and non-meteorological contribution information; constructing source emission control effect evaluation data set according to meteorological condition frequency distribution information, pollution concentration distribution information, meteorological and non-meteorological contribution information. Accordingly, emission control effect can be quantitatively evaluated based on observation data. Emission increasing effect and contribution of meteorological changes to variation of average pollution level can be quantified.

    BILATERAL LIMB COORDINATION TRAINING SYSTEM AND CONTROL METHOD

    公开(公告)号:US20230044898A1

    公开(公告)日:2023-02-09

    申请号:US17790919

    申请日:2020-04-02

    Abstract: Provided are a bilateral limb coordination training system and a bilateral limb coordination training control method. The bilateral limb coordination training control method includes: detecting, by a force sensor, force information of a three degree-of-freedom bilateral motion mechanism and sending the force information to a main controller; determining, by the main controller, target motion information of the three degree-of-freedom bilateral motion mechanism of a robot according to the force information; and controlling, by the main controller, the three degree-of-freedom bilateral motion mechanism to perform a corresponding motion based on the target motion information and sending training data and running status information generated during training to an upper computer; where a training instruction includes a bilateral non-association motion training instruction, a bilateral flexible-association motion training instruction or a bilateral rigid-association motion training instruction.

    METHOD, APPARATUS, COMPUTER DEVICE, AND STORAGE MEDIUM FOR AUTOMATIC DESIGN OF ANALOG CIRCUITS BASED ON TREE STRUCTURE

    公开(公告)号:US20220414307A1

    公开(公告)日:2022-12-29

    申请号:US17880015

    申请日:2022-08-03

    Inventor: Xinming SHI Xin YAO

    Abstract: A method, apparatus, computer device, and storage medium for automatic design of analog circuits based on tree structure. The method includes: setting the maximum height and growth direction of the tree structure; randomly calling the node from the function node library as the parent node; randomly calling the node from the function node library and the port node library as the child according to the growth direction node; if the child node is a terminal node, generating a tree structure; checking the tree structure, if the tree structure satisfies the preset conditions, obtaining the circuit topology and device parameter that conform to the circuit rules; evolving the circuit topology and device parameter to generate an analog circuit. The embodiments achieve the effect of making the tree structure of the designed analog circuit more reasonable.

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