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    THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN
    23.
    发明申请
    THERAPEUTIC AGENTS USEFUL FOR TREATING PAIN 有权
    治疗药物有用的治疗药物

    公开(公告)号：US20100004254A1

    公开(公告)日：2010-01-07

    申请号：US12499480

    申请日：2009-07-08

    Applicant: Qun Sun ,  Laykea Tafesse ,  Sam Victory

    Inventor： Qun Sun ,  Laykea Tafesse ,  Sam Victory

    IPC: A61K31/501 ,  C07D415/00 ,  C07D403/04 ,  A61K31/497

    CPC classification number: C07D417/12 ,  A61K31/495 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12

    Abstract: A compound of formula: wherein Ar1, A, R3, x, and m are as disclosed herein and Ar2 is a benzothiazolyl, benzooxazolyl, or benzoimidazolyl group or a pharmaceutically acceptable salt thereof (a “Benzoazolylpiperazine Compound”), compositions comprising a Benzoazolylpiperazine Compound, and methods for treating or preventing pain, UI, an ulcer, IBD, IBS, an addictive disorder, Parkinson's disease, parkinsonism, anxiety, epilepsy, stroke, a seizure, a pruritic condition, psychosis, a cognitive disorder, a memory deficit, restricted brain function, Huntington's chorea, amyotrophic lateral sclerosis, dementia, retinopathy, a muscle spasm, a migraine, vomiting, dyskinesia, or depression in an animal comprising administering to an animal in need thereof an effective amount of a Benzoazolylpiperazine Compound are disclosed.

    Abstract translation: 下式的化合物：其中Ar1，A，R3，x和m如本文所公开，Ar 2是苯并噻唑基，苯并恶唑基或苯并咪唑基或其药学上可接受的盐（“苯并恶唑基哌嗪化合物”），包含苯并恶唑基哌嗪化合物 以及用于治疗或预防疼痛，UI，溃疡，IBD，IBS，成瘾性障碍，帕金森病，帕金森综合征，焦虑，癫痫，中风，癫痫发作，瘙痒症状，精神病，认知障碍，记忆缺陷， 限制性脑功能，亨廷顿氏舞蹈病，肌萎缩性侧索硬化，痴呆，视网膜病变，肌肉痉挛，偏头痛，呕吐，运动障碍或抑郁症，其中包括向有需要的动物施用有效量的苯并恶唑基哌嗪化合物。

    Nociceptin analogs
    25.
    发明授权
    Nociceptin analogs 有权
    伤害感受类似物

    公开(公告)号：US07563809B2

    公开(公告)日：2009-07-21

    申请号：US11069728

    申请日：2005-03-01

    Applicant: R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

    Inventor： R. Richard Goehring ,  Zhengming Chen ,  John Whitehead ,  Parviz Gharagozloo ,  Sam Victory ,  Donald Kyle

    IPC: C07D417/04 ,  C07D417/14 ,  A61K31/5415 ,  A61P29/00

    CPC classification number: C07D417/04 ,  C07D401/04

    Abstract: The invention relates to benzothiadiazole compounds of formula (I): and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein R1, R2, A, B, C, W, Z and n are defined as set forth in the specification. The compounds of the invention have affinity for the nociceptin receptor. The invention is also directed to the use of compounds of Formula (I) to treat a disorder responsive to modulation of the nociceptin receptor. Compounds of the present invention are especially useful for treating pain.

    Abstract translation: 本发明涉及式（I）的苯并噻二唑化合物及其药学上可接受的盐，前药或溶剂化物，其中R1，R2，A，B，C，W，Z和n如说明书所述定义。 本发明的化合物对伤害感受肽受体具有亲和力。 本发明还涉及式（I）化合物用于治疗响应于伤害感受肽受体调节的病症的用途。 本发明的化合物特别适用于治疗疼痛。

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