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96 条记录 (耗时 0.043 秒)

    Fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs
    1.
    发明授权
    Fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs 有权
    氟乙基硫胺素或其盐及其在制备抗球虫药物中的应用

    公开(公告)号：US09096581B2

    公开(公告)日：2015-08-04

    申请号：US14401268

    申请日：2013-03-15

    申请人： GUANGZHOU ORIGMOL FEED-ADDITIVE CO., LTD

    发明人： Xianfeng Peng ,  Zonghua Qin ,  Qijun Liu

    IPC分类号： A61K31/51 ,  C07D415/00 ,  C07D417/06 ,  A23K1/16

    CPC分类号： C07D415/00 ,  A23K20/10 ,  A23K20/121 ,  A23K20/137 ,  A23K20/195 ,  A23K50/75 ,  A61K31/51 ,  C07D417/06

    摘要： The present invention discloses a fluoroethyl thiamine or salts thereof and application thereof in preparation of anticoccidial drugs. The structural formula of the fluoroethyl thiamine or salts thereof is shown as Formula (I). The fluoroethyl thiamine or salts thereof of the present invention have a remarkable anticoccidial effect, particularly on some coccidia which had resistance to other anticoccidial drugs, therefore the fluoroethyl thiamine or salts thereof of the present invention can be applied to preparation of anticoccidial drugs. Thus, the present invention provides conditions for development of new anticoccidial drugs.

    摘要翻译： 本发明公开了一种氟乙基硫胺素或其盐及其在制备抗播药药物中的应用。 氟乙基硫胺素或其盐的结构式如式（I）所示。 本发明的氟乙基硫胺素或其盐具有显着的抗球虫作用，特别是对具有抗其它抗球虫药抗性的一些球虫，因此本发明的氟乙基硫胺素或其盐可用于制备抗感冒药。 因此，本发明提供了开发新的抗球虫药物的条件。

    Aminothiazolones as estrogen related receptor-alpha modulators
    2.
    发明授权
    Aminothiazolones as estrogen related receptor-alpha modulators 有权

    公开(公告)号：US08445690B2

    公开(公告)日：2013-05-21

    申请号：US13028284

    申请日：2011-02-16

    申请人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    发明人： Gilles Bignan ,  Micheal Gaul ,  Guozhang Xu ,  Bao-Ping Zhao

    IPC分类号： C07D417/14 ,  C07D211/32 ,  C07D415/00 ,  C07D419/00 ,  A61K31/4439 ,  A61K31/427 ,  A61K31/495 ,  A61K31/44 ,  A61K31/535 ,  A61K31/501 ,  A61K31/445 ,  A61K31/00

    CPC分类号： C07D417/06 ,  C07D417/14

    摘要： The present invention relates to compounds of Formula (I), methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.

    NF-kappa B Inhibitor
    6.
    发明申请
    NF-kappa B Inhibitor 审中-公开
    NF-κB抑制剂

    公开(公告)号：US20090326008A1

    公开(公告)日：2009-12-31

    申请号：US12309417

    申请日：2007-07-18

    申请人： Hironobu Ishiyama ,  Kazuhide Ohta

    发明人： Hironobu Ishiyama ,  Kazuhide Ohta

    IPC分类号： A61K31/4709 ,  A61P35/04 ,  C07D415/00

    CPC分类号： A61K31/4709

    摘要： The present invention provides an NF-κB inhibitor. The NF-κB inhibitor of the present invention contains a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R4 and R5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R1 is a hydrogen atom, etc; R2 is a hydrogen atom, etc; and R3 is a hydrogen atom, etc.

    摘要翻译： 本发明提供了NF-κB抑制剂。 本发明的NF-κB抑制剂含有由通式（1）表示的喹诺酮化合物或其盐，其中A为直接键，低级亚烷基或低级亚烷基; X是氧原子或硫原子; R4和R5各自表示氢原子; 喹诺酮骨架的3和4位之间的键是单键或双键; R1是氢原子等; R2是氢原子等; 和R3是氢原子等

    OXIMYL HCV SERINE PROTEASE INHIBITORS
    9.
    发明申请
    OXIMYL HCV SERINE PROTEASE INHIBITORS 有权
    OXIMYL HCV丝氨酸蛋白酶抑制剂

    公开(公告)号：US20090155210A1

    公开(公告)日：2009-06-18

    申请号：US12328433

    申请日：2008-12-04

    申请人： YONGHUA GAI ,  Yat Sun Or ,  Zhe Wang

    发明人： YONGHUA GAI ,  Yat Sun Or ,  Zhe Wang

    IPC分类号： A61K38/21 ,  C07D403/12 ,  C07D413/12 ,  A61K38/43 ,  A61K31/422 ,  A61K31/4155 ,  A61K31/4375 ,  A61K31/4196 ,  A61K31/427 ,  A61K31/497 ,  C07D415/00 ,  C07D471/04

    CPC分类号： A61K38/21 ,  C07D207/12 ,  C07D401/12 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D417/12

    摘要： The present invention discloses compounds of formula I or pharmaceutically acceptable salts, esters, or prodrugs thereof: which inhibit serine protease activity, particularly the activity of hepatitis C virus (HCV) NS3-NS4A protease. Consequently, the compounds of the present invention interfere with the life cycle of the hepatitis C virus and are also useful as antiviral agents. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from HCV infection. The invention also relates to methods of treating an HCV infection in a subject by administering a pharmaceutical composition comprising the compounds of the present invention.

    摘要翻译： 本发明公开了式I化合物或其药学上可接受的盐，酯或前药：其抑制丝氨酸蛋白酶活性，特别是丙型肝炎病毒（HCV）NS3-NS4A蛋白酶的活性。 因此，本发明的化合物干扰丙型肝炎病毒的生命周期，也可用作抗病毒剂。 本发明还涉及药物组合物，其包含用于给患有HCV感染的受试者施用的上述化合物。 本发明还涉及通过施用包含本发明化合物的药物组合物来治疗受试者的HCV感染的方法。